Radon and lung carcinogenesis: Mutability of p53 codons 249 and 250 to 238Pu α-particles in human bronchial epithelial cells

Carcinogenesis

Volumn 18, Issue 1, 1997, Pages 121-125

  Hussain, S Perwez ^a   Kennedy, Christopher H ^b   Amstad, Paul ^c   Lui, H ^c   Lechner, John F ^b   Harris, Curtis C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b Lovelace Biomedical and Environmental Research Institute   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLUTONIUM 238; PROTEIN P53; RADON;

ADOLESCENT; ALPHA RADIATION; ARTICLE; BRONCHUS MUCOSA; CODON; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; LARGE CELL CARCINOMA; LUNG CARCINOGENESIS; MALE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; RADIATION DOSE; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; URANIUM MINE;

ADOLESCENT; CODON; GENES, P53; HUMANS; LUNG NEOPLASMS; MALE; MUTAGENESIS; MUTAGENICITY TESTS; NEOPLASMS, RADIATION-INDUCED; RADON;

EID: 0031418652     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.1.121     Document Type: Article

References (34)

1. Greenblatt,M.S., Bennett,W.P., Hollstein,M. and Harris,C.C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology. Cancer Res., 54, 4855-4878.
2. Hollstein,M., Sidransky,D., Vogelstein,B. and Harris,C.C. (1991) p53 mutations in human cancers. Science (Wash.), 253, 49-53.
3. Hsu,I.C., Metcalf,R.A., Sun,T., Welsh,J., Wang,N.J. and Harris,C.C. (1991) p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature (Lond.), 350, 427-429.
4. Bressac,B., Kew,M.,. Wands, J. and Ozturk,M. (1991) Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature, 350, 429-431.
5. Soini,Y. et al. (1996) An aflatoxin associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis, 17, 1007-1012.
6. Ozturk,M. et al. (1991) p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet, 338, 1356-1359.
7. Li,D., Cao,Y., He,L., Wang,N.J. and Gu,J. (1993) Aberration of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis, 14, 169-173.
8. Barsh,D.E., Rudolph,J.A., Simon,J.A., Lin,A., McKenna,G.J., Baden,H.P., Halperin,A.J. and Ponten,J. (1991) A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc. Natl Acad. Sci. USA, 88, 10124-10128.
9. Takeshima,Y., Seyama,T., Bennett,W.P., Akiyama,M., Tokuoka,S., Inai,K., Mabuchi,K., Land,C.E. and Harris,C.C. (1993) p53 mutations in lung cancers from non-smoking atomic bomb survivors. Lancet, 342, 1520-1521.
10. Vahakangas,K.H., Samet,J.M., Metcalf,R.A., Welsh,J.A., Bennett,W.P., Lane,D.P. and Harris,C.C. (1992) Mutations of p53 and ras genes in radon associated lung cancer from uranium miners. Lancet, 399, 576-580.
11. Taylor,J.A., Watson,M.A., Devereux,T.R., Michels,R.Y., Saccomanno,G. and Anderson,M. (1994) p53 mutation hotspot in radon-associated lung cancer. Lancet, 343, 86-87.
12. Bartsch,H., Hollstein,M., Mustonen,R., Schmidt,J., Spiethoff,A., Wesch,H., Wiethege,T. and Muller,K.M. (1995) Screening for putative radon-specific p53 mutation hotspot in German uranium miners. Lancet, 346, 121.
13. McDonald,J.W., Taylor,J.A., Watson,M.A., Saccomanno,G. and Devereux,T.R. (1995) p53 and K-ras in radon-associated lung adenocarcinoma. Cancer Epidemiol. Biomarkers Prevent., 4, 791-793.
14. Samet,J.M. (1989) Radon and lung cancer. J. Natl Cancer Inst., 81, 745-757.
15. Moolgavkar,S.H., Luebeck,E.G., Krewski,D. and Zielinski,J.M. (1993) Radon, cigarette smoke and lung cancer: a reanalysis of the Colorado plateau uranium miners' data. Epidemiology, 4, 204-217.
16. Sankaranarayanan,K. and Chakraborty,R. (1995) Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. Radiat. Res., 143, 121-143.
17. Zhu,L.X., Waldren,C.A., Vannais,D. and Hei,T.K. (1996) Cellular and molecular analysis of mutagenesis induced by charged particles of defined linear energy transfer. Radiat. Res., 145, 251-259.
18. Evans,H.H. (1994) The prevalence of multilocus lesions in radiation-induced mutants. Radiat. Res., 137, 131-144.
19. Aguilar,F., Hussain,S.P. and Cerutti,P. (1993) Aflatoxin B1 induces the transversion of G to T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl Acad. Sci. USA, 90, 8586-8590.
20. Hussain,S.P., Aguilar,F., Amstad,P. and Cerutti,P. (1994) Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene, 9, 2277-2281.
21. 238pu α-particles. Carcinogenesis, 17, 1671-1676.
22. Elliget,K.A. and Lechner,J.F. (1992) Normal human bronchial epithelial cell cultures. In Freshney,R.I. (ed.), Culture of Epithelial Cells. Wiley-Liss, New York, NY, pp. 181-196.
23. Venitt,S. and Biggs,P.J. (1994) Radon, mycotoxins and uranium mining. Lancet, 343, 795.
24. Jin,Y., Yie,T.A. and Carothers,M.A. (1995) Non-random deletions at the dihydrofolate reductase locus of Chinese hamster ovary cells induced by alpha-particles stimulating radon. Carcinogenesis, 16, 1981-1991.
25. Jaberaboansari,A., Dunn,W.C., Preston,R.J., Mitra,S. and Waters,L.C. (1991) Mutations induced by ionizing radiation in a plasmid replicated in human cells. II. Sequence analysis of alpha particle-induced point mutations. Radiat. Res., 127, 202-210.
26. Stegelmeier,B.L., Gillett,N.A., Rebar,A.H. and Kelly,G. (1991) The molecular progression of plutonium-239-induced rat lung Carcinogenesis Ki-ras expression and activation. Mol. Carcinogen., 4, 43-51.
27. Boring,C.C., Squires,T.S. and Tong,T. (1993) Cancer statistics. J. Clin. Cancer, 43, 7-26.
28. Kadhim,M.A., Lorimore,S.A., Hepburn,M.D., Goodhead,D.T., Buckle,V.J. and Wright,E.G. (1994) Alpha-particle-induced chromosomal instability in human bone marrow cells. Lancet, 344, 987-988.
29. Tindall,K.R., Stein,J. and Hutchinson,F. (1988) Changes in DNA base sequence induced by gamma-ray mutagenesis of lambda phage and prophage. Genetics, 118, 551-569.
30. Strauss,B.S. (1991) The 'A Rule' of mutagen specificity: a consequence of DNA polymerase bypass of non-instructional lesions? BioEssays, 13, 79-84.
31. Loeb,L.A. and Preston,B.D. (1986) Mutagenesis by apurinic/apyrimidinic sites. Annu. Rev. Genet., 20, 201-230.
32. Amstad,P., Hussain,S.P. and Cerutti,P. (1994) Ultraviolet B light induced mutagenesis of p53 codons 248 and 249 in human skin fibroblasts. Mol. Carcinogen., 10, 181-188.
33. Moraes,E.C., Keyse,S.M., Pidoux,M. and Tyrrell,R. (1990) Mutagenesis by hydrogen peroxide treatment of mammalian cells: a molecular analysis. Carcinogenesis, 11, 282-293.
34. Hollstein,H., Shomer,B., Greenblatt,M., Soussi,T., Hovig,E., Montesano,R. and Harris,C.C. (1996) Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucl. Acids Res., 24, 141-146.