Effects of hirudin (thrombin specific inhibitor) in zebrafish embryos: A developmental role for thrombin

Blood Cells, Molecules and Diseases

Volumn 23, Issue 3, 1997, Pages 410-414

  Jagadeeswaran, Pudur ^a   Liu, Yuan C ^a   Eddy, Carlton A ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Development; Hemostasis; Hirudin; Thrombin; Zebrafish

Indexed keywords

HIRUDIN; THROMBIN;

ARTICLE; BLOOD CLOTTING; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ZEBRA FISH;

DANIO RERIO;

EID: 0031417675     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.1997.0158     Document Type: Article

References (13)

1. Jackson C M, Nemerson Y. Blood coagulation. Ann Rev Biochem. 49:1980;765-811.
2. Chen L B, Buchanan J M. Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci USA. 72:1975;131-133.
3. Cavanaugh K P, Gurwitz D, Cunningham D D, Bradshaw R A. Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J Neurochem. 54:1990;1735-1743.
4. Connolly A J, Ishihara H, Kahn M L, Farese R V Jr, Coughlin S R. Role of the thrombin receptor in development and evidence for a second receptor. Nature. 381:1996;516-519.
5. McNamara C A, Sarembock I J, Bachhuber B G. Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis. Semin Thromb Hemost. 22:1996;139-144.
6. Monrad D. Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. Trends Neurosci. 11:1988;541-544.
7. Jamison C S, Degen S JF. Prenatal and postnatal expression of mRNA coding for rat prothrombin. Biochim Biophys Acta. 1088:1991;208-216.
8. Weinstein J R, Gold S J, Cunningham D D, Gail C M. Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J Neurosci. 15:1995;2906-2919.
9. Jagadeeswaran P, Liu Y C. Developmental expression of thrombin in zebrafish embryos: A novel model to study hemostasis. Blood Cells Mol Dis. 23:1997;147-156.
10. Jagadeeswaran P, Liu Y C. A hemophilia model in zebrafish: Analysis of hemostasis. Blood Cells Mol Dis. 23:1997;52-57.
11. Kimmel C B, Ballard S R, Kimmel S R, Ullmann B, Schilling T F. Stages of embryonic development of the zebrafish. Dev Dyn. 20:1995;253-310.
12. Wallis R B. Hirudins: from leeches to man. Semin Thromb Hemost. 22:1996;185-196.
13. Pauli R M, Hall J G. Warfarin embryopathy. Lancet. 2:1979;144.