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of outstanding interest. The authors investigated the orientation tuning of LGN input to cortical neurons. Input layer cells in cat V1 were recorded intracellularly, and orientation tuning of the intracellular potential was measured at 38°C and 5-10°C. Cortical cooling was used to suppress intracortical inputs, by blocking nerve impulse generation in the cortex. The authors found that the tuning of the potential in the cooled cortex was the same as in the warm one, and they concluded that LGN inputs are the source of orientation tuning.
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Ferster D, Sooyoung C, Wheat H. Orientation selectivity of thalamic input to simple cells of cat visual cortex. of outstanding interest Nature. 380:1996;249-252 The authors investigated the orientation tuning of LGN input to cortical neurons. Input layer cells in cat V1 were recorded intracellularly, and orientation tuning of the intracellular potential was measured at 38°C and 5-10°C. Cortical cooling was used to suppress intracortical inputs, by blocking nerve impulse generation in the cortex. The authors found that the tuning of the potential in the cooled cortex was the same as in the warm one, and they concluded that LGN inputs are the source of orientation tuning.
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of outstanding interest. This is the first study of the contribution of intracortical inhibition to the orientation selectivity of neurons in monkey V1, using the GABA blocker bicuculline, which was administered iontophoretically in different layers of the cortex. Orientation tuning in layers 2, 3, and 4B was markedly broadened by bicuculline. Neurons in the input layers 4 Cα and 4Cβ were broadly tuned for orientation and showed little change in orientation tuning with bicuculline. The sharp orientation tuning of layer 6 neurons was unaffected by bicuculline. The implication is that intracortical inhibition plays a significant role in orientation tuning in some, but not all, layers of macaque V1.
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Sato H, Katsuyama N, Tamura H, Hata Y, Tsumoto T. Mechanisms underlying orientation selectivity in the primary visual cortex of the macaque. of outstanding interest J Physiol. 494:1996;757-771 This is the first study of the contribution of intracortical inhibition to the orientation selectivity of neurons in monkey V1, using the GABA blocker bicuculline, which was administered iontophoretically in different layers of the cortex. Orientation tuning in layers 2, 3, and 4B was markedly broadened by bicuculline. Neurons in the input layers 4 Cα and 4Cβ were broadly tuned for orientation and showed little change in orientation tuning with bicuculline. The sharp orientation tuning of layer 6 neurons was unaffected by bicuculline. The implication is that intracortical inhibition plays a significant role in orientation tuning in some, but not all, layers of macaque V1.
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GABA-induced inactivation of functionally characterized sites in cat striate cortex: Effects on orientation tuning and direction selectivity
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of outstanding interest. This is a study of intracortical interactions in cat V1. Small sites in the cortex were reversibly inactivated by iontophoresis of GABA. The effect of orientation tuning was measured from neurons located 350-700 microns away from the site of inactivation. Orientation tuning was broadened significantly when the POs of the inactivation site and the recording site differed by more than 45°. The broadening was caused by enhancing the response away from the PO of the recording site. No change in orientation tuning was found when the POs of the inactivation site and the recording site were similar.
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Crook JM, Kisvarday ZF, Eysel UT. GABA-induced inactivation of functionally characterized sites in cat striate cortex: effects on orientation tuning and direction selectivity. of outstanding interest Vis Neurosci. 14:1997;141-158 This is a study of intracortical interactions in cat V1. Small sites in the cortex were reversibly inactivated by iontophoresis of GABA. The effect of orientation tuning was measured from neurons located 350-700 microns away from the site of inactivation. Orientation tuning was broadened significantly when the POs of the inactivation site and the recording site differed by more than 45°. The broadening was caused by enhancing the response away from the PO of the recording site. No change in orientation tuning was found when the POs of the inactivation site and the recording site were similar.
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Crook, J.M.1
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of special interest. A study of the connectivity and synaptic physiology and intracortical and afferent inputs to cells in slices of cat V1 using minimal stimulation and pain-recording techniques intracellularly. The authors identified three kinds of synapses onto spiny stellate cells (the iput cells of V1): one from the LGN, with a large and highly reliable EPSP; another from layer 6 pyramidal cells onto layer 4, with smaller and less reliable PSPs; and a third type from other layer 4 spiny cells, with intermediate PSP sizes and reliability. The relative sizes and numbers of PSPs recorded in V1 led to the conclusion that the intracortical inputs provide most of the excitation to the simple cells in layer 4.
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Strafford KJ, Tarczy-Hornoch K, Martin KAC, Bannister NJ, Jack JJB. Excitatory synaptic inputs to spiny stellate cells in cat visual cortex. of special interest Nature. 382:1996;258-261 A study of the connectivity and synaptic physiology and intracortical and afferent inputs to cells in slices of cat V1 using minimal stimulation and pain-recording techniques intracellularly. The authors identified three kinds of synapses onto spiny stellate cells (the iput cells of V1): one from the LGN, with a large and highly reliable EPSP; another from layer 6 pyramidal cells onto layer 4, with smaller and less reliable PSPs; and a third type from other layer 4 spiny cells, with intermediate PSP sizes and reliability. The relative sizes and numbers of PSPs recorded in V1 led to the conclusion that the intracortical inputs provide most of the excitation to the simple cells in layer 4.
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Strafford, K.J.1
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of outstanding interest. Extracellular responses of monkey VI neurons were studied as they evolved over time. The authors measured the responses of cells in different cortical layers to a stream of images with different orientations. Using the reverse correlation technique, they obtained tuning curves of the time-delayed response to change in stimulus orientations. Layer 4C cells were broadly tuned and had simple dynamics. Upper (2, 3 and 4B) and lower (5 and 6) layer cells had more elaborate dynamics associated with sharpening of orientation tuning and a shift in the response maxima.
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Ringach DL, Hawken MJ, Shapley R. The dynamics of orientation tuning in macaque V1. of outstanding interest Nature. 387:1997;281-284 Extracellular responses of monkey VI neurons were studied as they evolved over time. The authors measured the responses of cells in different cortical layers to a stream of images with different orientations. Using the reverse correlation technique, they obtained tuning curves of the time-delayed response to change in stimulus orientations. Layer 4C cells were broadly tuned and had simple dynamics. Upper (2, 3 and 4B) and lower (5 and 6) layer cells had more elaborate dynamics associated with sharpening of orientation tuning and a shift in the response maxima.
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of special interest. Simulation study of a network model of a hypercolumn in primary visual cortex, using the same gross architecture as in [13, 14] but a more realistic conductance-based Hodgkin - Huxley type model of a single neuron dynamics. Analysis of the results shows that the main predictions of the simplified model [13] regarding the statics and dynamics of orientation tuning also apply to this realistic model. The authors also showed that in the conductance-based dynamics, strong feedback interactions can give rise to temporally irregular firing patterns, suggesting that local recurrent intracortical dynamics may contribute to the stochasticity of neuronal responses in the cortex.
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J Physiol
, vol.440
, pp. 735-769
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Douglas, R.J.1
Martin, K.A.C.2
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