Unmasking large and persistent reductions in proliferation rate of aging cells

In Vitro Cellular and Developmental Biology - Animal

Volumn 33, Issue 10, 1997, Pages 809-818

  Chow, Ming ^a   Kong, Monica ^a   Rubin, Harry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Genetic damage; Growth factors; Senescence; Transformation

Indexed keywords

DNA; GROWTH FACTOR;

ANIMAL CELL; ARTICLE; CELL AGING; CELL CULTURE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; GROWTH RATE; MOUSE; NONHUMAN; SENESCENCE;

ANIMALIA; BOVINAE;

EID: 0031417219     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-997-0161-8     Document Type: Article

References (31)

1. Brown, D. G.; Sun, X.-M.; Cohen, G. M. Dexamethasone-induced apop-losis involves cleavage to large fragments prior to internucleosomal fragmentation. J. Biol. Chem. 268:3037-3039; 1993.
2. Cameron, I. L. Cell proliferation and renewal in aging mice. J. Gerontol. 27:162-172; 1972.
3. Chow, M.; Rubin, H. Evidence for cellular aging in long term confluent cultures: heritable impairment of proliferation, accumulation of age pigments and their loss in neoplastic transformation. Mech. Ageing Dev. 89:165-184; 1996.
4. Chow, M.; Rubin, H. Irreversibility of cellular aging and neoplastic transformation: a clonal analysis. Proc. Natl. Acad. Sci. USA 93:9793-9798; 1996.
5. Clive, J. M.; Spencer, R. P. Analysis of mortality from carcinoma of the prostate. Mech. Ageing Dev. 83:31-41; 1995.
6. Cristofalo, V. J.; Pignolo, R. J. Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev. 73:617-638; 1993.
7. Dix, D.; Cohen, P. On the role of aging in cancer incidence. J. Theor. Biol. 83:163-173; 1980.
8. Frisch, S. M.; Francis, H. Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124:619-626; 1994.
9. Giulotto, E.; Knights, C.; Stark, G. R. Hamster cells with increased rates of DNA amplification, a new phenotype. Cell 48:837-845; 1987.
10. Grove, G. L.; Kligman, A. M. Age associated changes in human epidermal cell renewal. J. Gerontol. 38:137-142; 1983.
11. Hill, A. B.; Schimke, R. T. Increased amplification in L5178Y mouse lymphoma cells with hydroxyurea-incluced chromosomal aberrations. Cancer Res. 45:5050-5057; 1985.
12. Jainchill, J. L.; Todaro, G. J. Stimulation of cell growth in vitro by serum with and without growth factor. Exp. Cell Res. 59:137-146; 1970.
13. Johnston, R. N.; Feeler, J.; Hill, A. B., et al. Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cell. Mol. & Cell Biol. 6:3373-3381; 1986.
14. Lesher, S.; Fry, R. J. M.; Kohn, H. I. Age and the generation time of the mouse duodenal epithelial cell. Exp. Cell Res. 24:334-343; 1961.
15. Pendergrass, W. R.; Li, Y.; Jiang, D., et al. Caloric restriction: conservation of cellular replicative capacity in vitro accompanies life-span extension in mice. Exp. Cell Res. 217:309-316; 1995.
16. Riggs, J. E. Longitudinal Gompertzian analysis of lung cancer mortality in the U.S., 1968-1986; rising lung cancer mortality is the natural consequence of competitive deterministic mortality dynamics. Mech. Ageing Dev. 59:79-93; 1991.
17. Riggs, J. E. Longitudinal Gompertzian analysis of prostate cancer mortality in the U.S., 1962-1987: a method of demonstrating relative environmental, genetic and competitive influences upon mortality. Mech. Ageing Dev. 60:243-253; 1991.
18. Rubin, H.; Chow, M.; Yao, A. Cellular aging, destabilization and cancer. Proc. Natl. Acad. Sci. USA 93:1825-1830; 1996.
19. Rubin, H.; Yao. A.; Chow, M. Heritable, population-wide damage to cells as'the driving force of neoplastic transformation. Proc. Natl. Acad. Sci. USA 92:4843-4847; 1995.
20. Rubin, H.; Yao, A.; Chow, M. Neoplastic development: paradoxical relation between impaired cell growth at low population density and excessive growth at high density. Proc. Natl. Acad. Sci. USA 92:7734-7738; 1995.
21. Schimke, R. T. Gene amplification: what are we learning? Mutat. Res. 276:145-149; 1992.
22. Schneider, E. L.; Mitsui, Y. The relationship between in vitro cellular aging and in vivo human age. Proc. Natl. Acad. Sci. USA 73:3584-3588; 1976.
23. Shipley, G. D.; Ham, R. G. Improved medium and culture conditions for clonal growth with minimum serum protein and for enhanced serum-free survival of Swiss 3T3 cells. In Vitro 17:656-670; 1981.
24. Shock, N. Aging of regulatory mechanisms. In: Cape, R. D. T.; Coe, R. M.; Rossman, I., eds. Fundamentals of geriatric medicine. New York: Raven Press; 1983:51-62.
25. Smith, V.; Chou, K. H.; Lashkari, D., et al. Functional analysis of yeast chromosome V by genetic footprinting. Science; 274:2069-2074: 1996.
26. Smith, J. R.; Pereira-Smith, O.; Schneider, E. L. Colony size distributions as a measure of in vivo and in vitro aging. Proc. Natl. Acad. Sci. USA 75:1353-1356; 1978.
27. Summerhayes, L. C.; Franks, L. M. Effects of donor age on neoplastic transformation of adult mouse bladder epithelium in vitro. J. Natl. Cancer Inst. 62:1017-1032; 1979.
28. Thrasher, J. D. Age and the cell cycle of the mouse colonie epithelium. Anal. Rec. 157:621-626; 1967.
29. Thrasher, J. D. Age and the cell cycle of mouse esophageal epithelium. Exp. Gerontol. 6:19-24; 1971.
30. Williams, G. T.; Smith, C. A.; Spooner, E., et al. Hemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76-79; 1990.
31. Wolf, N. S.; Penn, P. E.; Jiang, D., et al. Caloric restriction: conservation of in vivo cellular replicative capacity accompanies life-span extension in mice. Exp. Cell Res. 217:317-323; 1995.