Amelioration of mitochondrial function by a novel antioxidant U-101033E following traumatic brain injury in rats

Journal of Neurotrauma

Volumn 14, Issue 12, 1997, Pages 907-917

  Xiong, Y ^a   Peterson, P L ^a   Muizelaar, J P ^a   Lee, C P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Brain mitochondria; Calcium; Oxidative phosphorylation; Rats; Traumatic brain injury

Indexed keywords

ANTIOXIDANT; CALCIUM; CITRIC ACID; DRUG VEHICLE; PYRROLOPYRIMIDINE DERIVATIVE; U 101033 E; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY WEIGHT; BRAIN INJURY; BRAIN MITOCHONDRION; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; ELECTRON TRANSPORT; FOREBRAIN; HEMISPHERE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; MEMBRANE PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT;

EID: 0031416299     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1997.14.907     Document Type: Article

References (46)

1. CLIFTON, G.L., KREUTZER, J.S., CHOI, S.C. et al. (1993). Relationship between Glasgow Outcome Scale and neuropsychological measures after brain injury. Neurosurg. 33, 34-39.
2. DIXON, C.E., CLIFTON, G.L., LIGHTHALL, J.W., YAGHMAI, A.A., and HAYES, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Meth. 39, 252-262.
3. DOPPENBERG, E.M.R., and BULLOCK, R. (1997). Clinical neuro-protection trials in severe traumatic brain injury: Lessons from previous studies. J. Neurotrauma 14, 71-80.
4. ERNSTER, L. (1993). Lipid peroxidation in biological membranes: Mechanisms and implications, in: Active Oxygens, Lipid Peroxides and Antioxidants. K. Yagi (ed), CRC Press: Boca Raton, FL, pp. 1-30.
5. FORSMARK-ANDRE, P., LEE, C.P., DALLNER, G., and ERNSTER, L. (1997). Reduction of ubiquinone prevents its destruction accompanying lipid peroxidation in submitochondrial particles and the concomitant inactivation of the respiratory chain. Free Rad. Biol. Med. 22, 391-400.
6. GENNARELLI, T.A. (1993). Mechanisms of brain injury. J. Emerg. Med. 11, 5-11.
7. 2+ indicator with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
8. GRUMME, T., BAETHMANN, A., KOLODZIEJCZYK, D. et al. (1995). Treatment of patients with severe head injury by triamcinolone: A prospective, controlled multicenter clinical trial of 396 cases. Res. Exp. Med. (Berl.) 195, 217-229.
9. HALL, E.D. (1993). The role of oxygen radicals in traumatic injury: Clinical implications. J. Emerg. Med. 11 (Suppl), 31-36.
10. HALL, E.D. (1995). Inhibition of lipid peroxidation in central nervous system trauma and ischemia. J. Neurosci. 134 (Suppl). 79-83.
11. HALL, E.D., ANDRUS, P.K., SMITH, S.L. et al. (1996a). Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. Acta Neurochir (Suppl) 66, 107-113.
12. HALL, E.D., ANDRUS, P.K., and YONKERS, P.A. (1993). Brain hydroxyl radical generation in acute experimental head injury. J. Neurotrauma 10, 588-594.
13. HALL, E.D., and BRAUGHLER, J.M. (1993). Free radicals in CNS injury, in: Molecular and Cellular Approaches to the Treatment of Brain Diseases. S.G. Waxman (ed), Raven Press: New York, pp. 81-105.
14. HALL, E.D., McCALL, J.M., YONKERS, P.A., CHASE, R.L., and BRAUGHLER, J.M. (1987). A non-glucocorticoid steroid analog of methylprednisolone duplicates its high dose pharmacology in models of CNS trauma and neuronal membrane damage. J. Pharmacol. Exp. Therap. 242, 137-142.
15. HALL, E.D., SMITH, S.L., and OOSTVEEN, J.A. (1996b). Inhibition of lipid peroxidation attenuates axotomy-induced apoptotic degeneration of facial motor neurons in neonatal rats. J. Neurosci. Res. 44, 293-299.
16. HARDERS, A., KAKARIEKA, A., and BRAAKMAN, R. (1996). Traumatic subarachnoid hemorrhage and its treatment with nimodipine, German. tsah study group. J. Neurosurg. 85, 82-89.
17. HOVDA, D.A., YOSHINO, A., KAWAMATA, T., KATAYAMA, Y., and BECKER, D.P. (1991). Diffuse prolonged depression of cerebral oxidative metabolism following concussive brain injury in the rat: A cytochrome oxidase histochemistry study. Brain Res. 567, 1-10.
18. 45Ca accumulation. Acta Neurochir (suppl) 60, 521-523.
19. KATAYAMA, Y., BECKER, D.P., TAMURA, T., and HOVDA, D.A. (1990). Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. Neurosurg. 73, 889-900.
20. KATAYAMA, Y., MAEDA, T., KOSHINAGA, M., KAWAMATA, T., and TSUBOKAWA, T. (1995). Role of excitatory amino acid-mediated ionic fluxes in traumatic brain injury. Brain Path. 5, 427-435.
21. KONTOS, H.A., and POVLISHOCK, J.T. (1986). Oxygen radicals in brain injury. CNS Trauma 3, 257-263.
22. LEE, C.P., SCIAMANNA, M., and PETERSON, P.L. (1993). Intact rat brain mitochondria from a single animal: Preparation and properties. Meth. Toxicol. 2, 41-49.
23. LINN, F., PASCHEN, W., OPHOFF, B.G., and HOSSMANN, K.A. (1987). Mitochondrial respiration during recirculation after prolonged ischemia in cat brain. Exp. Neurol. 96, 321-333.
24. LIGHTHALL, J.W. (1988). Controlled cortical impact: A new experimental brain injury model. J. Neurotrauma 5, 1-15.
25. LOWRY, O.H., ROSEBOUGH, N.J., FARR, A.L., and RANDALL, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
26. MARION, D.W., and WHITE, M.J. (1996). Treatment of experimental brain injury with moderate hypothermia and 21-aminosteroids. J. Neurotrauma 13, 139-147.
27. MARION, D.W., OBRIST, W.D., CARLIER, P.M.M., PENROD, L.E., and DARBY, J.M. (1993). The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report. J. Neurosurg. 79, 354-362.
28. McINTOSH, T.K., and SMITH, D.H. (1995). Therapeutic strategies in current clinical trials. J. Head Trauma Rehabil. 10, 1-6.
29. McINTOSH, T.K., SMITH, D.H., MEANEY, D.F., KOTAPKA, M.J., GENNARELLI, T.A., and GRAHAM, D.I. (1996). Neuropathological sequelae of traumatic brain injury: Relationship to neurochemical and biomechanical mechanisms. Lab. Invest. 74, 315-342.
30. MUIZELAAR, J.P., MARMAROU, A., YOUNG, H.F. et al. (1993). Improving the outcome of severe head injury with the oxygen radical scavenger. Polyethylene glycol conjugated superoxide dismutase: A phase II trial. J. Neurosurg. 78, 375-382.
31. NEUZIL, J., THOMAS, S.R., and STOCKER, R. (1997). Requirement for promotion, or inhibition by alpha-tocopherol of radical-induced inhibition initiation of plasma lipoprotein lipid peroxidation. Free Rad. Biol. Med. 22, 57-71.
32. PETERSON, P.L., XIONG, Y., MUIZELAAR, J.P., and LEE, C.P. (1997). Protective effect of U-101033E on rat brain mitochondrial function following traumatic brain injury. Abstract book of the 65th Annual Meeting of Am. Assoc. of Neurol. Surgeons, p. 260, Abstr. 813.
33. SCIAMANNA, M.A., ZINKEL, J., FABI, A.Y., and LEE, C.P. (1992). Ischemic injury to rat forebrain mitochondria and cellular calcium homeostasis. Biochim. Biophys. Acta 1134, 223-232.
34. SCIAMANNA, M.A., and LEE, C.P. (1993). Ischemia/reperfusion-induced injury of forebrain mitochondria and prevention by ascorbate. Arch. Biochem. Biophys. 305, 215-224.
35. SMITH, S.L., ANDRUS, P.K., ZHANG, J.-R., and HALL, E.D. (1994). Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J. Neurotrauma 11, 393-104.
36. SMITH, S.L., OOSTTVEEN, J.A., and HALL, E.D. (1996). Two novel pyrrolopyrimidine lipid peroxidation inhibitors U-101033E and U-104067F protect facial motor neurons following neonatal axotomy. Exp. Neurol. 141, 304-309.
37. SOSIN, D.M., SACKS, J.J., and SMITH, S.M. (1989). Head injury-associated deaths in the United States from 1979 to 1986. JAMA 262, 2251-2255.
38. VERWEIJ, B.H., MUIZELAAR, J.P., VINAS, F.C., PETERSON, P.L., XIONG, Y., and LEE, C.P. (1997). Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111) Neurol. Res. 19, 334-339.
39. 31P magnetic resonance spectroscopy study. J. Cereb. Blood Flow Metab. 7, 563-571.
40. WALLIS, R.A., PANIZZON, K.L., and GIRARD, J.M. (1996). Traumatic neuroprotection with inhibitors of nitric oxide and ADP-ribosylation. Brain Res. 710, 169-177.
41. WITTING, P.K., BOWRY, V.W., and STOCKER, R. (1995). Inverse deuterium kinetic isotope effect for peroxidation in human low-density lipoprotein (LDL): A simple test for tocopherol-mediated peroxidation of LDL lipids. FEBS Lett. 375, 45-49.
42. XIONG, Y., PETERSON, P.L., MUIZELAAR, J.P., and LEE, C.P. (1997a). Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury. J. Neurotrauma 14, 23-34.
43. XIONG, Y., PETERSON, P.L., MUIZELAAR, J.P., and LEE, C.P. (1997b). Attenuation of mitochondrial dysfunction by a novel blood-brain barrier permeable antioxidant (U-101033E) following traumatic brain injury. FASEB J. 11, A955.
44. YANG, M.S., DeWITT, D.S., BECKER, D.P., and HAYES, R.L. (1985). Regional brain metabolite levels following mild experimental head injury in the cat. J. Neurosurg. 63, 617-621.
45. YOUNG, B., RUNGE, J.W., WAXMAN, K.S. et al. (1996). Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial. JAMA 276, 538-543.
46. ZHANG, Y., MARCILLAT, O., GIRLIVI, C., ERNSTER, L., and DAVIES, K.J. (1990). The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J. Biol. Chem. 265, 16330-16336.