Effects of varying marijuana potency on deposition of tar and Δ9-THC in the lung during smoking

Pharmacology Biochemistry and Behavior

Volumn 58, Issue 4, 1997, Pages 1145-1150

  Matthias, Peter ^a   Tashkin, Donald P ^a   Marques Magallanes, Jose A ^a   Wilkins, Jeffrey N ^a,b   Simmons, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

9 tetrahydrocannabinol (THC); 'High'; Carboxyhemoglobin boost; Lung; Marijuana; Smoking topography; Tar deposition; Tar yield

Indexed keywords

CANNABIS; CARBOXYHEMOGLOBIN; DRONABINOL; TAR;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG DISPOSITION; DRUG TISSUE LEVEL; HUMAN; HUMAN EXPERIMENT; INHALATIONAL DRUG ADMINISTRATION; LUNG PARENCHYMA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATORY SYSTEM; SMOKING; STRENGTH; TOPOGRAPHY;

ADULT; BIOLOGICAL AVAILABILITY; CANNABIS; CARBOXYHEMOGLOBIN; HALLUCINOGENS; HUMANS; LUNG; MALE; MARIJUANA SMOKING; TARS; TETRAHYDROCANNABINOL;

EID: 0031416283     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(97)00328-6     Document Type: Article

References (16)

1. Aronow W. S., Goldsmith J. R., Kern J. C., Johnson L. L. Effects of smoking cigarettes on cardiovascular hemodynamics. Arch. Environ. Health. 28:1974;330-332.
2. Dixon W. J. BMDP Statistical software manual. 1992;University of California Press, Berkeley, CA.
3. 9-tetrahydrocannabinol in urine II. A HPLC procedure. J. Anal. Toxicol. 7:1983;262-264.
4. Gieringer D. Waterpipe study. Bulletin of the Multidisciplinary Association of Psychodelic Studies (MAPS). 6:1996;59-63.
5. Hinds W., First M. W., Huber G. L., Shea J. W. A method for measuring respiratory deposition of cigarette smoke during smoking. Am. Ind. Hyg. Assoc. J. 44:1983;113-118.
6. Hoffmann D., Brunnemann K. D., Gori G. B., Wynder E. L. On the carcinogenicity of marijuana smoke. Recent Adv. Phytochem. 9:1975;63-81.
7. Hollander M., Wolfe D. A. Nonparametric statistical methods. 1973;Wiley, New York.
8. Longo L. D. Carbon monoxide. Effects on oxygenation of the fetus in utero Science. 194:1976;523-525.
9. Morrison D. F. Multivariate statistical methods. 3:1990;McGraw-Hill, New York. 145-150.
10. Rose J. E., Wu T.-C., Djahed B., Tashkin D. P. Noninvasive measurement of smoker's tar and nicotine intake. Behav. Res. Methods Instrum. Comput. 19:1987;295-299.
11. SAS SAS/STAT user's guide, Ver. 1993;SAS Institute Inc, 6, 4th ed. Cary, NC.
12. Tashkin D. P., Fligiel S., Wu T.-C., Gong H. Jr., Barbers R. G., Coulson A. H., Simmons M. S., Beals T. F. Effects of habitual use of marijuana and/or cocaine on the lung. Research findings on smoking of abused substances, NIDA Research Monograph #99, DHHS Publication No(ADM). 1990;63-87 Alcohol, Drug Abuse, and Mental Health Administration, U.S. Government Printing Office, 90-1690. Washington, DC.
13. 9-THC. Pharmacol. Biochem. Behav. 40:1991;651-656.
14. 9-THC delivery from the first and second halves of a marijuana cigarette. Pharmacol. Biochem. Behav. 40:1991;657-661.
15. USDHHS Smoking and Health. A report of the Surgeon General, vol. 14; 1979;U.S. Government Printing Office, DHEW Publication No (PHS) 79-50066. Washington, DC. 19-72.
16. Wu T.-C, Tashkin D. P., Djahed B., Rose J. E. Pulmonary hazards of smoking marijuana as compared with tobacco. N. Engl. J. Med. 318:1988;347-351.