Epitope Mapping of Twelve Monoclonal Antibodies Against the Phenolic Glycolipid-1 of M. leprae

International Journal of Leprosy and Other Mycobacterial Diseases

Volumn 65, Issue 4, 1997, Pages 477-486

  Fujiwara, Tsuyoshi ^a   Minagawa, Fumishige ^b   Sakamoto, Yoshiki ^b   Douglas, James T ^c  

^a NARA UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; PHENOLIC GLYCOLIPID I;

ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; DRUG RECEPTOR BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; HUMAN; TARGET CELL;

ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIGENS, BACTERIAL; BINDING SITES, ANTIBODY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; GLYCOLIPIDS; KINETICS; MYCOBACTERIUM LEPRAE;

EID: 0031415504     PISSN: 0148916X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. CHATTERJEE, D., CHO, S.-N., STEWART, C., DOUGLAS, J. T., FUJIWARA, T. and BRENNAN, P. J. Synthesis and immunoactivity of neoglyco-proteins containing the trisaccharide unit of phenolic glycolipid-I of Mycobacterium leprae. Carbohydr. Res. 183 (1988) 241-260.
2. CHO, S.-N., HUNTER, S. W., GELBER, R. H., REA, T. H. and BRENNAN, P. J. Quantitation of phenloic glycolipid of M. leprae and relevance to glycolipid antigenemia in leprosy. J. Infect. Dis. 150 (1986) 560-569.
3. FUJIWARA, T., HUNTER, S. W., CHO, S.-N., AsPINALL, G. O. and BRENNAN, P. J. Chemical synthesis and serology of disaccharides and trisaccharides of phenolic glycolipid antigens from leprosy bacillus and preparation of a disaccharide-protein conjugate for serodiagnosis of leprosy. Infect. Immun. 43 (1984) 245-252.
4. FUJIWARA, T. and IZUMI, S. Synthesis of the neoglycoconjugates of phenolic glycolipid-related trisaccharides for the serodiagnosis of leprosy. Argric. Biol. Chem. 51 (1987) 2539-2547.
5. GIGG, J., GIGG, R., PAYNE, S. and CONANT, R. Synthesis of propyl 4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-2,3-di-O-methyl-α-L- rhamnopyranoside. Charbohydr. Res. 141 (1985) 91-97.
6. GOTO, M., MINAUCHI, Y., NOBUHARA, Y. and SATO, E. Immuno-histochemical demonstration of Mycobacterium leprae in the nervous system of long-term cured leprosy patients using a M. leprae-specific anti-PGL antibody. Jpn. J. Trop. Med. Hyg. 21 (1993) 117-121.
7. HUNTER, S. W., FUJIWARA, T. and BRENNAN, P. J. Structure and antigenicity of major specific glycolipid antigen of Mycobacterium leprae. J. Biol. Chem. 257 (1983) 15072-15078.
8. LEMIEUX, R. U., BUNDLE, D. R. and BAKER, D. A. The properties of a "synthetic" antigen related to the human blood-group Lewis a. J. Am. Chem. Soc. 97 (1975) 4076-4083.
9. LUK, J. M. C., LIND, S. M., TSANG, R. S. W. and LINDBERG, A. A. Epitope mapping of four monoclonal antibodies recognizing the hexose core domain of Salmonella lipopolysaccharide. J. Biol. Chem. 266 (1991) 23215-23225.
10. MAHON, A. C., KURLIGN, A., KEBEDE, B., BECX-BLEUMINK, M. and LEFFORD, M. J. Urinary phenolic glycolipid I in the diagnosis and management of leprosy. J. Infect. Dis. 163 (1991) 653-656.
11. MEHRA, V., BRENNAN, P. J., RADA, E., CONVIT, J. and BLOOM, B. R. Lymphocyte suppression in Leprosy induced by unique M. leprae glycolipid. Nature 308 (1984) 194-196.
12. MINAGAWA, F. Serodiagnosis of leprosy. In: Latent Infection of Bacteria and Host Response, Vol. 2. Kurata, T, and Amano, F., eds. Toyko: Saikon Publishing Co., 1996, pp. 45-55.
13. PATIL, S. A., GIRDHAR, B. K., SINGH, K. P. and SENGUPTA, U. Detection of Mycobacterium leprae antigens in sera of leprosy patients by sandwich immunoradiometric assay using monoclonal antibodies. J. Clin. Microbiol. 28 (1990) 2792-2796.
14. TAI, T., PAULSON, J. C., CAHAN, L. D. and IRIE, F. Ganglioside GM2 as a human tumor antigen (OFA-1-1). Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 5392-5396.
15. VACHULA, M., HOLZER, T. J. and ANDERSEN, B. R. Suppression of monocyte oxidative response by phenolic glycolipid I of Mycobacterium leprae. J. Immunol. 142 (1989) 1696-1701.