Simultaneous expression of germline γ1 and ε immunoglobulin heavy chain transcripts in single murine splenic B-cells

Molecular Immunology

Volumn 34, Issue 12-13, 1997, Pages 919-927

  Goodman, David J ^a,b   Gerondakis, Steve ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

Germline transcription; Interleukin 4; Isotype switching

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; INTERLEUKIN 4; LIPOPOLYSACCHARIDE; PROTEOGLYCAN; SYNDECAN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTER; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; IMMUNOGLOBULIN GENE; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPLEEN CELL;

ANIMALIA; EUKARYOTA; MURINAE;

EID: 0031415172     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(97)00106-5     Document Type: Article

References (31)

1. Alt F. W., Blackwell K., DePinho R. A., Reth M. and Yancopoulos G. D. (1986) Regulation of genome rearrangement events during lymphocyte differentiation. Immun. Rev. 89, 5-47.
2. Berton M. T. and Vitetta E. S. (1992) IL-4 induced expression of germline γ1 transcripts in B cells following cognate interactions with T helper cells. Int. Immun. 3, 387-391.
3. Berton M. T., Uhr J. W. and Vitetta E. S. (1989) Synthesis of germline γ1 immunoglobulin heavy chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon γ. Proc. natn. Acad. Sci. U.S.A. 88, 2829-2831.
4. Bottaro A., Lansford R., Xu L., Zhang J., Rothman P. and Alt F. (1994) I region transcription (per se) promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process. EM BO J. 13, 665-674.
5. Cebra J. J., Komisar J. L. and Sweitzer P. A. (1984) CH isotype switching during normal B-lymphocyte development. Annu. Rev. Immun. 2, 493-522.
6. Daniels G. A. and Lieber M. R. (1995) RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination. Nucleic Acids Res. 23, 5006-5011.
7. Esser C. and Radbruch A. (1989) Rapid induction of transcription of unrearranged S γ1 switch regions in activated murine B cells by interleukin 4. EM BO J. 8, 483-489.
8. Finkelman F., Urban J., Beckman M., Schooley K., Holmes J. and Katonka I. (1991) Regulation of murine in vivo IgG and IgE responses by monoclonal anti-IL-4 receptor antibody. Int. Immun. 3, 599-604.
9. α genes: implications for commitment to an isotype switch. Int. Immun. 4, 1145-1150.
10. Gerondakis S. (1990) Structure and expression of murine germline immunoglobulin epsilon heavy chain transcripts induced by interleukin 4. Proc. natn. Acad. Sci. U.S.A. 87, 245-254.
11. Goodman D. J., Gaff C. and Gerondakis S. (1993) The IL-4 induced increase in the frequency of resting murine splenic B cells expressing germline Ig heavy chain γ1 transcripts correlates with subsequent switching to IgG1. Int. Immun 5, 199-208.
12. Harriman G., Bradley A., Das S., Rogers-Fani P. and Davis A. (1996) IgA class switching in la exon deficient mice. Role of germline transcription in class switch recombination. J. clin. Invest. 97, 477-485.
13. Iwatso T., Shimizu A., Honjo T. and Yamagishi H. (1990) Circular DNA is excised by immunoglobulin class switch recombination. Cell 62, 143-149.
14. Kishimoto T. and Hirano T. (1988) Molecular regulation of B lymphocyte responses. Annu. Rev. Immun. 6, 485-496.
15. Kuhn R., Rajewsky K. and Muller W. (1991) Generation and analysis of interleukin-4 deficient mice. Science 254, 707-709.
16. + B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immun. 22, 3001-3011.
17. Lefkovits I. and Waldmann H. (1984) Limiting dilution analysis of the cells of immune system. 1. The clonal basis of the immune response. Immun. Today 5, 265-269.
18. Lorenz M., Jung S. and Radbruch A. (1995) Switch transcripts in immunoglobulin class switching. Science 267, 1825-1828.
19. Lorenz M., Jung S. and Radbruch A. (1995) How cytokines control immunoglobulin class switching. Behring Institute Mitteilungen 96, 97-102.
20. Lutzker S., Rothman P., Pollock R., Coffman R. and Alt F. W. (1988) Mitogen and IL-4 regulated expression of germline Ig γ2b transcripts: evidence for directed heavy chain class switching. Cell 53, 177-183.
21. Matsuoka M., Yoshida K., Maeda T., Usuda S. and Sakano H. (1990) Switch circular DNA is formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell 62, 135-142.
22. McHeyzer-Williams M. (1989) Combinations of interleukins 2, 4 and 5 regulate the secretion of murine immunoglobulin isotypes. Eur. J. Immun. 19, 2025-2029.
23. Ogimoto M., Mizuna K., Tate G., Takahash H., Kattagiri M., Hasegawa K. and Yukura H. (1992) Regulation of lipopolysaccharide and IL-4 induced immunoglobulin heavy chain gene activation: differential roles for CD45 and Lyb-2. Int. Immun. 6, 651-660.
24. Ohara J. and Paul W. E. (1985) B cell stimulatory factor BSF-1: production of a monoclonal antibody and its characterisation. Nature 315, 333-339.
25. Oritani K. and Kincade P. W. (1996) Identification of stromal cell products that interact with pre-B cells. J. Cell Biol. 134, 771-782.
26. Ott D. and Alt F., Marcu K. (1987) Immunoglobulin heavy chain switch region recombination with a retroviral vector in murine pre-B cells. EM BO J. 6, 577-663.
27. Reaban M. and Griffin J. (1990) Induction of RNA-stabilized DNA conformers by transcription of an immunoglobulin switch region. Nature 348, 342-344.
28. Shinkai Y., Nakauchi H., Honjo T. and Okumura K. (1988) Mouse immunoglobulin allotypes: multiple differences between the nucleic acid sequences of the IgEa and IgEb alleles. Immunogenetics 27, 288-292.
29. Siebenkotten G., Esser C., Wabl M. and Radbruch A. (1996) The murine IgG1/IgE class switch program. Eur. J. Immun. 22, 1827-1834.
30. Thurner M., Clausen H., Sharon N., Berger E. G. (1993) Use of O-glycosylation-defective human lymphoid cell lines and flow cytometry to delineate the specificity of Moluccella laevis lectin and monoclonal antibody 5F4 for the Tn antigen (Gal-NAc alpha 1-O-Ser/Thr). Immun. Lett. 36, 239-243.
31. Von-Schwedler U. and Jack M., Wabl M. (1990) Circular DNA is a product of immunoglobulin class switch rearrangement. Nature 345, 452-456.