메뉴 건너뛰기




Volumn 30, Issue 6, 1997, Pages 739-743

Effects of Pimobendan and its active metabolite, UD-CG 212 Cl, on Ca2+-activated K+ channels in vascular smooth-muscle cells

Author keywords

Ca2+ (i); Ca2+ sensitivity; K(Ca) channel; Pimobendan; UD CG 212 Cl

Indexed keywords

N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; O NORPIMOBENDAN; PIMOBENDAN; POTASSIUM CHANNEL;

EID: 0031414832     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199712000-00007     Document Type: Article
Times cited : (5)

References (31)
  • 1
    • 84912671626 scopus 로고
    • Cardiovascular profile of UD-CG 115, a new orally and long acting cardiotonic compound, not related to β-mimetics or cardiac glycosides
    • Diederen W, Dammgen J, Kadatz R. Cardiovascular profile of UD-CG 115, a new orally and long acting cardiotonic compound, not related to β-mimetics or cardiac glycosides. Naunyn Schmiedebergs Arch Pharmacol 1982;321:141-6.
    • (1982) Naunyn Schmiedebergs Arch Pharmacol , vol.321 , pp. 141-146
    • Diederen, W.1    Dammgen, J.2    Kadatz, R.3
  • 2
    • 0024428451 scopus 로고
    • Hemodynamic profile of the cardiotonic agent pimobendan
    • van Meel JC, Diederen W. Hemodynamic profile of the cardiotonic agent pimobendan. J Cardiovasc Pharmacol 1989;14(suppl II):S1-6.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.2 SUPPL.
    • Van Meel, J.C.1    Diederen, W.2
  • 3
  • 4
    • 0023944395 scopus 로고
    • Pimobendan (UD-CG 115 BS) in the treatment of severe congestive heart failure: An acute haemodynamic crossover and double-blind study with two different doses
    • Walter M, Liebens I, Goethals H, Renard M, Dresse A, Bernard R. Pimobendan (UD-CG 115 BS) in the treatment of severe congestive heart failure: an acute haemodynamic crossover and double-blind study with two different doses. Br J Clin Pharmacol 1988; 25:323-9.
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 323-329
    • Walter, M.1    Liebens, I.2    Goethals, H.3    Renard, M.4    Dresse, A.5    Bernard, R.6
  • 5
    • 0024466152 scopus 로고
    • Clinical efficacy of pimobendan (UD-CG 115 BS) in patients with chronic congestive heart failure
    • Baumann G, Ningel K, Permanetter B. Clinical efficacy of pimobendan (UD-CG 115 BS) in patients with chronic congestive heart failure. J Cardiovasc Pharmacol 1989;14(suppl II):S23-30.
    • (1989) J Cardiovasc Pharmacol , vol.14 , Issue.2 SUPPL.
    • Baumann, G.1    Ningel, K.2    Permanetter, B.3
  • 6
    • 0021345075 scopus 로고
    • UD-CG 115-A cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle
    • Honerjager P, Heiss A, Schafer-Korting M, Schonsteiner G, Reiter M. UD-CG 115-A cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle. Naunyn Schmiedebergs Arch Pharmacol 1984;325:259-69.
    • (1984) Naunyn Schmiedebergs Arch Pharmacol , vol.325 , pp. 259-269
    • Honerjager, P.1    Heiss, A.2    Schafer-Korting, M.3    Schonsteiner, G.4    Reiter, M.5
  • 7
    • 0022648976 scopus 로고
    • Phosphodiesterase inhibiting properties of newer inotropic agents
    • Scholz H, Meyer W. Phosphodiesterase inhibiting properties of newer inotropic agents. Circulation 1986;73(suppl III):99-108.
    • (1986) Circulation , vol.73 , Issue.3 SUPPL. , pp. 99-108
    • Scholz, H.1    Meyer, W.2
  • 8
    • 0021687326 scopus 로고
    • Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative 4,5-dihydro-6-[2-(methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)- phyidazolinone
    • Ruegg J, Pfitzer G, Eubler D, Zeugner C. Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative 4,5-dihydro-6-[2-(methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)- phyidazolinone. Arzneimittelforschung 1984;34:1736-8.
    • (1984) Arzneimittelforschung , vol.34 , pp. 1736-1738
    • Ruegg, J.1    Pfitzer, G.2    Eubler, D.3    Zeugner, C.4
  • 9
    • 0028072772 scopus 로고
    • Effects of pimobendan, its active metabolite UD-CG 212 Cl, and milrinone on isolated blood vessels
    • Fujimoto S. Effects of pimobendan, its active metabolite UD-CG 212 Cl, and milrinone on isolated blood vessels. Eur J Pharmacol 1994;265:159-66.
    • (1994) Eur J Pharmacol , vol.265 , pp. 159-166
    • Fujimoto, S.1
  • 10
    • 0026515374 scopus 로고
    • Electrophysiological actions of the pimobendan metabolite, UG-CD 212 Cl, in guinea pig myocardium
    • Westfall MV, Wahler GM, Fujino K, Solaro RJ. Electrophysiological actions of the pimobendan metabolite, UG-CD 212 Cl, in guinea pig myocardium. J Pharmacol Exp Ther 1991;260:58-63.
    • (1991) J Pharmacol Exp Ther , vol.260 , pp. 58-63
    • Westfall, M.V.1    Wahler, G.M.2    Fujino, K.3    Solaro, R.J.4
  • 11
    • 0028965128 scopus 로고
    • + channel of vascular smooth muscle cells
    • + channel of vascular smooth muscle cells. Life Sci 1995;56:291-8.
    • (1995) Life Sci , vol.56 , pp. 291-298
    • Miyoshi, H.1    Nakaya, Y.2
  • 12
    • 0024208155 scopus 로고
    • Pharmacokinetic profile of OPC-8212 in humans: A new, nonglycosidic, inotropic agent
    • Ohnishi A, Ishizaki T. Pharmacokinetic profile of OPC-8212 in humans: a new, nonglycosidic, inotropic agent. J Clin Pharmacol 1988;28:719-26.
    • (1988) J Clin Pharmacol , vol.28 , pp. 719-726
    • Ohnishi, A.1    Ishizaki, T.2
  • 13
    • 0025298548 scopus 로고
    • Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone
    • Cell Physiol 28
    • Nelson MT, Patlak JB, Worley JF, Atanded NB. Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone. Am J Physiol 1990;259(Cell Physiol 28):C3-18.
    • (1990) Am J Physiol , vol.259
    • Nelson, M.T.1    Patlak, J.B.2    Worley, J.F.3    Atanded, N.B.4
  • 14
    • 0025914660 scopus 로고
    • Calcium-activated potassium channels from coronary smooth muscle reconstituted in lipid bilayers
    • Heart Circ Physiol
    • Toro L, Vaca L, Stefani E. Calcium-activated potassium channels from coronary smooth muscle reconstituted in lipid bilayers. Am J Physiol 1991;260 (Heart Circ Physiol):H1779-89.
    • (1991) Am J Physiol , vol.260
    • Toro, L.1    Vaca, L.2    Stefani, E.3
  • 15
    • 0023677647 scopus 로고
    • Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas
    • Heart Circ Physiol
    • Sadoshima J, Akaike N, Kanaide H, Nakamura M. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol 1988;255 (Heart Circ Physiol):H754-9.
    • (1988) Am J Physiol , vol.255
    • Sadoshima, J.1    Akaike, N.2    Kanaide, H.3    Nakamura, M.4
  • 17
    • 0015097243 scopus 로고
    • The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers
    • Ross R. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 1971;50:172-86.
    • (1971) J Cell Biol , vol.50 , pp. 172-186
    • Ross, R.1
  • 18
    • 0025254352 scopus 로고
    • Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats
    • Fujimoto S, Matsuda T. Effects of pimobendan, a cardiotonic and vasodilating agent with phosphodiesterase inhibiting properties, on isolated arteries and veins of rats. J Pharmacol Exp Ther 1990;252:1304-11.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 1304-1311
    • Fujimoto, S.1    Matsuda, T.2
  • 19
    • 0019441262 scopus 로고
    • Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
    • Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FG. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391: 85-100.
    • (1981) Pflugers Arch , vol.391 , pp. 85-100
    • Hamill, O.P.1    Marty, A.2    Neher, E.3    Sakmann, B.4    Sigworth, F.G.5
  • 21
    • 0025248571 scopus 로고
    • Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
    • Chijiwa T, Mishima A, Hagiwara M, et al. Inhibition of forskolin-induced neunte outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 1990;265:5267-72.
    • (1990) J Biol Chem , vol.265 , pp. 5267-5272
    • Chijiwa, T.1    Mishima, A.2    Hagiwara, M.3
  • 22
    • 0028076281 scopus 로고
    • Use of the cyclic AMP antagonist, Rp-cAMPS, to distinguish between cyclic AMP-dependent and cyclic AMP-independent contractile responses in rat ventricular cardiomyocytes
    • Bell D, McDermott BJ. Use of the cyclic AMP antagonist, Rp-cAMPS, to distinguish between cyclic AMP-dependent and cyclic AMP-independent contractile responses in rat ventricular cardiomyocytes. J Mol Cell Cardiol 1994;26:1439-48.
    • (1994) J Mol Cell Cardiol , vol.26 , pp. 1439-1448
    • Bell, D.1    McDermott, B.J.2
  • 23
    • 0022628578 scopus 로고
    • New positive inotropic agents in the treatment of congestive heart failure: Mechanisms of action and recent clinical developments
    • Colucci WS, Wright RF, Braunwald E. New positive inotropic agents in the treatment of congestive heart failure: mechanisms of action and recent clinical developments. N Engl J Med 1986;314:349-58.
    • (1986) N Engl J Med , vol.314 , pp. 349-358
    • Colucci, W.S.1    Wright, R.F.2    Braunwald, E.3
  • 24
    • 0025978355 scopus 로고
    • Different mechanisms involved in the positive inotropic effects of benzimidazole derivative UD-CG 115 BS (pimobendan) and its demethylated metabolite UD-CG 212 Cl in canine ventricular myocardium
    • Endoh M, Shibasaki T, Satoh H, Norota I, Ishihata A. Different mechanisms involved in the positive inotropic effects of benzimidazole derivative UD-CG 115 BS (pimobendan) and its demethylated metabolite UD-CG 212 Cl in canine ventricular myocardium. J Cardiovasc Pharmacol 1991;17:365-75.
    • (1991) J Cardiovasc Pharmacol , vol.17 , pp. 365-375
    • Endoh, M.1    Shibasaki, T.2    Satoh, H.3    Norota, I.4    Ishihata, A.5
  • 25
    • 0025982134 scopus 로고
    • Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium
    • Bohm M, Morano I, Pieske B, et al. Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium. Circ Res 1991;68:689-701.
    • (1991) Circ Res , vol.68 , pp. 689-701
    • Bohm, M.1    Morano, I.2    Pieske, B.3
  • 26
    • 0023797004 scopus 로고
    • The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments
    • Fujino K, Sperelakis N, Solaro RJ. The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. Circ Res 1988;63:911-22.
    • (1988) Circ Res , vol.63 , pp. 911-922
    • Fujino, K.1    Sperelakis, N.2    Solaro, R.J.3
  • 27
    • 0022540094 scopus 로고
    • Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties
    • Verdouw PD, Hartog JM, Duncker DJ, Roth W, Saxena PR. Cardiovascular profile of pimobendan, a benzimidazole-pyridazinone derivative with vasodilating and inotropic properties. Eur J Pharmacol 1986;126:21-30.
    • (1986) Eur J Pharmacol , vol.126 , pp. 21-30
    • Verdouw, P.D.1    Hartog, J.M.2    Duncker, D.J.3    Roth, W.4    Saxena, P.R.5
  • 28
    • 0027483273 scopus 로고
    • Calcium sensitization with pimobendan: Pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure
    • Hagemeijer F. Calcium sensitization with pimobendan: pharmacology, haemodynamic improvement, and sudden death in patients with chronic congestive heart failure. Eur Heart J 1993;14:551-66.
    • (1993) Eur Heart J , vol.14 , pp. 551-566
    • Hagemeijer, F.1
  • 30
    • 0029108913 scopus 로고
    • Physiological roles and properties of potassium channels in arterial smooth muscle
    • Cell Physiol 37
    • Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995;268(Cell Physiol 37):C799-822.
    • (1995) Am J Physiol , vol.268
    • Nelson, M.T.1    Quayle, J.M.2
  • 31
    • 0024817158 scopus 로고
    • Outward potassium current in freshly isolated smooth muscle cell of dog coronary arteries
    • Wilde DW, Lee KS. Outward potassium current in freshly isolated smooth muscle cell of dog coronary arteries. Circ Res 1989; 65: 1718-34.
    • (1989) Circ Res , vol.65 , pp. 1718-1734
    • Wilde, D.W.1    Lee, K.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.