Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 273, Issue 6 42-6, 1997, Pages

  Benloucif, Susan ^a   Masana, Monica I ^a   Dubocovich, Margarita L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

2 125I iodomelatonin binding; Mel(1a) mRNA; Old; Suprachiasmatic nucleus

Indexed keywords

IODINE 125; MELATONIN; MELATONIN RECEPTOR; MESSENGER RNA;

AGING; ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; HORMONE RECEPTOR INTERACTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS REGULATION; RECEPTOR DENSITY; SUPRACHIASMATIC NUCLEUS;

EID: 0031413904     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.273.6.r1855     Document Type: Article

References (13)

1. Benloucif, S., and M. L. Dubocovich. Phase response curves to light and to melatonin in the C3H/HeN mouse. J. Biol. Rhythms 11: 114-126, 1996.
2. Benloucif, S., M. I. Masana, and M. L. Dubocovich. Light-induced phase shifts of circadian activity rhythms and immediate early gene expression in the suprachiasmatic nucleus are attenuated in old C3H/HeN mice. Brain Res. 747: 34-42, 1997.
3. Brock, M. A. Chronobiology and aging. J. Am. Geriatr. Soc. 39: 74-91, 1991.
4. Campbell, S. S., M. Terman, A. J. Lewy, D. J. Dijk, C. I. Eastman, and Z. Boulos. Light treatment for sleep disorders: consensus report. V. Age-related disturbances. J. Biol. Rhythms 10: 151-154, 1995.
5. Dawson, D., and N. Encel. Melatonin and sleep in humans. J. Pineal Res. 15: 1-12, 1993.
6. Dollins, A. B., I. V. Zhdanova, R. J. Wurtman, H. J. Lynch, and M. H. Deng. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc. Natl. Acad. Sci. USA 91: 1824-1828, 1994.
7. Dubocovich, M. L., S. Benloucif, and M. I. Masana. Melatonin receptors in the mammalian suprachiasmatic nucleus. Behav. Brain Res. 73: 141-147, 1996.
8. Haimov, I., P. Lavie, M. Laudon, P. Herer, C. Vigder, and N. Zisapel. Melatonin replacement therapy of elderly insomniacs. Sleep 18: 598-603, 1995.
9. Hastings, M. H., F. J. P. Ebling, J. Grosse, J. Herbert, E. S. Maywood, J. D. Mikkelsen, and A. Sumova. Immediate-early genes and the neuronal bases of photic and non-photic entrainment. In: Circadian Clocks and Their Adjustment, edited by D. J. Chadwick and K. Ackrill. West Sussex, UK: Wiley, 1995, p. 175-197.
10. Laitinen, J. T., M. Viswanathan, O. Vakkuri, and J. M. Saavedra. Differential regulation of the rat melatonin receptors: selective age-associated decline and lack of melatonin-induced changes. Endocrinology 130: 2139-2144, 1992.
11. Lewy, A. J., S. Ahmed, J. M. Latham-Jackson, and R. L. Sack. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol. Int. 9: 380-392, 1992.
12. Masana, M. I., S. Benloucif, and M. L. Dubocovich. Circadian variations in melatonin receptor density in the suprachiasmatic nucleus (SCN) of C3H/HeN mice. Soc. Neurosci. Abstr. 21: 184, 1995.
13. Masana, M. I., S. Benloucif, and M. L. Dubocovich. Light-induced c-fos mRNA expression in the suprachiasmatic nucleus and the retina of C3H/HeN mice. Mol. Brain Res. 42: 193-201, 1996.