Evaluation of the hepatocyte-specific contrast agent gadobenate dimeglumine for MR imaging of acute hepatitis in a rat model

Journal of Magnetic Resonance Imaging

Volumn 7, Issue 1, 1997, Pages 147-152

  Marzola, Pasquina ^a   Maggioni, Fabio ^a   Vicinanza, Eleonora ^a   Daprà, Massimo ^a   Cavagna, Friedrich M ^a  

^a Bracco SpA   (Italy)

Author keywords

Contrast enhancement; Gadobenate dimeglumine; Gadolinium; Hepatitis; Liver, MR

Indexed keywords

GADOBENATE DIMEGLUMINE;

ACUTE HEPATITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; LIVER DISEASE; LIVER FUNCTION; LIVER PARENCHYMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACUTE DISEASE; ANIMALS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; HEPATITIS, ANIMAL; IMAGE ENHANCEMENT; INFUSIONS, INTRAVENOUS; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0031413009     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.1880070121     Document Type: Article

References (19)

1. Kaplan MM. Laboratory tests. In: Schiff L, Schiff ER, eds. Diseases of the liver, 6th ed. Philadelphia: JB Lippincott, 1987; 219-260.
2. Elizondo G, Weissleder R, Stark DD, et al. Hepatic cirrhosis and hepatitis: MR imaging enhanced with superparamagnetic iron oxide. Radiology 1990; 174:797-801.
3. Reimer P, Weissleder R, Lee AS, Buettner S, Wittenberg J, Brady TJ. Asialoglycoprotein receptor function in benign liver disease: evaluation with MR imaging. Radiology 1991; 178:769-774.
4. Tanimoto A, Stark DD. Magnetic resonance for liver imaging: cell-specific contrast agents fail to detect hepatitis. Invest Radiol 1991; 26:S139-S141.
5. Tanimoto A, Kreft BP, Baba Y, et al. Evaluation of hepatocyte-specific paramagnetic contrast media for MR imaging of hepatitis. JMRI 1993; 3:786-793.
6. Rosati G, Pirovano G, Spinazzi A. Interim results of phase II clinical testing of gadobenate dimeglumine. Invest Radiol 1994; 29:5183-5185.
7. de Haën C, Lorusso V, Luzzani F, Tirone P. Hepatic transport of the magnetic resonance imaging contrast agent gadobenate dimeglumine in the rat. Acad Radiol 1995; 2:232-238.
8. de Haën C, Gozzini L. Soluble-type hepatobiliary contrast agents for MR imaging. JMRI 1993; 3:179-186.
9. Lorusso V, Poggesi I, Cavagna F, de Haën C, Tirone P. Gd-BOPTA/Dimeg: relationship between pharmacokinetics and MRI liver signal enhancement (abstract). Eur Radiol 1991; 1: 5218.
10. - rats of the MRI contrast agent gadobenate dimeglumine. Acad Radiol 1996; 3(Suppl. 1): (in press).
11. Cavagna FM, Maggioni F, Vicinanza E, de Haën C. Detection of hepatitis in rats with Gd-BOPTA/Dimeg (abstract). In: Book of Abstracts: Society of Magnetic Resonance in Medicine 1992. Berlin, Germany: Society of Magnetic Resonance in Medicine, 1992; 563.
12. Weissleder R, Ruda H. MacMRI: an interactive software program for image analysis, 1989 (personal communication).
13. Cavagna F, Tirone P, Felder E, de Haën C. Hepatobiliary contrast agents for MRI. In: Ferrucci JT, Stark DD, eds. Liver imaging: current trends and new techniques. Boston: Andover Medical, 1990; 384-393.
14. Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical recipes in C. In: Numerical Recipes. New York: Cambridge University Press, 1991; 542.
15. Mathur-de-Vre R, Grimee R, Parmentier F, Binet J. The use of agar gel as a basic reference material for calibrating relaxation times and imaging parameters. Magn Reson Med 1985; 2:176-179.
16. Young IR. Special pulse sequences and techniques. In: Stark DD, Bradley WG, eds. Magnetic resonance imaging. St. Louis: CV Mosby Company, 1988; 84-107.
17. Coley BD, Mattrey RF, Baker KG, Peterson T, Burgan AR. MR imaging assessment of experimental hepatic dysfunction with Mn-DPDP. JMRI 1995; 5:11-16.
18. Cavagna FM, Lorusso V, Maggioni F, Visentin G, de Haën C. Mechanism of liver MRI signal enhancement by Gd-BOPTA/ Dimeg (abstract). In: Book of Abstracts: Society for Magnetic Resonance Imaging 1993. San Francisco: 527.
19. Kreft BP, Tanimoto A, Stark DD, et al. Enhancement of tumor-liver contrast-to-noise ratio with gadobenate dimeglumine in MR imaging of rats. JMRI 1993; 3:41-19.