Uridine preserves ATP during hypoxic perfusion of the rat heart

Asia Pacific Heart Journal

Volumn 6, Issue 3, 1997, Pages 190-196

  Lin, Z ^a   Richards, S M ^a   Rosenfeldt, F L ^a   Pepe, S ^a  

^a ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; LACTIC ACID; OROTIC ACID; URIDINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIME;

EID: 0031410734     PISSN: 13280163     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1328-0163(97)90029-4     Document Type: Article

References (30)

1. M.A.J. Newman X.-Z. Chen M. Rabinov J.F. Williams F.L. Rosenfeldt Sensitivity of the recently infarcted heart to cardioplegic arrest J Thorac Cardiovasc Surg 97 1989 593 604
2. C. Munsch J.F. Williams F.L. Rosenfeldt Impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: the protective effect of orotic acid J Molec Cell Cardiol 21 1989 751 754
3. C.M. Munsch F.L. Rosenfeldt K. O'Halloran L.H. Langley R.A.J. Conyers J.F. Williams The effect of orotic acid on the response of the recently infarcted rat heart to hypothermic cardioplegia Eur J Cardio-Thorac Surg 5 1991 82 93
4. S.M. Richards R.A.J. Conyers J.L. Fisher F.L. Rosenfeldt Cardioprotection by orotic acid: metabolism and mechanism of action J Molec Cell Cardiol 1997 (in press)
5. D.K. Reibel M.I. Rovetto Myocardial ATP synthesis and mechanical function following oxygen deficiency Am J Physiol 234 1978 H620 H624
6. W. Bernauer Post-ischemic release of nucleosides and oxypurines in isolated rat hearts. Possible involvement of ventricular fibrillation Basic Res Cardiol 86 1991 1 10
7. G. Kolos J.F. Williams J.B. Hickie Biochemical studies in myocardial hypertrophy and metabolic support of the acutely stressed myocardium Adv Cardiol 12 1974 106 115
8. L.E. Bailey Orotic acid prevents changes in cardiac sarcolemmal glycoproteins & contractility associated with muscular dystrophy in hamsters Experentia 36 1980 6 7
9. J.A. Donahoe F.L. Rosenfeldt C.M. Munsch J.F. Williams The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart Int J Biochem 25 1993 163 182
10. T. Yeh Jr I.M. Rebeyka E.R. Jakoi D.E. Johnson R.J. Dignan C.M. Dyke A.S. Weschler Orotic acid improves left ventricular recovery four days after heterotopic transplantation Ann Thorac Surg 58 1994 409 415
11. T. Gasser J.D. Moyer R.E. Handschumacher Novel single-pass exchange of circulating uridine in rat liver Science 213 1981 777 778
12. W.R. Pels Rijcken G.J.M. Hooghwinkel W. Ferwerda Pyrimidine metabolism and sugar nucleotide synthesis in rat liver Biochem J 266 1990 777 783
13. J. Kypson G. Hait Effects of uridine and inosine on glucose metabolism in skeletal muscle and activated lipolysis in adipose tissue J Pharmacol Exp Therapeutics 199 1976 565 574
14. J. Kypson G. Hait R. Matthew Effects of uridine on the performance and the metabolism of oxygenated and hypoxic rabbit hearts J Molec Cell Cardiol 10 1978 545 565
15. J. Aussedat Effect of uridine supply on glycogen resynthesis after ischaemia in the isolated perfused rat heart Cardiovasc Res 17 1983 145 151
16. J. Aussedat A. Ray A. Rossi Uridine incorporation in normal and ischemic perfused rat heart Molec Physiol 6 1984 247 256
17. S.M. Richards K. Dora S. Rattigan E.Q. Colquhoun M.G. Clark The vasodilatory action and metabolism of UTP in the perfused rat hind limb Am J Physiol 264 1993 H233 H237
18. 32P-Phosphate autoradiography as an indicator of regional oxygen consumption J Molec Cell Cardiol 25 1993 289 302
19. J. Wynants B. Petrov J. Nijof H. van Belle Optimization of a HPLC method for the determination of nucleosides and their catabolites J Chromatography 386 1987 297 308
20. H.U. Bergmeyer Methods of Enzymatic Analysis 2nd Edition 1974 Academic Press New York
21. B.M. Wice L.J. Reitzer D. Kennell The continuous growth of vertebrate cells in the absence of sugar J Biol Chem 256 1981 7812 7819
22. B.M. Wice D. Kennell Ribose-l-P is the precursor for nucleic acid synthesis in animal cells growing in uridine in the absence of sugar J Biol Chem 257 1982 2578 2583
23. V.T. Wiedmeier R. Rubio R.M. Berne 1972 Inosine incorporation into myocardial nucleotides J Molec Cell Cardiol 4 1972 445 452
24. J.W. deJong C. Kalkman Myocardial adenosine kinase: Activity and localization determined with rapid, radiometric assay Biochim Biophys Acta 320 1973 388 396
25. R. Rubio R.M. Berne Localization of purine and pyrimidine nucleoside phosphorylases in heart, kidney and liver Am J Physiol 239 1980 H721 H730
26. H.-G. Zimmer C. Trendellengurg H. Kammermeier E. Gerlach De novo synthesis of myocardial adenine nucleotides in the rat: Acceleration during recovery from oxygen deficiency Circ Res 32 1973 635 642
27. H.-G. Zimmer H. Ibel Ribose accelerates the repletion of the ATP pool during recovery from reversible ischemia of the rat myocardium J Molec Cell Cardiol 16 1984 863 866
28. I. von Kugelgen E. Schoffel K. Starke Inhibition by nucleotides acting at presynaptic P2-receptors of sympathetic neuro-effector transmission in the mouse isolated vas deferens Naunyn Schmiedebergs Arch Pharmacol 340 1989 522 532
29. I. Findlay Interactive regulation of the ATP-sensitive potassium channel of cardiac muscle J Cardiovasc Pharmacol 24 Suppl 4 1994 S6 S11
30. 2+-mobilizing receptors for ATP and UTP Cell Calcium 17 1995 111 119