How does surfactant really work?

Journal of Paediatrics and Child Health

Volumn 33, Issue 6, 1997, Pages 471-475

  Hills, B A ^a  

^a MATER CHILDREN S HOSPITAL   (Australia)

Author keywords

Alveolar models; Lung fluid balance; Respiratory distress syndrome; Surfactant

Indexed keywords

APOLIPOPROTEIN; LUNG SURFACTANT; PHOSPHOLIPID; SURFACTANT; TYLOXAPOL;

ADSORPTION; DRUG FORMULATION; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; OUTCOMES RESEARCH; PRIORITY JOURNAL; RELAPSE; RESPIRATORY DISTRESS; REVIEW;

EID: 0031409721     PISSN: 10344810     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1754.1997.tb01651.x     Document Type: Review

References (37)

1. Corbet A. Clinical trials of synthetic surfactant in the respiratory distress syndrome of premature infants. Clin. Perinatol. 1993; 20: 737-60.
2. Shapiro DL, Notter RF. Controversies regarding surfactant therapy. Clin. Perinatol. 1988; 15: 891-02.
3. Milner AD. How does exogenous surfactant work? Arch. Dis. Childhood 1993; 68: 253-4.
4. Clements JA. Surface phenomena in relation to pulmonary function. Physiologist 1962; 5: 11-28.
5. Hawgood S, Clements JA. Pulmonary surfactant and its proteins. J. Clin. Invest. 1990; 86: 1-6.
6. Gil J, Bachofen H, Gehr P, Weibel ER. Alveolar volume-surface area relation in air- and saline-filled lungs fixed by vascular perfusion. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 1979; 47: 990-1001.
7. Weibel ER, Limacher W, Bachofen H. Electron microscopy of rapidly frozen lungs: Evaluation on the basis of standard criteria. J. Appl. Physiol. 1982; 53: 516-27.
8. Hills BA. Role of surfactant in the alveolus. J. Appl. Physiol. 1985; 59: 660-2.
9. von Neergaard K. Neue Auffasungen über einen Grundbegriff der Atemmechanik die Retraktionskraft der Lunge, abhängig von der Oberflächenspannung in den Alveolen. Z. Ges. Exp. Med. 1929; 66: 373-94.
10. Hills BA. The Biology of Surfactant. Cambridge University Press, Cambridge. 1988.
11. Nieman GF, Bredenberg CE, Clark WR, West NR. Alveolar function following surfactant deactivation. J. Appl. Physiol. 1981; 51: 895-954.
12. Guyton AC, Moffatt DS, Adair TH. Role of alveolar surface tension in transepthalial movement of fluid. In Robertson B, van Golde LMG, Batenburg JJ, eds. Pulmonary Surfactant. Elsevier, Amsterdam, 1984; 171-86.
13. Barrow RE, Hills BA. A critical assessment of the Wilhelmy method in studying lung surfactants. J. Physiol. 1979; 295: 217-27.
14. Bangham AD. Lung surfactant: how it does and does not work. Lung 1987; 165: 17-25.
15. Adamson AW. Physical Chemistry of Surfaces. 2nd edn. Wiley, New York. 1967; 352-67.
16. Hills BA, Cotton DB. Release and lubricating properties of amniotic surfactants and the very hydrophobic surfaces of the amnion, chorion and their interface. Obstet. Gynecol. 1986; 68: 550-4.
17. Holly FJ. Tear film formation and rupture. In Holly FJ, Lamberts DW, MacKeen DL, eds. The Preocular Tear Film. Dry Eye Institute, Lubbock, Texas, 1986; 634-45.
18. Ueda S, Ishii N, Matsumoto S, Hayashi K, Okayasu M. Ultrastructural studies on surface lining layer (SLL) of the lungs. Part II. J. Jap. Med. Soc. Biol. Interface 1983; 14: 30-5.
19. Ueda S, Kawamura K, Ishii N et al. Ultrastructural studies on surface lining layer of the lungs: Part IV. Resected human lungs. J. Jap. Med. Soc. Biol. Interface 1985; 16: 34-60.
20. Weibel ER. Lung cell biology. In Fishman AP, Fisher AB, eds. Handbook of Physiology, The Respiratory System Section 3, Vol. III. Amercian Physiological Society, Washington. 1985; 47-91.
21. Guyton, AC. A concept of negative interstitial pressure based on pressures in implanted perforated capsules. Circ. Res. 1963; 12: 399-414.
22. What is the true role of surfactant in the lung? Thorax 1981; 36: 1-4.
23. Gil J. Alveolar surface, intra-alveolar fluid pools and respiratory volume changes. J. Appl. Physiol. 1983; 64: 321-4.
24. Dermer GB. The fixation of pulmonary surfactant for electron microscopy. I. The alveolar surface lining layer. J. Ultrastructure Res. 1969; 27: 88-104.
25. Kisch B. Electron microscopy of the lungs in acute pulmonary edema. Exp. Med. Surg. 1958; 16: 17-8.
26. Perkins WR, Dause RB, Parente RA et al. Role of lipid polymorphisms pulmonary surfactant. Science 1996; 273: 330-32.
27. Scarpelli EM, Mautone AJ. The surfactant monolaver theory does not explain surfactant function in vivo. Pediatric Pulmonol. 1995; 19: 198-202 and 1995; 20: 324-33.
28. Scarpelli EM, Mautone AJ. The surfactant monolaver theory does not explain surfactant function in vivo. Pediatric Pulmonol. 1995; 19: 198-202 and 1995; 20: 324-33.
29. Scarpelli EM, Kumar A, Doyle C, Clutario BC. Functional anatomy and volume-pressure characteristics of Immature lungs. Respir. Physiol. 1981; 45: 25-41.
30. Davis JM, Veness-Meechan K, Notter RH, Bhutani VK, Kendig JW, Shapiro DL. Changes In pulmonary mechanics after the administration of surfactant to infants with respiratory distress syndrome. N. Engl. J. Med. 1988; 319: 476-9.
31. Hills BA. A hydrophobia oligolamellar lining to surfaces in various tissues: A possible ubiquitous barrier. Med. Sci. Res. 1992; 20: 543-50.
32. Rollins M, Jenkins J, Tubman R, Corkey C, Wilson D. Comparison of clinical responses to natural and synthetic surfactants. J. Perinat. Med. 1993; 21: 341-7.
33. Whitsett JA, Weaver TE. Structure, function and regulation of pulmonary surfactant proteins. In: Bourbon JR, ed. Pulmonary Surfactant. CRC Press, Boca Raton, Florida, 1991; 77-96.
34. Benjamins JA, Morell P. Proteins of myelin and their metabolism. Neurochem. Res. 1978; 3: 137-74.
35. Morley CJ, Bangham AD, Johnson P, Thorburn GD, Jenkins G. Physical and physiological properties of dry lung surfactant. Nature 1978; 271: 162-3.
36. Stratton CJ. Morphology of surfactant producing cells and of the alveolar lining. In Robertson B, van Golde LMG, Battenburg JJ, eds. Pulmonary Surfactant. Elsevier, Amsterdam, 1984; 68-118.
37. Morley CJ, Bangham AD, Miller N, Davis JA. Dry artificial lung surfactant and its effect on very premture babies. Lancet 1981; 64-8.