Hypothalamic-pituitary-adrenal axis function, psychopathological traits, and natural killer (NK) cell activity in Anorexia Nervosa

Psychoneuroendocrinology

Volumn 22, Issue 8, 1997, Pages 575-590

  Staurenghi, Antonio H ^a   Masera, Rosa Gabriella ^a   Prolo, Paolo ^b   Griot, Giulietta ^a   Sartori, Maria Luisa ^a   Ravizza, Luigi ^b   Angeli, Alberto ^a  

^a SAN LUIGI GONZAGA HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Anorexia Nervosa; Depression; HPA axis; Immunity; Natural Killer cells; Proopiomelanocortin

Indexed keywords

BETA ENDORPHIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; HYDROCORTISONE; PROOPIOMELANOCORTIN;

ADOLESCENT; ADULT; ANOREXIA NERVOSA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MONONUCLEAR CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PSYCHOPATHY;

ADOLESCENT; ADULT; AMENORRHEA; ANOREXIA NERVOSA; CYTOTOXICITY TESTS, IMMUNOLOGIC; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-2; KILLER CELLS, NATURAL; LEUKOCYTE COUNT; PITUITARY-ADRENAL SYSTEM; PSYCHIATRIC STATUS RATING SCALES; PSYCHOPATHOLOGY;

EID: 0031409709     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(97)00070-X     Document Type: Article

References (61)

1. Angeli, A., Masera, R. G., Staurenghi, A. H., Solomon, S., Bateman, A., Sartori, M. L., Lazzero, A. and Griot, G. (1994) The expanding field of hypothalamic - pituitary - adrenal modulation of human Natural Killer (NK) cell activity. Annals of the New York Academy of Sciences 719, 328-349.
2. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders. APA, Washington DC, USA.
3. Besedowsky, H. O., Del Rey, A. and Sorkin, E. (1985) Immunoneuroendocrine interactions. Journal of Immunology 135, 750-754.
4. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Clinical and Laboratory Investigations 21(Suppl.), 31-50.
5. Brambilla, F., Ferrari, E., Peirone, A., Draisci, A., Sacerdote, P. and Panerai, A. (1996) Immunoendocrine aspects of anorexia nervosa. Psychiatry Research 62, 97-104.
6. Carr, D. J. J., Decosta, B. R., Jacobson, A. E., Rice, K. C. and Blalock, J. E. (1990) Corticotropin-releasing hormone augments natural killer cell activity through a naloxone sensitive pathway. Journal of Neuroimmunology 28, 53-61.
7. Carrol, B. (1980) Clinical application of neuroendocrine research in depression. In Handbook of Biological Psychiatry, Part III: Brain Mechanisms and Abnormal Behavior. Genetics and Neuroendocrinology, eds. H. M. van Praag, H. M. Lader, O. J. Rafaelsen and E. J. Sachar, pp. 173-179. Marcel Dekker, New York.
8. Cason, J., Ainley, C. C., Wolstencroft, R. A., Norton, K. R. W. and Thompson, R. P. H. (1986) Cell-mediated immunity in anorexia nervosa. Clinical and Experimental Immunolology 64, 370-375.
9. Ceresa, F., Angeli, A., Strumia, E. and Dellepiane, M. (1965) Behavior of the feed-back mechanisms controlling ACTH secretion in normal subjects and under different endocrine conditions, and relative clinical implications. In: Proceedings of the 2nd International Congress of Endocrinology, Excerpta Medica International Congress Series no. 83, pp. 1027-1040. Elsevier, Amsterdam.
10. Chiappelli, F., Gwirtsman, H. E., Gormley, G., Lowy, M., Nguen, L. D., Nguyen, L., Esmail, I., Fahey, J. and Weiner, H. (1990) Neuroendocrine and immunological resistance to dexamethasone load in Anorexia Nervosa patients. Annals of the New York Academy of Sciences 594, 442-445.
11. Chiappelli, F., Gwirtsman, H. E., Lowy, M., Gormley, G., Nguyen, L. D., Nguyen, L., Popow, J., Esmail, I., Fahey, J. L. and Strober, M. (1991) Pituitary - adrenal - immune system in normal subjects and in patients with anorexia nervosa: the number of circulating helper T lymphocytes (CD4) expressing the homing receptor Leu-8 is regulated in part by pituitary - adrenal products. Psychoneuroendocrinology 16, 423-432.
12. Chiappelli, F., Gwirtsman, H. E., Gormley, G. J., Lowy, M. T., Esmail, I., Nguyen, L. D., Nguyen, L., Strober, M. and Weiner, H. (1992) Effects of dexamethasone on selective lymphocyte subpopulations in hypercortisolemic patients with anorexia nervosa and with bulimia nervosa: preliminary report. International Journal of Eating Disorders 12(Suppl. 1), 37-46.
13. Cooper, P. J., Taylor, M. J., Cooper, Z. and Fairburn, C. G. (1987) The development and validation of the Body Shape Questionnaire. International Journal of Eating Disorders 6(Suppl.4), 485-494.
14. Cunningham-Rundles, S., Filipa, D. A., Braun, D., Antonelli, P. and Ashikari, H. (1981) Natural cytotoxicity and peripheral blood lymphocytes and regional lymphonode cells in breast cancer in women. Journal of the National Cancer Institute 67, 585-590.
15. Emeric-Sauval, E., Bello, M., Guitelman, A., Finkelman, S., Nahmod, V. and Arzi, E. (1989) Anorexia nervosa and bulimia: a model for the study of immune-neuroendocrine interactions in response to human CRH. Neuroendocrinology Letters 11, 270.
16. Emeric-Sauval, E., Polack, E., Finkelman, S., Bello, M., Criscuolo, M., Nahmod, V., Guitelman, A. and Arzi, E. (1991) Interferon-gamma production - lymphocyte proliferative response in anorexia nervosa patients. Neuroendocrinology Letters 13, 204.
17. Ferrari, E., Bossolo, P.A., Marelli, G., Foppa, S., Magni, P. and Zanoletti, M.G. (1986) Chronoendocrinological aspects of anorexia nervosa. In Disorders of Eating Behavior, A Psychoneuroendocrine Approach. Advances in Biosciences, Vol. 60, eds. E. Ferrari and F. Brambilla, pp. 207-217. Pergamon Press, Oxford and New York.
18. Fischer, E.G. (1988) Opioid peptides modulate immune functions. A review. Immunopharmacology and Immunotoxicology 10(Suppl. 3), 265-326.
19. Gabrilovac, J., Zadjclovic, J., Osmak, M., Suchanec, E., Zupanovic, Z. and Boranic, M. (1988) NK cell activity and estrogen hormone levels during normal human pregnancy. Gynecology and Obstetrics Investigations 25, 165-172.
20. Garner, D.M., Olmstead, M.P. and Polivy, J. (1983) Development and validation of a multidimensional Eating Disorder Inventory for Anorexia Nervosa and Bulimia. International Journal of Eating Disorders 2(Suppl.2), 15-34.
21. Gatti, G., Cavallo, R., Sartori, M. L., Delponte, D., Masera, R., Salvadori, A., Carignola, R. and Angeli, A. (1987) Inhibition by cortisol of human natural killer (NK) cell activity. Journal of Steroid Biochemistry 26, 49-58.
22. Gatti, G., Masera, R., Carignola, R., Magro, E., Sartori, M. L., Maina, L., Staurenghi, A. and Angeli, A. (1991) Interplay between pro-opiomelanocortin-derived peptides and glucocorticoids in the functional regulation of natural killer cell activity. In Stress and Related Disorders, from Adaptation to Dysfunction, eds. A. R. Genazzani, G. Nappi, F. Petraglia and E. Martignoni, pp. 435-442. The Parthenon Publishing Group, Carnforth, UK and Park Ridge, NY, USA.
23. Gatti, G., Masera, R. G., Pallavicini, L., Sartori, M. L., Staurenghi, A., Orlandi, F. and Angeli, A. (1993) Interplay in vitro between ACTH, β-endorphin and glucocorticoids in the modulation of spontaneous and lymphokine-inducible human natural killer (NK) cell activity. Brain Behavior Immunity 7, 16-28.
24. Glantz, S.A. (1988) Primer of Biostatistics, The Program (Italian edition). McGraw Hill Libri Italia, Milano.
25. Gold, P. W., Gwirtsman, H. E., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W. H., Jimerson, D., Ebert, M., Rittmaster, R., Loriaux, D. L. and Chrousos, G. P. (1986) Abnormal Hypothalamic - pituitary - adrenal function in anorexia nervosa: pathophysiological mechanisms in underweight and weight-corrected patients. New England Journal of Medicine 314, 1335-1342.
26. Golla, J. A., Larson, L. A., Anderson, C. F., Luca, S. A. R., Wilson, W. R. and Tomasi, T. B. (1981) An immunological assessment of patients with anorexia nervosa. American Journal of Clinical Nutrition 34, 2756-2762.
27. Gormley, G. J., Lowy, M. T., Reder, A. T., Hospelhorn, V. D., Antel, J. P. and Meltzer, H. Y. (1985) Glucocorticoid receptors in depression: relationship to dexamethasone suppression test. American Journal of Psychiatry 142, 1278-1284.
28. Hamilton, A. (1960) A rating scale for depression. Journal of Neurology Neurosurgery Psychiatry 23, 56-62.
29. Heijnen, C. J., Zijlstra, J., Kavelaars, A., Croiset, G. and Ballieux, R. E. (1987) Modulation of the immune response by POMC-derived peptides. Influence on proliferation of human lymphocytes. Brain Behavior Immunity 1, 284-291.
30. Holsboer, F., Doerr, H. G., Gerken, A., Müller, O. A. and Sappell, W. E. (1984) Cortisol, 11-deoxycortisol and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers. Psychiatry Research 17, 15-23.
31. Hotta, M., Shibasaki, A., Masuda, A., Imaki, T., Demura, M., Ling, N. and Shizume, K. (1986) The response of adrenocorticotropin releasing hormone (CRH) and cerebrospinal fluid immunoreactive CRH in anorexia nervosa patients. Journal of Clinical Endocrinology and Metabolism 62, 319-324.
32. Hsueh, C. M., Tyrine, S. K., Hiramoto, R. N. and Ghanta, V. K. (1994) Efferent signal(s) responsible for the conditioned augmentation of natural killer cell activity. Neuroimmunomodulation 7, 74-81.
33. Imura, H., Fukata, J. and Mori, T. (1991) Cytokines and endocrine function: an interaction between the immune and the neuroendocrine systems. Clinical Endocrinology 35, 107-115.
34. Kaye, W.H. (1996) Neuropeptide abnormalities in Anorexia Nervosa. Psychiary Research 62, 65-74.
35. Kaye, W. H., Gwirtsman, H. E., George, D. T., Ebert, M. H., Jimerson, D. C., Tomai, T. P., Chrousos, G. P. and Gold, P. W. (1987) Elevated cerebrospinal fluid levels of immunoreactive Corticotropin - Releasing Hormone in Anorexia Nervosa: relation to state of nutrition, adrenal function, and intensity of depression. Journal of Clinical Endocrinology and Metabolism 64, 203-208.
36. Kavelaars, A., Ballieux, R. E. and Heijnen, C. J. (1990) β-endorphin secretion and lymphocyte proliferative response in anorexia nervosa patients. Neuroendocrinology Letters 13, 204.
37. Kontula, K., Anderson, L. C., Huttunen, M. and Pelkonen, R. (1982) Reduced level of cellular glucocorticoid receptor in patients with anorexia nervosa. Hormones and Metabolism Research 14, 619-620.
38. Korzeniewsky, K. and Callewaert, D. M. (1983) An enzyme-release assay for natural cytotoxicity. Journal of Immunological Methods 64, 313-320.
39. Licinio, J., Wong, M. and Gold, P. W. (1996) The Hypothalamic - Pituitary - Adrenal axis in Anorexia Nervosa. Psychiatry Research 62, 75-83.
40. Maes, M., Meltzer, H. Y., Stewens, W., Calabrese, J. and Cosyns, P. (1994) Natural Killer cell activity in major depression: Relation to Natural Killer cells, cellular indices of the immune response, and depressive phenomenology. Progress in NeuroPsychopharmacology Biological Psychiatry 18, 717-730.
41. Mandler, R. N., Biddison, W. E., Mandler, R. and Serrate, S. A. (1986) β-endorphin augments the cytolytic activity and interferon production of natural killer cells. Journal of Immunology 136, 934-939.
42. Mathews, P. M., Froehlich, C. J., Sibbit, W. L. and Bankhurst, A. D. (1983) Enhancement of natural cytotoxicity by beta-endorphin. Journal of Immunology 130, 1658-1664.
43. McGlone, J. J., Lumpkin, E. A. and Norman, L. R. (1991) Adrenocorticotropin stimulates natural killer cell activity. Endocrinology 129, 1653-1658.
44. Nerozzi, D., Santoni, A., Bersani, G., Magnani, A., Bressan, A., Pasini, A., Antonozzi, I. and Frajese, G. (1989) Reduced natural killer cell activity in major depression. Psychoneuroendocrinology 14, 295-301.
45. Näsman, B., Olsson, T., Seckl, J. R., Eriksson, S., Viitanen, M., Bucht, G. and Carlström, K. (1995) Abnormalities in adrenal androgens, but not of glucocorticoids, in early Alzheimer's disease. Psychoneuroendocrinology 20, 83-94.
46. Parrillo, J. E. and Fauci, A. S. (1978) Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids. Scandinavian Journal of Immunology 8, 99-108.
47. Pross, H. F., Baines, M. G., Rubin, P., Schagge, P. and Patterson, M. S. (1981) Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of human natural killer cell activity. Journal of Clinical Immunology 1, 52-59.
48. Raulet, D. H. (1995) Recognition events that inhibit and activate Natural Killer cells. Current Opinions in Immunology 8, 372-377.
49. Robertson, M. J. and Ritz, J. (1990) Biology and clinical relevance of human natural killer cells. Blood 76, 2431-2438.
50. Roy, A., Pickar, D., Paul, S. M., Duran, A., Chrousos, G. P. and Gold, P. W. (1987) CSF-corticotropin releasing hormone in depressed patients and normal controls. American Journal of Psychiatry 144, 641-645.
51. Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P. and Vale, W. (1987) lnterleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science 238, 524-536.
52. Scanlan, J. M., Werner, J. J., Legg, R. L. and Laudenslager, M. L. (1995) Natural Killer cell activity is reduced in association with oral contraceptive use. Psychoneuroendocrinology 20, 281-287.
53. Schattner, A. (1990) TNF, interferon-gamma and cell-mediated cytotoxicity in anorexia nervosa; effect of refeeding. Journal of Clinical and Laboratory Immunology 32(Suppl. 4), 183-184.
54. Schattner, A., Steinbock, M., Tepper, R., Schönfeld, A., Vaisman, H. and Hahn, T. (1990) Tumor necrosis factor production and cell-mediated immunity in anorexia nervosa. Clinical and Experimental Immunology 79, 62-66.
55. Schlechte, J. A. and Sherman, B. M. (1985) Lymphocyte glucocorticoid receptor binding in depressed patients with hypercortisolemia. Psychoneuroendocrinology 10, 469-474.
56. Schweitzer, I., Szmukler, G. I., Maguire, K. P., Harrison, L. C., Tuckwell, V. and Davies, B. M. (1990) The dexamethasone suppression test in anorexia nervosa. The influence of weight, depression, adrenocorticotropic hormone and dexamethasone. British Journal of Psychiatry 157, 713-717.
57. Scott, P. and Trinchieri, G. (1995) The role of Natural Killer cells in host-parasite interactions. Current Opinions in Immunology 7, 34-40.
58. Spielberger, C.D. (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo Alto.
59. Trinchieri, G. (1989) Biology of Natural Killer cells. Advances in Immunology 47, 187-386.
60. White, D., Jones, D. B., Cook, T. R. and Kirkham, N. (1982) Natural Killer (NK) activity in peripheral blood lymphocytes of patients with benign and malignant breast disease. British Journal of Cancer 46, 611-616.
61. Wilder, R.L. (1995) Neuroendocrine - immune system interactions and autoimmunity. Annual Review of Immunology 13, 307-338.