Dependence of the adaptive immune response on innate immunity: Some questions answered but new paradoxes emerge

Immunology and Cell Biology

Volumn 75, Issue 6, 1997, Pages 523-527

  Parish, Christopher R ^a   O'Neill, Erin R ^a  

^a Australian National University   (Australia)

Author keywords

Adaptive immunity; Autoimmunity; Costimulation; Immunological memory; Innate immunity; Self non self discrimination; Signal minus 1

Indexed keywords

ADJUVANT; B LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; AUTOIMMUNITY; B LYMPHOCYTE; EFFECTOR CELL; GENE MUTATION; HUMAN; IMMUNE RESPONSE; IMMUNITY; IMMUNOLOGICAL MEMORY; INFECTION RESISTANCE; NONHUMAN; REINFECTION; REVIEW; T LYMPHOCYTE;

VERTEBRATA;

EID: 0031409287     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1038/icb.1997.83     Document Type: Review

References (30)

1. Janeway CA. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 1989; 54: 1-13.
2. Janeway CA. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 1992; 13: 11-16.
3. Fearon DT, Locksley RM. The instructive role of innate immunity in the acquired immune response. Science 1996; 272: 50-4.
4. Janeway CA, Goodnow CC, Medzhitov R. Immunological tolerance: Danger-pathogen on the premises! Curr. Biol. 1996; 6: 519-22.
5. Medzhilov R, Janeway CA. Innate immunity: Impact on the adaptive response. Curr. Opin. Immunol. 1997; 9: 4-9.
6. Bretscher P, Cohn M. A theory of self-nonself discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively. Science 1970; 163: 1042-9.
7. Bendelac A, Fearon DT (eds). Innate immunity. Curr. Opin. Immunol. 1997; 9: 1-69.
8. Holmskov U, Malhotra R, Sim RB, Jensenius JC. Collectins: Collagenous C-type lectins of the innate immune defense system. Immunol. Today 1994; 15: 67-74.
9. Turner MW. Mannose-binding lectin: The pluripotent molecule of the innate immune system. Immunol. Today 1996; 17: 532-40.
10. Stahl PD. The mannose receptor and other macrophage lectins. Curr. Biol. 1992; 4: 49-52.
11. Mosser DM. Receptors on phagocytes involved in microbial recognition. In: Zwilling BS, Eisenstein TK (eds). Macrophage-Pathogen Interactions. New York: Marcel Dekker, 1993; 99-114.
12. Manthey CL, Vogel SN. Interaction of lipopolysaccharide with macrophages. In: Zwilling BS, Eisenstein TK (eds). Macrophage-Pathogen Interactions. New York: Marcel Dekker, 1993; 63-81.
13. Gallin JI, Goldstein IM, Snyderman R. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press, 1992.
14. Baggiolini M, Dewald B, Moser B. Human chemokines: An update. Annu. Rev. Immunol. 1997; 15: 675-705.
15. Steel DM, Whitehead AS. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol. Today 1994; 15: 81-8.
16. Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 1994; 12: 991-1045.
17. Ruby J (ed.) Special feature: Immune evasion by pathogens. Immunol. Cell Biol. 1996; 74: 504-74.
18. May RM. How many species? Philos. Trans. R. Soc. Lond. B Biol. Sci. 1990; 330: 293-304.
19. Croft M, Bradley LM, Swain SL. Naive versus memory CD4 T cell response to antigen: Memory cells are less dependent on accessory cell costimulation and can respond to many antigen-presenting cell types including resting B cells. J. Immunol. 1994; 152: 2675-85.
20. Flynn K, Müllbacher A. Memory alloreactive cytotoxic T cells do not require costimulation for activation in vitro. Immunol. Cell Biol. 1996; 74: 413-20.
21. Kelsoe G. In situ studies of the germinal center reaction. Adv. Immunol. 1995; 60: 267-88.
22. H domains among the gnathanstomes. Immunol. Cell Biol. 1996; 74: 357-64.
23. Langman RE, Cohn M. A short history of time and space in immune discrimination. Scand. J. Immunol. 1996; 44: 544-8.
24. Finkelman FD, Lees A, Birnbaum R, Gause WC, Morris SC. Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. J. Immunol. 1996; 157: 1406-14.
25. Vella AT, McCormack JE, Linsley PS, Kappler JW, Marrack P. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 1995; 2: 261-70.
26. Kurts C, Heath WR, Carbone FR, Allison J, Miller JFAP, Kosaka H. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 1996; 184: 923-30.
27. Fowlkes BJ, Ramsdell F. T cell tolerance. Curr. Opin. Immunol. 1993; 5: 873-9.
28. Arnold B, Schönrich G, Hammerling GJ. Multiple levels of peripheral tolerance. Immunol. Today 1993; 14: 12-14.
29. Greenwood BM. Autoimmune disease and parasitic infections in Nigerians. Lancet 1968; ii: 380-2.
30. Parish CR. Signal minus 1: A key factor in immunological tolerance to tissue-specific self antigens? Immunol. Cell Biol. 1996; 74: 278-85.