Analysis of NMDA receptors in the human spinal cord

Experimental Neurology

Volumn 148, Issue 2, 1997, Pages 407-413

  Sundström, Erik ^a   Whittemore, Scott ^b   Mo, Li Li ^a   Seiger, Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Human spinal cord; Immunoblot; Immunoprecipitation; MK 801; N methyl D aspartate; Receptor binding

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ADULT; ARTICLE; BINDING KINETICS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; RECEPTOR BINDING; SPINAL CORD;

EID: 0031408938     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6691     Document Type: Article

References (47)

1. Adams S.-L., Foldes R. L., Kamboj R. K. HumanND. Biochim. Biophys. Acta. 1260:1995;105-108.
2. Beaton J. A., Stemsrud K., Monaghan D. T. Identification of a novelND. J. Neurochem. 59:1992;754-757.
3. Buller A. L., Larson H. C., Schneider B. E., Beaton J. A., Morrisett R. A., Monaghan D. T. The molecular basis of NMDA receptor subtypes: Native receptor diversity is predicted by subunit composition. J. Neurosci. 14:1994;5471-5484.
4. Chazot P. L., Coleman S. K., Cik M., Stephenson F. A. Molecular characterization ofND. J. Biol. Chem. 269:1994;24403-24409.
5. Ciabarra A. M., Sullivan J. M., Gahn L. G., Pecht G., Heinemann S., Sevarino K. A. Cloning and characterization of χ-1: A developmental regulated member of a novel class of the ionotropic glutamate receptor family. J. Neurosci. 15:1995;6498-6508.
6. Davar G., Hama A., Deykin A., Vos B., Maciewicz R. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res. 553:1991;327-330.
7. Dickenson A. H. A cure for wind up: NMDA receptor antagonists as potential analgesics. Trends Pharmacol. 11:1990;307-309.
8. Ebert B., Wong E. H. F., Krogsgaard-Larsen P. Identification of a novel NMDA receptor in rat cerebellum. Eur. J. Pharmacol. 208:1991;49-52.
9. Faden A. I., Ellison J. A., Noble L. J. Effects of competitive and non-competitive NMDA receptor antagonists in spinal cord injury. Eur. J. Pharmacol. 175:1990;165-174.
10. Goméz-Pinilla F., Tram H., Cotman C., Nieto-Sampedro M. Neuroprotective effect of MK-801 and U-50488H after contusive spinal cord injury. Exp. Neurol. 104:1989;118-124.
11. Grimwood S., Le Bourdellès B., Atack J. R., Barton C., Cockett W., Cook S. M., Gilbert E., Hutson P. H., McKernan R. M., Myers J., Ragan C. I., Wingrove P. B., Whiting P. J. Generation and characterisation of stable cell lines expressing recombinant humanND. J. Neurochem. 66:1996;2239-2247.
12. Hao J.-X., Watson B. D., Xu X.-J., Wiesenfeld-Hallin Z., Seiger Å., Sundström E. Protective effect of the NMDA antagonist MK-801 on photochemically induced spinal lesions in the rat. Exp. Neurol. 118:1992;143-152.
13. Headley P. M., Grillner S. Excitatory amino acids and synaptic transmission: the evidence for a physiological function. Trends Pharmacol. Sci. 11:1990;205-211.
14. Ikeda K., Nagasawa M., Mori H., Araki K., Sakimura K., Watanabe M., Inoue Y., Mishina M. Cloning and expression of the ε4 subunit of the NMDA receptor channel. FEBS Lett. 313:1992;34-38.
15. Ishii T., Moriyoshi K., Sugihara H., Sakurada K., Kadotani H., Yokoi M., Akazawa C., Shigemoto R., Mizuno N., Masu M., Nakanishi S. Molecular characterization of the family of theND. J. Biol. Chem. 268:1993;2836-2843.
16. Kutsuwada T., Kashiwabuchi N., Mori H., Sakimura K., Kushiya E., Araki K., Meguro H., Masaki H., Kumanishi T., Arakawa M., Mishina M. Molecular diversity of the NMDA receptor channel. Nature. 358:1992;36-41.
17. Laurie D. J., Seeburg P. H. Ligand affinities at recombinantND. Eur. J. Pharmacol. Mol. Pharmacol. 268:1994;335-345.
18. Le Bourdellès B., Wafford K. A., Kemp J. A., Marshall G., Bain C., Wilcox A. S., Sikela J. M., Whiting P. J. Cloning, functional coexpression, and pharmacological characterisation of human cDNAs encoding NMDA receptor NR1 and NR2A subunits. J. Neurochem. 62:1994;2091-2098.
19. Luque J. M., Bleuel Z., Malherbe P., Richards J. G. Alternatively spliced isoforms of theND. Neuroscience. 63:1994;629-635.
20. Markwell M. A. K., Haas S. M., Bieber L. L., Tolbert N. E. A modification of the standard Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87:1978;206-210.
21. Mayer M. L., Westbrook G. L. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28:1987;197-276.
22. Meguro H., Mori H., Araki K., Kushiya E., Kutsuwada T., Yamazaki M., Kumanishi T., Arakawa M., Sakimura K., Mishina M. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature. 357:1992;70-74.
23. Monaghan D. T., Beaton J. A. Quinolinate differentiates between forebrain and cerebellar NMDA receptors. Eur. J. Pharmacol. 194:1991;123-125.
24. Monaghan D. T., Olverman H. J., Nguyen L., Watkins J. C., Cotman C. W. Two classes ofND. Proc. Natl. Acad. Sci. USA. 85:1988;9836-9840.
25. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B., Seeburg P. H. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science. 256:1992;1217-1221.
26. Moriyoshi K., Masu M., Ishii T., Shigemoto R., Mizuno N., Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature. 354:1991;31-37.
27. 3. Neurosci. Lett. 93:1988;225-230.
28. Palmer A. M., Burns M. A. Preservation of redox, polyamine, and glycine modulatory domains of theND. J. Neurochem. 62:1994;187-196.
29. 3ND. J. Neural Transm. [Gen. Sect.]. 96:1994;1-8.
30. Perkins M. N., Stone T. W. Quinolinic acid: Regional variations in neuronal sensitivity. Brain Res. 259:1983;172-176.
31. 3. J. Neurochem. 58:1992;1001-1008.
32. Pin J.-P., Duvoisin R. Review - Neurotransmitter receptors. I. The metabotropic glutamate receptors: Structure and functions. Neuropharmacology. 34:1995;1-26.
33. 3. J. Neurochem. 53:1989;698-704.
34. 3. J. Neurochem. 54:1990;1163-1168.
35. 3ND. J. Neurochem. 56:1991;1731-1740.
36. 3. J. Neurochem. 60:1993;1344-1353.
37. Schaible H.-G., Grubb B. D., Neugebauer V., Oppman M. The effects of NMDA antagonists on neuronal activity in cat spinal cord evoked by acute inflammation in the knee joint. Eur. J. Neurosci. 3:1991;981-991.
38. 3. Brain Res. 539:1991;164-168.
39. Sheng M., Cummings J., Roldan L. A., Jan Y. N., Jan L. Y. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature. 368:1994;144-147.
40. 3. Eur. J. Pharmacol. 307:1996;347-353.
41. Sucher N. J., Akbarian S., Chi C. L., Leclerc C. L., Awobuluyi M., Deitcher D. L., Wu M. K., Yuan J. P., Jones E. G., Lipton S. A. Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J. Neurosci. 15:1995;6509-6520.
42. Tölle T. R., Berthele A., Zieglgänsberger W., Seeburg P. H., Wisden W. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13:1994;5009-5028.
43. Wafford K. A., Bain C. J., Le Bourdelles B., Whiting P. J., Kemp J. A. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. NeuroReport. 4:1994;1347-1349.
44. Wenthold R. J., Yokotani N., Doi K., Wada K. Immunochemical characterization of the non-NMDA glutamate receptor using subunit-specific antibodies: Evidence for a hetero-oligomeric structure in rat brain. J. Biol. Chem. 267:1992;501-507.
45. Yum S. W., Faden A. I. Comparison of the neuroprotective effects of theND. Arch. Neurol. 47:1990;277-281.
46. Zhang L., Zheng X., Paupard M.-C., Wang A. P., Santchi L., Friedman L. K., Zukin R. S., Bennett M. V. L. Spermine potentiation of recombinantND. Proc. Natl. Acad. Sci. USA. 91:1994;10883-10887.
47. Zukin R. S., Bennett M. V. L. Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends Neurosci. 18:1995;306-313.