Persisting learning deficits in rats after exposure to pfiesteria piscicida

Environmental Health Perspectives

Volumn 105, Issue 12, 1997, Pages 1320-1325

  Levin, Edward D ^a   Schmechel, Donald E ^a,b   Burkholder, JoAnn M ^c   Glasgow Jr , Howard B ^c   Deamer Melia, Nora J ^c   Moser, Virginia C ^d   Jean Harry, G ^e  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Dinoflagellates; Learning; Memory; Persisting; Pfiesteria; Radial arm maze; Toxic

Indexed keywords

WATER;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CELL COUNT; BRAIN FUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DINOFLAGELLATE; FEMALE; FISH; FOLLOW UP; FREEZING; HEALTH STATUS; INJECTION; KIDNEY FUNCTION; LABORATORY; LEARNING DISORDER; LEUKOCYTE COUNT; LUNG FUNCTION; MAZE TEST; MEMORY; NONHUMAN; OCCUPATIONAL ACCIDENT; PRIORITY JOURNAL; RAT; SPLEEN FUNCTION; TASK PERFORMANCE; THAWING; UNITED STATES; WATER SAMPLING;

ANIMALIA; DINOPHYCEAE; PFIESTERIA; PFIESTERIA PISCICIDA; PFIESTERIA-LIKE DINOFLAGELLATE; PROTOZOA;

EID: 0031407018     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.971051320     Document Type: Article

References (19)

1. Burkholder JM, Noga EJ, Hobbs CW, Glasgow HB Jr, Smith SA. New "phantom" dinoflagellate is the causative agent of major estuarine fish kills. Nature 358:407-410 (1992).
2. Burkholder JM, Glasgow HB Jr. Interactions of a toxic estuarine dinoflagellate with microbial predators and prey. Archiv Protistenk 145: 177-188 (1995).
3. Burkholder JM, Glasgow HB Jr. Pfiesteria piscicida and Pfisteria-like dinoflagellates: behavioral impacts and environmental controls. Limnol Oceanogr (in press).
4. Burkholder JM, Glasgow HB Jr, Noga EJ, Hobbs CW. The role of a new toxic dinoflagellate in finfish and shellfish kills in the Neuse and Pamlico Estuaries. In: Ablemarle-Pamlico Estuarine Study. Report Number 93-08. Raleigh, NC:North Carolina Department of Environmental Health and Natural Resourses and EPA National Estuarine Program, 1993;1-58.
5. McCellan-Green PD, Noga E, Baden D, Jaykus LA, Green DP. Cytotoxicity of a putative toxin from the Pfiesteria piscicida dinoflagellate. The Toxicologist 36:276 (1997).
6. Glasgow HB Jr, Burkholder JM, Schmechel DE, Tester PA, Rublee PA. Insidious effects of a toxic estuarine dinoflagellate on fish survival and human health. J Toxicol Environ Health 46:501-522 (1995).
7. Levin ED, Schmechel DE, Glasgow HB Jr, Burkholder JM, Deamer-Melia NM. Pfiesteria piscicida effects on cognitive performance in rats. Presented at the 1996 Meeting of the Southeastern Estuarine Research Society, 7 November 1996, Atlantic Beach, NC.
8. Levin ED, Schmechel DE, Glasgow HB Jr, Burkholder JM. Cognitive effects seen in rats exposed to the dinoflagellate Pfiesteria. The Texicologist 36:62 (1997).
9. Olton DS, Walker JA, Wolf WA. A disconnection analysis of hippocampal function. Brain Res 233:241-253 (1982).
10. Levin ED. Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Re 12:169-175 (1988).
11. Walsh TJ, Chrobak JJ. The use of the radial-arm maze in neurotoxicology. Physiol Behav 40:799-803 (1987).
12. Peele DB, Baron SP. Effects of scopolamine on repeated acquisition on radial-arm maze performance by rats. J Exp Anal Behav 49:275-290 (1988).
13. Bushnell PJ, Angell KE. Effects of trimethyltin on repeated acquisition (learning) in the radial-arm maze. Neurotoxicology 13:429-442 (1992).
14. Tilson HA, Moser VC. Comparison of screening approaches. Neurotoxicology 13:1-14 (1992).
15. Moser VC, McCormick JP, Creason JP, MacPhail RC. Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam Appl Toxicol 11:189-206 (1988).
16. McDaniel KL, Moser VC. Utility of a neurobehavioral screening battery for differentiating the effects of two pyrethroids, permethrin and cypermethrin. Neurotoxicol Teratol 15:71-83 (1993).
17. Keppel G. Design and Analysis: A Researcher's Handbook. Englewood Cliffs, NJ:Prentice-Hall, Inc, 1973.
18. Creason J. Data evaluation and statistical analysis of functional observational battery data using a linear models approach. J Am Coll Toxicol 8:157-170 (1989).
19. SAS Institute. SAS/STAT User's Guide, Version 6. Gary, NC:SAS Institute Inc., 1990.