Measuring bias in uncontrolled brain tumor trials - To randomize or not to randomize?

Canadian Journal of Neurological Sciences

Volumn 24, Issue 4, 1997, Pages 307-312

  Irish, William D ^a   Macdonald, David R ^b,c   Cairncross, J Gregory ^b,c  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN SURGERY; CANCER RADIOTHERAPY; CANCER SURVIVAL; FEMALE; GLIOMA; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PATIENT SELECTION; PRIORITY JOURNAL; PROGNOSIS; RADIOSURGERY; STATISTICAL ANALYSIS; TREATMENT OUTCOME; TREATMENT PLANNING;

EID: 0031406011     PISSN: 03171671     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0317167100032972     Document Type: Article

References (12)

1. Winger MJ, Macdonald DR, Schold SC, Cairncross JG. Selection bias in clinical trials of anaplastic glioma. Ann Neurol 1989; 26: 531-534.
2. Florell RC, Macdonald DR, Irish WD, et al. Selection bias, survival, and brachytherapy for glioma. J Neurosurg 1992; 76: 179-183.
3. Kirby S, Brothers M, Irish W, et al. Evaluating glioma therapies -modeling treatments and predicting outcomes. J Natl Cancer Inst 1995; 87: 1884-1888.
4. Loeffler JS, Alexander E, Shea WM, et al. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol 1992; 10: 1379-1385.
5. Loeffler JS, Shrieve DC, Wen PY, et al. Radiosurgery for intracranial malignancies. Sem Radiat Oncol 1995; 5: 225-234.
6. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 437-481.
7. Breslow NE. A generalized Kurskel-Wallis test for comparing K samples subject to unequal patterns of censorship. Biometrika 1970; 57: 579-594.
8. Curran WJ, Scott CB, Horton J, et al. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst 1993; 85: 704-710.
9. Curran WJ, Scott CB, Weinstein AS, et al. Survival comparison of radiosurgery-eligible and -ineligible malignant glioma patients treated with hyperfractionated radiation therapy and carmustine: a report of Radiation Therapy Oncology Group 83-02. J Clin Oncol 1993; 11: 857-862.
10. Sarkaria MD, Mehta MP, Loeffler JS, et al. Radiosurgery in the initial management of malignant gliomas: survival comparison with the RTOG recursive partitioning analysis. Int J Radiat Oncol Biol Phys 1995; 32: 931-941.
11. Shapiro WR, Green SB, Burger PC, et al. A randomized comparison of intra-arterial versus intravenous BCNU, with or without intravenous 5-fluorouracil, for newly diagnosed patients with malignant glioma. J Neurosurg 1992; 76: 772-781.
12. Shapiro WR, Green S, Burger P, et al. A randomized trial of interstitial radiotherapy (IRT) boost for the treatment of newly diagnosed malignant glioma (glioblastoma multiforme, anaplastic astrocytoma, anaplastic oligodendroglioma, malignant mixed glioma): BTCG Study 8701. Neurology 1994; 44 (Suppl 2): A263.