Comparison of cyclophilin binding assay and radioimmunoassay in monitoring of blood cyclosporine

Therapeutic Drug Monitoring

Volumn 19, Issue 4, 1997, Pages 446-449

  Huupponen, Risto ^a   Hirvisalo, Eeva Liisa ^b   Neuvonen, Pertti ^b  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Cyclophilin; Cyclophilin binding; Cyclosporine; Radioimmunoassay; Therapeutic drug monitoring

Indexed keywords

CYCLOPHILIN; CYCLOSPORIN; CYCLOSPORIN A;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MONITORING; DRUG PROTEIN BINDING; HUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RELIABILITY;

AMINO ACID ISOMERASES; CARRIER PROTEINS; CYCLOSPORINE; DRUG MONITORING; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PEPTIDYLPROLYL ISOMERASE; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY;

EID: 0031405640     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199708000-00014     Document Type: Article

References (17)

1. Fahr A. Cyclosporin clinical pharmacokinetics. Clin Pharmacokin 1993;24:472-495.
2. Agarwal RP, Threatte GA, McPherson RA. Temperature-dependent binding of cyclosporine to an erythrocyte protein. Clin Chem 1987;33:481-485.
3. Kivistö KT. A review of assay methods for cyclosporin. Clinical implications. Clin Pharmacokin 1992;23:173-190.
4. Lorber MI, Paul K, Harding MW, Handschumacher RE, Marks WH. Cyclophilin binding: a receptor mediated approach to monitoring cyclosporine immunosuppressive activity following organ transplantation. Transplant Proc 1990;22:1240-1244.
5. Russel RL, Donnelly JG, Palaszynski EW, Chan MM, Soldin SJ. A preliminary study to evaluate an in vitro assay for determining patient whole blood immunosuppressive cyclosporine A and metabolite activity: comparison with cytosolic binding assays using cyclophilin or a 50-kilodalton binding protein and the Abbott Tdx cyclosporine A parent and parent and metabolites assays. Ther Drug Monit 1991;13:32-36.
6. Soldin SJ, Murthy JN, Donnelly JG, Chen Y, Goodyear N. Immunophilin receptors for immunosuppressive drugs. Ther Drug Monit 1993;15:468-471.
7. Wiederrecht G, Lam E, Hung S, Martin M, Sigal N. The mechanism of action of FK-506 and cyclosporin A. Ann N Y Acad Sci 1993;696:9-19.
8. Clipstone NA, Crabtree GR. Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. Ann N Y Acad Sci 1993;696: 20-30.
9. Fahr A, Hiestand P, Ryffel B. Studies on the biological activities of Sandimmun metabolites in humans and in animal models: review and original experiments. Transplant Proc 1990;22:1116-1124.
10. Freed BM, Rosano TG, Lempert N. In vitro immunosuppressive properties of cyclosporine metabolites. Transplant 1987;43:123-127.
11. Rosano TG, Freed BM, Cerilli J, Lempert N. Immunosuppressive metabolites of cyclosporine in the blood of renal allograft recipients. Transplant 1986;42:262-267.
12. Steiner G, K̈llinger B, Mayer G, Jie Y, Leibl H, Kovarik J, Woloszczuk W. Determination of cyclosporine by a competitive binding assay with cyclophilin. Clin Chem 1991;37:403-410.
13. Morris RG, Tett SE, Ray JE. Cyclosporin A monitoring in Australia: consensus recommendations. Ther Drug Monit 1994;16:570-576.
14. Soldin SJ. Receptor (immunophilin-binding) assay for immunosuppressive drugs. Ther Drug Monit 1995;17:574-576.
15. Donnelly JG, Soldin SJ. A radioreceptor assay for the measurement of cyclosporine activity: a preliminary report. Ther Drug Monit 1989;11:696-700.
16. Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. J Clin Pharmacol 1994;34:60-67.
17. Webber JR, Peters WHM, Back DJ. Cyclosporin metabolism by human gastrointestinal mucosal microsomes. Br J Clin Pharmacol 1992;33:661-664.