Inulin hydrogels as carriers for colonic drug targeting: I. Synthesis and characterization of methacrylated inulin and hydrogel formation

Pharmaceutical Research

Volumn 14, Issue 12, 1997, Pages 1730-1737

  Vervoort, Liesbeth ^a   Van Den Mooter, Guy ^a   Augustijns, Patrick ^a   Busson, Roger ^a   Toppet, Suzanne ^a   Kinget, Renaat ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Glycidyl methacrylate; Hydrogels; Inulin; NMR spectroscopy

Indexed keywords

AMINOPYRIDINE DERIVATIVE; INULIN; METHACRYLIC ACID DERIVATIVE; N,N DIMETHYLFORMAMIDE;

AQUEOUS SOLUTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; ESTERIFICATION; HYDROGEL; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

4-AMINOPYRIDINE; DIMETHYLFORMAMIDE; DRUG CARRIERS; EPOXY COMPOUNDS; ESTERIFICATION; GELS; INULIN; MAGNETIC RESONANCE SPECTROSCOPY; METHACRYLATES; POLYMERS;

EID: 0031404653     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012179813102     Document Type: Article

References (25)

1. J. Van Loo, P. Coassement, L. De Leenheer, H. Hoebregs, and G. Smits. Crit. Rev. Food Sci. Nutr. 36:525-552 (1995).
2. P. Dysseler and D. Hoffem. Eur. J. Clin. Nutr. 49:S145-S152 (1995).
3. G. R. Gibson and M. B. Roberfroid. J. Nutr. 125:1401-1414 (1995).
4. M. B. Roberfroid. Crit. Rev. Food Sci. Nutr. 33:103-148 (1993).
5. X. Wang and G. R. Gibson. J. Appl. Bact. 75:373-380 (1993).
6. R. C. McKellar and H. W. Modler. Appl. Microbiol. Biotechnol. 31:537-541 (1989).
7. G. R. Gibson, C. L. Willis, and J. Van Loo. Inc. Sugar J. 96 (1994).
8. E. Harboe, C. Larsen, M. Johansen, and H. P. Olesen. Pharm. Res. 6:919-923 (1989).
9. K. O. R. Lehmann and K. D. Dreher. Proceed Intern. Symp. Control. Rel. Bioact. Mater. 18:331-332 (1991).
10. G. Van den Mooter, C. Samyn, and R. Kinget. Int. J. Pharm. 87:37-46 (1992).
11. A. Rubinstein, R. Radai, M. Ezna, and S. Pathnack. Pharm. Res. 10:258-263 (1993).
12. L. Hovgaard and H. Brondsted. J. Contr. Rel. 36:159-166 (1995).
13. J. Kopecek, P. Kopeckova, H. Brondsted, R. Rathi, B. Rihova, P. Y. Yeh, and K. Ikesue. J. Contr. Rel. 19:121-130 (1992).
14. L. Vervoort and R. Kinget. Int. J. Pharm. 129:185-190 (1996).
15. W. N. E. van Dijk-Wolthuis, O. Franssen, H. Talsma, M. J. van Steenbergen, J. J. Kettenes-van den Bosch, and W. E. Hennink. Macromolecules 28:6317-6322 (1995).
16. Belgian Pharmacopoeia, sixth ed., VII. 1.1 (1987).
17. W. Van Den Ende, A. Mintiens, H. Speleers, A. A. Onuoha, and A. Van Laere. New Phytol. 132:555-563 (1996).
18. X. D. Feng, X. Q. Guo, and K. Y. Qiu. Makromol. Chem. 189:77-83 (1988).
19. 1H FT NMR spectra, Aldrich Chemical Company, 1993, vol I p 341 A.
20. J. Vermeersch and E. Schacht. Makromol. Chem. 187:125-131 (1986).
21. A. De Bruyn and J. Van Loo. Carbohydr. Res. 211:131-136 (1991).
22. J. W. Timmermans, P. de Waard, H. Tournois, B. R. Leeflang and J. F. G. Vliegenthart. Carbohydr. Res. 243:379-384 (1993).
23. D. Wang, L. Carrera, and M. J. M. Abadie. Eur. Polym. J. 29:1379-1386 (1993).
24. H. Kazmarek and C. Decker. J. Appl. Polym. Sci. 54:2147-2156 (1994).
25. E. Pretsch. Tabellen zur structuraufklärung organischer Verbindungen mit spektroskopischen methoden, Springer-Verlag, Berlin Heidelberg New York, 1976, p C170.