Suppression of arousal by progesterone in fetal sheep

Reproduction, Fertility and Development

Volumn 9, Issue 8, 1997, Pages 767-773

  Crossley, Kelly J ^a   Nicol, Marcus B ^a   Hirst, Jonathan J ^a   Walker, David W ^a   Thorburn, Geoffrey D ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROGESTERONE; TRILOSTANE;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; ELECTROCORTICOGRAPHY; ELECTROMYOGRAPHY; ELECTROOCULOGRAPHY; FETUS; FETUS DEVELOPMENT; NONHUMAN; PROGESTERONE BLOOD LEVEL; PROGESTERONE SYNTHESIS; WAKEFULNESS;

3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; AROUSAL; BRAIN; DIHYDROTESTOSTERONE; ELECTROMYOGRAPHY; ENZYME INHIBITORS; FEMALE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PROGESTERONE; SHEEP; SLEEP;

ANIMALIA; OVIS; OVIS ARIES;

EID: 0031403690     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/R97074     Document Type: Article

References (33)

1. Ainsworth, L. and Ryan, K. J. (1967). Steroid hormone transformations by endocrine organs from pregnant mammals II. Formation and metabolism of progesterone by bovine and sheep placental preparations in vitro. Endocrinology 81, 1349-56.
2. Bassett, J. M., Oxborrow, T. J., Smith, I. D., and Thorburn, G. D. (1969). The concentration of progesterone in the peripheral plasma of the pregnant ewe. J. Endocrinol. 45, 449-57.
3. Bedford, C. A., Challis, J. R., Harrison, F. A., and Heap, R. B. (1972). The role of oestrogens and progesterone in the onset of parturition in various species. J. Reprod. Fertil. Suppl. 197, 123.
4. Bocking, A.D., and Harding, R. (1986). Effects of reduced uterine blood flow on electrocortical activity, breathing, and skeletal muscle activity in fetal sheep. Am. J. Obstet. Gynecol. 154, 655-62.
5. Carl, P., Hogskilde, S., Lang-Jensen, T., Bach, V., Jacobsen, J., Sorensen, M. N., Grallis, M., and Widlund, L. (1994). Pharmacokinetics and pharmacodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesth. Scand. 38, 734-41.
6. Crenshaw, M. C., Meschia, G., and Barron, D. H. (1966). Role of progesterone in inhibition of muscle tone and respiratory rhythm in fetal lambs. Nature (Lond.) 212, 842.
7. A receptors in the fetal and neonatal ovine brain. Proc. Aust. Neuro. Soc. 9, 142.
8. Dawes, G. S., Fox, H. E., Leduc, B. M., Liggins, G. C., and Richards, R. T. (1972). Respiratory movements and rapid eye movement sleep in the foetal lamb. J. Physiol. (Lond.) 220, 119-43.
9. Dolling, M. and Seamark, R. F. (1979). Progesterone metabolites in fetal sheep plasma: the effect of fetal nephrectomy. J. Dev. Physiol. (Oxf.) 1, 399-413.
10. Harrison, N. L., Majewska, M. D., Harrington, J. W., and Barker, J. L. (1987). Structure-activity relationships for steroid interaction with the GABA receptor complex. J. Pharmacol. Exp. Ther. 241, 346-53.
11. Harrison, N. L. and Simmonds, M. A. (1984). Modulation of the GABAA receptor complex by a steroid anaesthetic. Brain Res. 323, 287-92.
12. Ioffe, S., Jansen, A. H., Russell, B. J., and Chernick, V. (1980). Sleep, wakefulness and the monosynaptic reflex in fetal and newborn lambs. Pflügers Arch. 388, 149-57.
13. Jenkin, G. and Thorburn, G. D. (1985b). Inhibition of progesterone secretion by a 3 beta-hydroxysteroid dehydrogenase inhibitor in late pregnant sheep. Can. J Physiol. Pharmacol. 63, 136-42.
14. Jenkin, G., Jorgenson, G., Thorburn, G. D., Buster, J. E., and Nathanielsz, P. W. (1985a). Induction of premature delivery in sheep following infusion of cortisol to the fetus. I. The effect of maternal administration of progestagens. Can. J. Physiol. Pharmacol. 63, 500-8.
15. Johnston, B. M. and Gluckman, P. D. (1983). GABA mediated inhibition of breathing in the late gestation sheep fetus. J. Dev. Physiol. 5, 353-60.
16. MacDonald, P. C., Dombroski, R. A., and Casey, M. L. (1991). Recurrent secretion of progesterone in large amounts: an endocrine/metabolic disorder unique to young women? Endocr. Rev. 12, 372-401.
17. Majewska, M. D., Harrison, N. L., Schwartz, R. D., Barker, J. L., and Paul, S. M. (1986). Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232, 1004-7.
18. McLeod, W., Brien, J., Loomis, C., Probert, C., and Patrick, J. (1983). Effect of maternal ethanol ingestion on fetal breathing movements, gross body movements, and heart rate at 37 to 40 weeks' gestational age. Am. J. Obstet. Gynecol. 145, 251-7.
19. Merryman, W., Boiman, R., Barnes, L., and Rothchild, I. (1954). Progesterone 'anaesthesia' in human subjects. J. Clin. Endocrinol. & Metab. 14, 1567-69.
20. Nancarrow, C. D. and Seamark, R. F. (1968). Progesterone metabolism in fetal blood. Steroids 12, 367-79.
21. Nicol, M. B., Hirst, J. J., Walker, D., and Thorburn, G. D. (1997). Effect of alteration of maternal plasma progesterone concentrations on fetal behavioural state during late gestation. J. Endocrinol. 152, 379-86.
22. Patrick, J., Richardson, B., Hasen, G., Clarke, D., Wlodek, M., Bousquet, J., and Brien, J. (1985). Effects of maternal ethanol infusion on fetal cardiovascular and brain activity in lambs. Am. J. Obstet. Gynecol. 151, 859-67.
23. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 94, 1257-69.
24. Phillipps, G. H. (1975). Structure-activity relationships in steroidal anaesthetics. J. Steroid Biochem. 6, 607-13.
25. Powell, II., Morgan, M., and Sear, J. W. (1992). Pregnanolone: a new steroid intravenous anaesthetic. Dose-finding study. Anaesthesia 47, 287-90.
26. Purdy, R. H. and Paul, S. M. (1992). Neuroactive steroids. J. FASEB 6, 2311-22.
27. Rice, G. E., Jenkin, G., and Thorburn, G. D. (1986). Comparison of particle-associated progesterone and oxytocin in the ovine corpus luteum. J. Endocrinol. 108, 109-16.
28. Richardson, B. S., Carmichael, L., Homan, J., and Patrick, J. E. (1992). Electrocortical activity, electroocular activity, and breathing movements in fetal sheep with prolonged and graded hypoxemia. Am. J. Obstet Gynecol. 167, 553-8.
29. Ruckebusch, Y. (1972). Development of sleep and wakefulness in the foetal lamb. Electroencephalography Clin. Neurophysiol. 32, 119-28.
30. Seamark, R. F., Nancarrow, C. D., and Gardner, J. (1970). Progesterone metabolism in ovine blood: the formation ot 3 alpha-hydroxy-pregn-4-en-20-one and other substances. Steroids 15, 589-604.
31. Szeto, H. H., and Hinman, D. J. (1985). Prenatal development of sleep-wake patterns in sheep. Sleep 8, 347-55.
32. Turner, D. M., Ransom, R. W., Yang, S., and Olsen, R. W. (1989). Steroid anaesthetics and naturally occurring analogs modulate the GABAA receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther. 248, 960-6.
33. 3H-diazepam binding. Paediatr. Pharmacol. 2, 179-87.