Optimization of sustained-release tablet formulations: A four-component mixture experiment

Pharmaceutical Development and Technology

Volumn 2, Issue 4, 1997, Pages 365-371

  Hariharan, Madhusudan ^a   Gupta, Vishal ^a   Price, James C ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Cross linked carboxymethylcellulose sodium; Response surface methodology; Simultaneous optimization; Sustained release; Zero order release; Carrageenan

Indexed keywords

CARBOXYMETHYLCELLULOSE; CHLORPHENIRAMINE MALEATE;

ARTICLE; DRUG FORMULATION; DRUG RELEASE; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; TABLET;

EID: 0031402362     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459709022635     Document Type: Article

References (12)

1. K. K. Levinson, K. Takyama, K. Isowa, and T. Nagai, Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers, J. Pharm. Sci., 83(9), 1367-1372 (1994).
2. K. Abu-Izzah, L. Garcia-Contreras, and D. R. Lu, Preparation and optimization of sustained release AZT-loaded microspheres: Optimization of the release characteristics using response surface methodology, J. Pharm. Sci., 85(2), 144-149 (1996).
3. J. B. Schwartz, J. R. Flamholz, and R. H. Press, Computer optimization of pharmaceutical formulations I: General procedure, J. Pharm. Sci, 62(7), 1165-1170 (1973).
4. M. Hirata, K. Takayama, and T. Nagai, Formulation optimization of sustained-release tablet of chlorpheniramine maleate by means of extreme vertices design and simultaneous optimization technique, Chem. Pharm. Bull., 40(3), 741-746 (1992).
5. A. I. Khuri, and J. A. Cornell, Response Surfaces. Design and Analyses, Marcel Dekker, New York, 1987.
6. D. Vojnovic, M. Moneghini and D. Chicco, Nonclassical experimental design applied in the optimization of a placebo granulate formulation in high-shear mixer, Drug Dev. Ind. Pharm., 22(9&10), 997-1004 (1996).
7. M. C. Bonferoni, S. Rossi, M. Tamayo, J. L. Pedraz, A. Dominguez-Gil, and C. Caramella, On the employment of γ-carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethyl cellulose and xanthan gum, J. Controlled Release 26, 119-127 (1993).
8. H. Nakagami and M. Nada, The use of micronized cellulose disintegrants as insoluble swellable matrices for sustained-release tablets, Drug Design and Delivery, 7, 321-332 (1991).
9. M. Bamba, F. Puisieux, J. P. Marty and J. T. Cartensen, Release mechanisms in gelforming sustained release preparations, Int. J. Pharm., 2, 307-315 (1979).
10. N. A. Peppas, Analysis of Fickian and non-Fickian drug release from polymers, Pharm. Acta Helv., 60, 110-111 (1985).
11. A. I. Khuri and M. Conlon, Simultaneous optimization of multiple responses presented by polynomial regression functions, Technometrics, 23, 363-375 (1981).
12. K. Takyama, and T. Nagai, Simultaneous optimization for several characteristics concerning percutaneous absorption and skin damage of ketoprofen hydrogels containing d-limonene. Int. J. Pharm., 74, 115 (1991).