Effect of sub-inhibitory concentration of chlorhexidine on lipid and sterol composition of Candida albicans

Mycopathologia

Volumn 140, Issue 2, 1997, Pages 69-76

  Abu Elteen, Khaled H ^a,c   Whittaker, Peter A ^b  

^a Al Zaytoonah University

^b ST PATRICK S COLLEGE   (Ireland)

^c AL ZAYTOONAH UNIVERSITY OF JORDAN   (Jordan)

Author keywords

Chlorhexidine; Ergosterol Candida albicans; Fatty acid; Phospholipids

Indexed keywords

CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; DRUG DERIVATIVE; FATTY ACID; LIPID; STEROL; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; CANDIDA ALBICANS; CHEMISTRY; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; LIPID METABOLISM; METABOLISM; THIN LAYER CHROMATOGRAPHY;

ANTI-INFECTIVE AGENTS, LOCAL; CANDIDA ALBICANS; CHLORHEXIDINE; CHROMATOGRAPHY, THIN LAYER; FATTY ACIDS; LIPID METABOLISM; LIPIDS; STEROLS;

CANDIDA ALBICANS;

EID: 0031402162     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006852207366     Document Type: Article

References (40)

1. Hugo WB, Russell AD. Types of antimicrobial agents. In: Russell AD, Hugo WB, Ayliffe GA (eds.) Principles and Practice of Disinfection, Preservation and Sterilization. Oxford: Blackwell Scientific, 1982: 8-106.
2. Budtz-Jorgensen E, Loe H. Chlorhexidine as a denture disinfectant in the treatment of denture stomatitis. Scand J Dent Res 1975; 80: 457.
3. Olsen I. Denture stomatitis. Effects of chlorhexidine and amphotericin B on the mycotic flora. Acta Odontol Scand 1975; 33: 41-46.
4. Langslet A, Olsen I, Lie SO, Lokken P. Chlorhexidine treatment of oral candidiasis in seriously diseased children. Acta Paediat Scand 1974; 63: 809-811.
5. Sharon A, Berdicevsky I, Ben-Aryeh H, Gutman D. The effect of chlorhexidine mouth rinses on oral Candida in a group of leukemic patients. Oral Surg 1977; 44: 201-205.
6. McCourtie J, MacFarlane TW, Samaranayake LP. Effect of chlorhexidine gluconate on the adherence of Candida species to denture acrylic. J Med Microbiol 1985; 20: 97-104.
7. McCourtie J, MacFarlane TW, Samaranayake LP. A comparison of the effects of chlorhexidine gluconate, amphotericin B and nystatin on the adherence of Candida species to denture acrylic. J. Antimicrob Chemother 1986; 17: 575-583.
8. Tobgi RS, Samaranayake LP, MacFarlane TW. Adhesion of Candida albicans to buccal epithelial cells exposed to chlorhexidine gluconate. J Med Vet Mycol 1987; 25: 335-338.
9. Hugo WB, Longworth AR. Some aspects of the mode of action of chlorhexidine. J Pharm Pharmacol 1964; 16: 655-662.
10. Hugo WB, Longworth AR. Effect of chlorhexidine on protoplasts and spheroplasts of Escherichia coli, protoplasts of Bacillus megaterium and Gram staining reaction of Staphylococcus aureus. J Pharm Pharmacol 1964; 16: 751-758.
11. Hugo WB, Longworth AR. The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell wall of Escherichia coli and Staphylococcus aureus. J Pharm Pharmacol 1966; 18: 569-578.
12. Davies A, Bentley M, Field BS. Comparison of the action of vantocil, cetrimide and chlorhexidine on Escherichia coli and its spheroplasts and the protoplasts of Gram positive bacteria. J Appl Bacteriol 1968; 31: 448-461.
13. Bobichon H, Bouchet P. Action of chlorhexidine on budding Candida albicans: scanning and transmission electron microscopic study. Mycopathologia 1987:100: 27-35.
14. Kerridge D, Koh TY, Marriott MS, Gale EF. The production and properties of protoplasts from the dimorphic yeast Candida albicans, In: Peberdy JF, Rose AH, Rogers HJ, Cocking EC (eds.) Microbial and Plant Protoplasts. London: Academic Press, 1976: 23-38.
15. Marriott MS. Isolation and chemical characterisation of plasma membranes from the yeast and mycelial forms of Candida albicans. J. Gen Microbiol 1975; 86: 115-132.
16. Ghannoum MA, Radwan SS. Candida Adherence to Epithelial Cells. Florida: CRC press Inc, 1990: Ch. 4.
17. Ghannoum MA, Motawy MS, Al-Mubarek AL, Al-Awadhi HA. Candida albicans strain differentiation in cancer patients undergoing therapy. Mykosen 1985; 28: 388-393.
18. Ghannoum MA, Motawy MS, Al-Mubarek AL, Al-Awadhi HA. Incidence and susceptibility of yeasts isolated from cancer patients in Kuwait. Mykosen 1985; 28: 619-624.
19. Hitchcock CA, Barrett-Bee KJ, Russell NJ. The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans. J Gen Microbiol 1986; 132: 2421-2431.
20. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 226: 497-509.
21. Ghannoum MA, Janini G, Khamis L, Radwan SS. Dimorphism-associated variations in the lipid composition of Candida albicans. J Gen Microbiol 1986; 132: 2367-2375.
22. Ghannoum MA, Swairjo I, Soil DR. Variation in lipid and sterol contents in Candida albicans white and opaque phenotypes. J Med Vet Mycol 1990;28: 103-115.
23. Ghannoum MA, Moussa NM, Whittaker P, Swairjo I, AbuElteen K. Subinhibitory concentration of octenidine and pirtenidine: Influence on the lipid and sterol contents of Candida albicanse. Chemotherapy 1992; 38: 46-56.
24. Dawson RMC. Products of partial degradation of phospholipids. In: Zweig G, Sherma J, Mangold HK (eds.) Handbook of Chromatography. Lipids. Florida: CRC Press Inc, 1984: 545-554.
25. Chalvardjian A. Fatty acids of brown and yellow fat in rats. Biochem J 1964; 90: 518-521.
26. Fryberg M, Oehlschlager AC, Unrau AM. Sterol biosynthesis in antibiotic-resistant yeast:nystatin. Arch Biochem Biophys 1974; 160: 83-89.
27. Kates M. Techniques of Lipidology. Amsterdam: North-Holland Publishing Company, 1972: 393-469.
28. Vandenheuvel F, Court AS. Reference high-efficiency non-polar packed column for the gas-liquid chromatography of nanogram amounts of sterols. Part I: Retention time data. J Chromatog 1968; 38: 439-459.
29. Vandenheuvel F, Hinderks GJ, Nixon JC, Loyng WG. Precise ultramicro-determination of steroid hormones by combined TLC and GLC analysis. J Am Oil Chem Soc 1965; 42: 283.
30. Ghannoum MA, Abu-Elteen K, Ellabib M, Whittaker PA. Antimycotic effects of octenidine and pirtenidine. J Antimicrob Chemother 1990; 25: 237-245.
31. Hitchcock CA, Barrett-Bee KJ, Russell NJ. The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans. J Med Vet Mycol 1987; 25: 29-37.
32. Sundaram S, Sullivan PA, Shepherd MG. Changes in lipid composition during starvation and germ-tube formation in Candida albicans. Exp Mycol 1981; 5: 140-147.
33. Ratledge C, Evans Cl. Lipids and their metabolism. In: Rose AH, Harrison JS (eds.) The Yeast, Metabolism and Physiology of Yeasts. London: Academic Press, 1989.
34. Weete JD. Lipid Biochemistry of Fungi and Other Organisms. New York: Plenum Press, 1980.
35. Georgopapadakou NH, Dix BA, Smith SA, Freudenberger J, Funke PT. Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans. Antimicrob Agents Chemother 1987; 31: 46-51.
36. Morita T, Nozawa Y Effects of antifungal agents on ergosterol biosynthesis in Candida albicans and Trichophyton mentagrophytes: Differential inhibitory sites of naphthiomate and miconazole. J Invest Dermatol 1985; 85: 434-437.
37. Prasad R, Rose AH. Involvement of lipids in solute transport in yeast. Yeast 1986; 2: 205-220.
38. Ryder NS, Seidl G, Troke PF. Effect of antimycotic drag naftifine on growth of and sterol biosynthesis in Candida albicans. Antimicrob Agents Chemother 1984; 25: 483-487.
39. Fox CF. The structure of cell membrane. Scient Am 1972; 226: 31-38.
40. Singh M, Jayakumar A, Prasad R. The effect of altered ergosterol content on the transport of various amino acids in Candida albicans. Biochim Biophs Acta 1979; 555: 42-55.