A new practical index to predict capping occurring during the tableting process

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 44, Issue 3, 1997, Pages 323-326

  Sugimori, Ken Ichi ^a   Kawashima, Yoshiaki ^b  

^a JAPAN TOBACCO INC   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Capping; Capping index; Tablet

Indexed keywords

BUCETIN; CAFFEINE; ETHENZAMIDE; LACTOSE; STARCH;

ARTICLE; COMPRESSIVE STRENGTH; MATHEMATICAL ANALYSIS; STRESS STRAIN RELATIONSHIP; TABLET COMPRESSION; TABLET FORMULATION;

EID: 0031398693     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(97)00131-8     Document Type: Article

References (10)

1. P.J. Rue, P.M.R. Barkworth, P. Ridgway-Watt, P. Rough, D.C. Sharland, H. Seager, H. Fisher, Analysis of tablet fracture during tableting by acoustic emission techniques, Int. J. Pharm. Tech. Prod. Mfr. 1 (1979) 2-5.
2. G.E. Amidon, O.P. Smith, E.N. Hiestand, Rotary press utilizing a flexible die wall, J. Pharm. Sci. 70 (1981) 613-617.
3. L. Casahoursat, G. Lemagnen, D. Larrouture, The use of stress relaxation trials to characterize tablet capping, Drug Dev. Ind. Pharm. 14 (1988) 2179-2199.
4. P.J. Jarosz, E.L. Parrot, Factors influencing axial and radial tensile strengths of tablets, J. Pharm. Sci. 71 (1982) 607-614.
5. A.B. Bangudu, N. Pilpel, Effects of composition, moisture and stearic acid on the plasto-elasticity and tableting of paracetamol-microcrystalline cellulose mixtures, J. Pharm. Pharmacol. 37 (1985) 289-293.
6. W.E. Jetzer, Measurement of hardness and strength of tablets and their relation to compaction performance of powders, J. Pharm. Pharmacol. 38 (1986) 254-258.
7. K. Sugimori, S. Mori, Y. Kawashima, Introduction of a new index for the prediction of capping tendency of tablets, Chem. Pharm. Bull. 37 (1989) 458-462.
8. K. Sugimori, S. Mori, Y. Kawashima, Characterization of die wall pressure to predict capping of flat-or convex-faced drug tablets of various sizes, Powder Technol. 58 (1989) 259-264.
9. K. Sugimori, S. Mori, Y. Kawashima, The role of binders in the prevention of capping within a tablet, Chem. Pharm. Bull. 37 (1989) 1064-1067.
10. K. Sugimori, S. Mori, Y. Kawashima, Application of a newly defined capping index in evaluation of the compressibility of pharmaceutical powders, Adv. Powder Technol. 1 (1990) 25-37.