An in vitro-in vivo investigation of oral bioadhesive controlled release furosemide formulations

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 44, Issue 1, 1997, Pages 39-52

  Santus, Giancarlo ^a   Lazzarini, Caterina ^a   Bottoni, Giuseppe ^a   Sandefer, Erik P ^b   Page, Richard C ^b   Doll, Walter J ^b   Ryo, U Yun ^b   Digenis, George A ^b  

^a Recordati SpA   (Italy)

^b NONE

Author keywords

Scintigraphy; Bioadhesion; Controlled release formulation; Furosemide; Gastrointestinal transit; Neutron activation; Samarium 153

Indexed keywords

BIOPOLYMER; CARBOPOL 934; FUROSEMIDE; GELUCIRE; HYDROGENATED CASTOR OIL; HYDROXYPROPYLMETHYLCELLULOSE; LEUCINE; MAGNESIUM STEARATE; METHYLCELLULOSE; POVIDONE; SAMARIUM; TISSUE ADHESIVE;

ADHESION; ADULT; ANIMAL TISSUE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISSOLUTION; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG URINE LEVEL; GAMMA SCINTIGRAPHY; GASTROINTESTINAL TRANSIT; HUMAN; HUMAN EXPERIMENT; INTESTINE MUCOSA; MALE; NONHUMAN; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RANDOMIZED CONTROLLED TRIAL; SUSTAINED RELEASE FORMULATION;

EID: 0031398589     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(97)00100-8     Document Type: Conference Paper

References (21)

1. M.A. Longer, J.R. Robinson, Fundamental aspects of bioadhesion, Pharm. Int. 7 (1986) 114-117.
2. C.M. Lehr, J.A. Bouwstra, J.J. Tukker, H.E. Junginger, Intestinal transit of bioadhesive microspheres in vitro and in situ loop in the rat-A comparative study with copolymers and blends based on polyacrylic acid, J. Control. Release 13 (1990) 51-62.
3. D. Harris, J.T. Fell, H.L. Sharma, D.C. Taylor, GI transit of potential bioadhesive formulations in man: A scintigraphic study, J. Control. Release 12 (1990) 45-53.
4. V.S. Chitnis, V.S. Malshe, J.K. Lalla, Bioadhesive polymers - synthesis, evaluation and application in controlled release tablets, Drug Dev. Ind. Pharm. 17 (1991) 879-892.
5. M.R. Jimenez-Castellanos, Z. Hussein, C.T. Rhodes, Mucoadhesive drug delivery systems, Drug Dev. Ind. Pharm. 19 (1993) 143-194.
6. G.G. Santus, G. Bottoni, G. Sala, Pharmaceutical controlled release composition with bioadhesive properties, European Patent 516141, 1996.
7. O. Schuster, B. Hugemann, E.H. Graul, D. Loew, Absorptionslokalistion von furosemid durch Verwendung einer ferngesteuerten arzneimittelkapsel unter röntgen-und CT-kontrolle, in: E.H. Graul, D. Loew (Eds.), Pathophysiologie und Therapie des gestörten Natrium-und Wasserhaushaltes, Workshop Diuretika, Bad Nauheim, April 1984, pp. 128-137.
8. G.A. Digenis, E.P. Sandefer, Gamma scintigraphy and neutron activation techniques in the in vivo assessment of orally administered dosage forms, Crit. Rev. Ther. Drug Carrier Sys. 7 (1991) 309-345.
9. I.R. Wilding, A.J. Coupe, S.S. Davis, The role of gamma scintigraphy in oral drug delivery, Adv. Drug Deliv. Rev. 7 (1991) 87-117.
10. C.G. Wilson, N. Washington, Assessment of disintegration and dissolution of dosage forms in vivo using gamma scintigraphy, Drug Dev. Ind. Pharm. 14 (1988) 211-281.
11. S.S. Davis, J.G. Hardy, M.J. Taylor, D.R. Whalley, C.G. Wilson, The effect of food on the gastrointestinal transit of pellets and osmotic device (Osmet), Int. J. Pharm. 21 (1984) 331-340.
12. S.S. Davis, J.G. Hardy, J.W. Fara, Transit of pharmaceutical dosage forms through the small intestine, Gut 27 (1986) 886-892.
13. S. O'Reilly, C.G. Wilson, J.G. Hardy, The influence of food on the gastric emptying of multiparticulate dosage forms, Int. J. Pharm. 34 (1987) 213-216.
14. S.A. Sangekar, W.A. Vadino, I. Chaudry, A.F. Parr, R.M. Beihn, G.A. Digenis, Evaluation of the effect of food and specific gravity of tablets on gastric retention time, Int. J. Pharm. 35 (1987) 187-191.
15. A.F. Parr, M. Jay, G.A. Digenis, R.M. Beihn, Radiolabeling of intact tablets by neutron activation for in vivo scintigraphic studies, J. Pharm. Sci. 74 (1985) 590-591.
16. G.A. Digenis, A.F. Parr, M. Jay, Neutron activation methods for evaluation of pharmaceutical dosage forms, in: J.G. Hardy, S.S. Davis, C.G. Wilson (Eds.), Drug Delivery to the Gastrointestinal Tract, Ellis Horwood, Chichester, 1989, pp. 111-119.
17. G.A. Digenis, E.P. Sandefer, R.M. Beihn, A.F. Parr, Dual-Isotope imaging of neutron activated erbium-171 and samarium-153 and the in vivo evaluation of a dual-labeled bilayer tablet by gamma scintigraphy, Pharm. Res. 8 (1991) 1335-1340.
18. G. Sala, G. Bottoni, G.C. Santus, In vitro method to evaluate bioadhesion of microparticles, Proceedings of the 16th International Symposium on Controlled Release of Bioactive Materials Chicago, 1989.
19. D.A. Smith, E.T. Lin, L.Z. Benet, Absorption and disposition of furosemide in healthy volunteers, measured with a metabolitespecific assay, Drug Metab. Dispos. 8 (1980) 337-342.
20. L.L. Ponto, R.D. Schoenwald, Furosemide (Frusemide): a pharmacokinetic/pharmacodynamic review (Part I), Clin. Pharmacokinet. 18 (1990) 381-408.
21. J.X. Sun, B. Walter, E.P. Sandefer, R.C. Page, G.A. Digenis, U.Y. Ryo, A. Cipriano, W.M. Maniara, M.L. Powell, K. Chan, Explaining variable absorption of a hypolipidemic agent (CGP 43371) in healthy subjects by gamma scintigraphy and pharmacokinetics, J. Clin. Pharmacol. 36 (1996) 230-237.