Neurally mediated syncope and syncope due to autonomic failure: Differences and similarities

Journal of Clinical Neurophysiology

Volumn 14, Issue 3, 1997, Pages 183-196

  Kaufmann, Horacio ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Autonomic failure; Nitric oxide; Orthostatic hypotension; Syncope; Tilt table test; Treatment

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DESMOPRESSIN; DISOPYRAMIDE; ENDOTHELIN; ERYTHROPOIETIN; FLUDROCORTISONE; MIDODRINE; NORADRENALIN; PROPRANOLOL; RENIN; SEROTONIN UPTAKE INHIBITOR; SODIUM; THREO 3,4 DIHYDROXYPHENYLSERINE; VASOPRESSIN;

AUTONOMIC NERVOUS SYSTEM; BLOOD VOLUME; CAROTID SINUS PRESSORECEPTOR REFLEX; CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; EFFERENT NERVE; HEART ARRHYTHMIA; HEART PACING; HUMAN; HYPERTENSION; HYPOKALEMIA; HYPONATREMIA; ORTHOSTATIC HYPOTENSION; REVIEW; SALT INTAKE; SYNCOPE; TILTING; VASOCONSTRICTION;

AUTONOMIC NERVOUS SYSTEM DISEASES; CARDIAC PACING, ARTIFICIAL; CEREBROVASCULAR CIRCULATION; CIRCADIAN RHYTHM; DIAGNOSIS, DIFFERENTIAL; HUMANS; HYPOTENSION, ORTHOSTATIC; PERIPHERAL NERVOUS SYSTEM DISEASES; POSTURE; SYNCOPE; SYNCOPE, VASOVAGAL; TILT-TABLE TEST; VASOCONSTRICTION;

EID: 0031398402     PISSN: 07360258     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004691-199705000-00003     Document Type: Review

References (73)

1. Abboud F. Ventricular syncope. Is the heart a sensory organ? N Engl J Med 1989;320:390-2.
2. Almquist A, Goldenberg IF, Milstein S, et al. Provocation of bradycardia and hypotension by isoproterenol and upright posture in patients with unexplained syncope. N Engl J Med 1989; 320:346-51.
3. Ax AF. The physiological differentiation between fear and anger in humans. Psychosomat Med 1953;15:433-42.
4. Bachman D, Youmans W. Effects of posture on renal excretion of sodium and chloride in orthostatic hypotension. Circulation 1953;7:413-21.
5. Barcroft H, Edholm OG. On the vasodilatation in human skeletal muscle during post-haemorrhagic fainting. J Physiol 1945; 104:161-75.
6. Benditt DMD. Tilt table testing for assessing syncope. American Colledge of Cardiology 1996;28:263-75.
7. Biaggioni I, Robertson D, Krantz S. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin. Ann Intern Med 1994;121:181-6.
8. Blair DA, Glover WE, Greenfield ADM, Roddie IC. Excitation of cholinergic vasodilator nerves to human skeletal muscles during emotional stress. J Physiol 1959;148:633-47.
9. Bonamico L, Celnik P. Syncope and seizure-like activity secondary to acute herpes zoster infection of the trigeminal nerve. Cephalalgia 1995;15:241-2.
10. Bradbury S, Eggleston C. Postural hypotension: report of 3 cases. Am Heart J 1925;1:73-86.
11. Caro S, Bazil CW, Kaufmann H. Abnormal motor activity in autonomic failure: distinction from seizures [abstract]. Neurology 1996;4:A224.
12. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. The Consensus Committee of the American Autonomic Society and the American Academy of Neurology. Neurology 1996;46(5):1470.
13. Costa F, Biaggioni I. Microneurographic evidence of sudden sympathetic withdrawal in carotid sinus syncope; treatment with ergotamine. Chest 1994;106:617-20.
14. Dangovian MI, Jarandilla R, Frumin H. Prolonged asystole during head-up tilt table testing after beta blockade. Pacing Clin Electrophysiol 1992;15:14-6.
15. Dehn T, Morley C, Sutton R. A scientific evaluation of the carotid sinus syndrome. Cardiovasc Res 1984;18:746-51.
16. Dickinson CJ. Fainting precipitated by collapse-firing of venous baroreceptors. Lancet 1993;342(8877):970-2.
17. Dietz NM, Rivera JM, Eggener SE, et al. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol Lond 1994;480:361-8.
18. Ekman P, Levenson RW, Friesen WV. Autonomic nervous system activity distinguishes among emotions. Science 1983;221: 1208-10.
19. El-Bedawi K, Hainsworth R. Combined head-up tilt and lower body suction: a test of orthostatic tolerance. Clin Autonom Res 1994;4:41-7.
20. El-Bedawi K, Wahbha MA, Hainsworth R. Cardiac pacing does not improve orthostatic tolerance in patients with vasovagal syncope. Clin Autonom Res 1994;4(5):233-7.
21. El-Sayed H, Hainsworth R. Salt supplement increases plasma volume and orthostatic tolerance in patients with unexplained syncope. Heart 1996;75:134-40.
22. Fell D, Derbyshire DR, Maile CJ, et al. Measurement of plasma catecholamine concentrations: an assessment of anxiety. Br J Anaesth 1985;57:770-4.
23. Fitzpatrick A, Bannder N, Cheng A, et al. Vasovagal reactions may occur after orthotopic heart transplantation. J Am Coll Cardiol 1993;21:1132-7.
24. Frank J, Ropper A, Zuniga G. Vasodepressor carotid sinus syncope associated with a neck mass. Neurology 1992;42:1194-7.
25. Freeman R, Landsberg L. The treatment of orthostatic hypotension with dihydroxiphenilserine. Clin Neuropharmacol 1991;14(4): 296-304.
26. Freeman R, Young J, Landsberg L, Lipsitz L. The treatment of postprandial hypotension in autonomic failure with 3,4-DL-threodihydroxylphenylserine. Neurology 1996;47:1414-20.
27. Gastaut H, Fischer-Williams M. Electroencephalographic study of syncope: its differentiation from epilepsy. Lancet 1957;2:1018-25.
28. Glover W, Greenfield A, Shanks R. The contribution made by adrenaline to the vasodilation in the human forearm during emotional stress. J Physiol (Lond) 1962;164:422-9.
29. Goldstein D. Stress response patterns. In: Stress, catecholamines, and cardiovascular disease. New York: Oxford University Press, 1995:287-328.
30. Gordon RD, Kuchel O, Liddle GW, Island DP. Role of the sympathetic nervous system in regulating renin and aldosterone production in man. J Clin Invest 1967;46:599-605.
31. Grubb B, Wolfe D, Samoil D, et al. Usefulness of fluoxetine hydrochloride for prevention of resistant upright tilt induced syncope. Pace Pacing Clin Electrophysiol 1993;16:458-64.
32. Hickler R. Successful treatment of orthostatic hypotension with 9-alpha fluorohydrocortisone. N Engl J Med 1959;261:788-91.
33. Hoeldtke RD, Streeten DH. Treatment of orthostatic hypotension with erythropoietin. N Engl J Med 1993;329:611-5.
34. Jankovic J, Gilden JL, Hiner BC, et al. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med 1993;95:38-48.
35. Kapoor W, Peterson J, Karpf M. Micturition syncope. A reappraisal. JAMA 1985;253:796-8.
36. Kapoor WN, Brant N. Evaluation of syncope by upright tilt testing with isoproterenol. A nonspecific test. Ann Intern Med 1992; 116:358-63.
37. Kaufmann H. Head up tilt, lower body negative pressure, pacemakers and vasovagal syncope. Clin Autonom Res 1994;4:231-2.
38. Kaufmann H. Neurally mediated syncope: pathogenesis, diagnosis, and treatment. Neurology 1995;45:S12-8.
39. Kaufmann H. Could treatment with DOPs do for autonomic failure what DOPA did for Parkinson's Disease. Neurology 1996; 47:1370-1.
40. Kaufmann H, Berman J, Oribe E, Oliver J. Possible increase in the synthesis of endothelial derived relaxing factor (EDRF) during vasovagal syncope [abstract]. Clin Autonomic Res 1993;3:69.
41. Kaufmann H, Brannan T, Krakoff L, Yahr MD, Mandeli J. Treatment of orthostatic hypotension due to autonomic failure with a peripheral alpha-adrenergic agonist (midodrine). Neurology 1988; 38:951-6.
42. Kaufmann H, Oribe E, Miller M, Knott P, Wiltshire-Clement M, Yahr MD. Hypotension-induced vasopressin release distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Neurology 1992;42:590-3.
43. Kaufmann H, Oribe E, Oliver JA. Plasma endothelin during upright tilt: relevance for orthostatic hypotension? Lancet 1991a; 338:1542-5.
44. Kaufmann H, Oribe E, Pierotti AR, Roberts JL, Yahr MD. Atrial natriuretic factor in human autonomic failure. Neurology 1990;40:1115-9.
45. Kaufmann H, Oribe E, Yahr MD. Differential effect of L-threo-3,4-dihydroxyphenylserine in pure autonomic failure and multiple system atrophy with autonomic failure. J Neural Transm Park Dis Dement Sect 1991b;3:143-8.
46. Koizumi K, Kollai M. Control of reciprocal and non-reciprocal action of vagal and sympathetic efferents: study of centrally induced reactions. J Auton Nerv Syst 1981;3:483-501.
47. LeDoux JE. Emotion and the amygdala. In: Aggleton JP, ed. The amygdala: neurbiological aspects of emotion, memory, and mental dysfunction. New York: Wiley-Liss, 1992:339-51.
48. Lewis T. Lecture on vasovagal syncope and the carotid sinus mechanism. Br Med J 1932;1:873-6.
49. Mark AL. The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart. J Am Coll Cardiol 1983;1(1):90-102.
50. Mathias C, Armstrong E, Browse N, Chaudhuri K, Enevoldson P, Russell R. Value of non-invasive continuous blood pressure monitoring in the detection of carotid sinus hypersensitivity. Clin Auton Res 1991;1:157-9.
51. Mathias C, Fosbraey P, da-Costa D, Thornley A, Bannister R. The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure. Br Med J Clin Res Ed 1986;293:353-4.
52. Morillo C, Leitch J, Yee R, Klein G. A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. J Am Coll Cardiol. 1993;22:1843-8.
53. O'Marcaigh A, MacLellan-Tobert S, Porter C. Tilt-table testing and oral metoprolol therapy in young patients with unexplained syncope. Pediatrics 1994;93:278-83.
54. Oberg B, Thoren P. Increased activity in vagal cardiac afferents correlated to the appearance of reflex bradycardia during severe hemorrhage in cats. Acta Physiol Scand 1970;80:22a-3a.
55. Oberg B, Thoren P. Increased activity in left ventricular receptors during hemorrhage or occlusion of caval veins in the cat. A possible cause of the vaso-vagal reaction. Acta Physiol Scand 1972a;85:164-73.
56. Oberg B, Thoren P. Studies on left ventricular receptors, signalling in non-medullated vagal afferents. Acta Physiol Scand 1972b; 85:145-63.
57. Oribe E, Kaufmann H, Winters S, Gomes J. Fludrocortisone versus beta-adrenergic blockers in the treatment of vasovagal syncope. Neurology 1992;42(Suppl 3):213.
58. Oribe E, Perera R, Caro S, Winters S, Gomes A, Kaufmann H. Syncope: the diagnostic value of head-up tilt testing. PACE Pacing Clin Electrophysiol 1997;20(4):874-9.
59. Perera R, Isola L, Kaufmann H. Erythropoietin improves orthostatic hypotension in primary autonomic failure [abstract]. Neurology 1994;44:A363.
60. Petersen ME, Chamberlain-Webber R, Fitzpatrick AP, Ingram A, Williams T, Sutton R. Permanent pacing for cardioinhibitory malignant vasovagal syndrome. Br Heart J 1994;71:274-81.
61. Raviele A, Gasparine G, Di Pede F, et al. Nitroglycerin infusion during upright tilt: a new test for the diagnosis of vasovagal syncope. Ann Heart J 1994;127:103-111.
62. Robertson D, Goldberg MR, Onrot J, et al. Isolated failure of autonomic noradrenergic neurotransmission. Evidence for impaired beta-hydroxylation of dopamine. N Engl J Med 1986;314: 1494-7.
63. Robertson D, Wade D, Robertson R. Post-prandial alterations in cardiovascular hemodynamics in autonomic dysfunction states. Am J Cardiol 1981;48:1048-52.
64. Sharpey-Schafer EP, Hayter CJ, Barlow ED. Mechanism of acute hypotension from fear or nausea. Br Med J 1958;2:878-80.
65. Shear L. Orthostatic hypotension. Treatment with sodium chloride and sodium retaining steroid hormones. Arch Intern Med 1968;122:467-71.
66. Shy GM, Drager GA. A neurological syndrome associated with orthostatic hypotension. Arch Neurol 1960;2:511-27.
67. Ushiyama K, Ogawa T, Ishii M, Ajisaka R, Sugishita Y, Ito I. Physiologic neuroendocrine arousal by mental arithmetic stress test in healthy subjects. Am J Cardiol 1991;67:101-3.
68. van Lieshout JJ, Wieling W, Karemaker JM, Eckberg DL. The vasovagal response. Clin Sci Colch 1991;81:575-86.
69. Wallin B, Westerberg C, Sundloff G. Syncope induced by glossopharyngeal neuralgia: sympathetic outflow to muscle. Neurology 1984;34:522-24.
70. Wilcox C, Aminoff M, Slater J. Sodium homeostasis in patients with autonomic failure. Clin Sci Mol Med 1977;53:321-8.
71. Wilcox C, Puritz R, Lightman S, Bannister R, Aminoff M. Plasma volume regulation in patients with progressive autonomic failure during changes in salt intake and posture. J Lab Clin Med 1984;104:331-9.
72. Zambrasky E, DiBona G, Kaloyanides G. Specificity of neural effect on renal tubular sodium reabsorption. Proc Soc Exp Biol Med 1976;151:543-6.
73. Ziegler MG, Lake CR, Kopin IJ. The sympathetic-nervous-system defect in primary orthostatic hypotension. N Engl J Med 1977;296:293-7.