Early genetic and cellular responses in the smooth muscle layer of obstructed ureters in a rat model of obstructive uropathy

British Journal of Urology

Volumn 80, Issue 4, 1997, Pages 548-553

  Chuang, Y H ^a,b   Chuang, W L ^a   Liu, K M ^a   Chen, S S ^a,b   Huang, C H ^a  

^a Department of Neurology ^*  (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

c Jun; c Myc; cFos; Ki 67; Obstructive uropathy; Rat

Indexed keywords

GENE PRODUCT; KI 67 ANTIGEN; MYC PROTEIN; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXPERIMENTAL LIGATION; FEMALE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MICROSCOPY; MUSCLE CELL; MUSCLE HYPERTROPHY; NONHUMAN; OBSTRUCTIVE UROPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROUGH ENDOPLASMIC RETICULUM; SMOOTH MUSCLE; TIME; URETER OBSTRUCTION;

ANIMALS; ENDOPLASMIC RETICULUM, ROUGH; FEMALE; IMMUNOHISTOCHEMISTRY; LIGATION; MUSCLE, SMOOTH; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, SPRAGUE-DAWLEY; URETERAL OBSTRUCTION;

EID: 0031396857     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Gillenwater JY. The pathophysiology of urinary tract obstruction. In Walsh PC, Retik AB, Stamey TA, Vaughan ED eds, Campbell's Urology, Vol I. Philadelphia: WB Saunders, 1992: 499-532
2. Harada T, Issa MM, Kiqure T. Ureteral compliance and histology in partial obstruction in a canine model. J Urol 1992; 148: 1274-8
3. Chuang YH, Chuang WL, Huang SP, Liu KM, Huang CH. The temporal relationship between the severity of hydroureter and the dynamic changes of obstructed ureters in a rat model. Br J Urol 1995; 76: 303-10
4. Cussen LJ, Tymms A. Hyperplasia of ureteral muscle in response to acute obstruction of the ureter: a quantitative study. Invest Urol 1972; 9: 504-8
5. Angel P, Karin M. The role of jun, fos and AP-1 complex in cell- proliferation and transformation. Biochim Biophys Acta 1991; 1072: 129-57
6. Karin M, Smeal T. Control of transcription factors by signal transduction pathways: the beginning of the end. TIBS 1992; 17: 418-22
7. Kato GJ, Dang CV. Function of c-myc oncoprotein. FASEB J 1992; 6: 3065-72
8. Yu CCW, Filipe MI. Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications. Histochemical J 1993; 25: 843-53
9. Hsu SM, Raine L. The use of avidin-biotin-peroxidase complex (ABC) in diagnostic and research pathology. In Delellis RA ed., Advances in Immunohistochemistry. Chicago: Year Book Medical, 1984: 31-42
10. Bozzola JJ, Russell LD. Electron Microscopy Principles and Techniques for Biologists. Boston: Jones and Bartlett, 1992
11. Komuro I, Kurabayashi M, Takaku F, Yazaki Y. Expression of cellular oncogene in the myocardium during the developmental stage and pressure- overloaded hypertrophy of the rat heart. Circ Res 1988; 62: 1075-9
12. Izumo S, Nadal-Ginard B, Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure load. Proc Natl Acad Sci USA 1988; 85: 339-43
13. Komuro I, Katch Y, Kaida T et al. Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. J Biol Chem 1991; 266: 1265-8
14. Yazaki Y, Komuro I, Yamazaki T et al. Role of protein kinase system in the signal transduction of stretch mediated protooncogene expression and hypertrophy of cardiac myocytes. Mol Cell Biol 1993; 119: 11-6
15. Karin OMA, Seki N, Mostwin JL. Detrusor hyperplasia and expression of 'immediate early' genes with onset of abnormal urodynamic parameters. Am J Physiol 1992; 263: R1284-90
16. Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD. Molecular Biology of the Cell. New York: Garland. 1994
17. Starksen NF, Simpson PC, Bishopric N et al. Cardiac myocyte hypertrophy is associated with c-myc protooncogene expression. Proc Natl Acad Sci USA 1986; 83: 8348-50
18. Chen MW, Krasnapolsky L, Levin RM, Buttyan R. An early molecular response induced by acute overdistension of the rabbit urinary bladder. Mol Cell Biochem 1994; 132: 39-44
19. Buttyan R, Jacobs B, Potter L, Levin RM. Alterations in the genetic activity of the rabbit bladder demonstrates the onset of a tissue remodeling process initiated by partial urethral obstruction. J Urol 1991; 145: 387A
20. Miano JM, Tota RR, Vlasic N, Danishefsky KJ, Stemerman MB. Early proto- oncogene expression in rat aortic smooth muscle cells following endothelial removal. Am J Pathol 1990; 137: 761-5
21. Whitelaw PF, Hesketh JE. Expression of c-myc and c-fos in rat skeletal muscle: evidence for increased levels of c-myc mRNA during hypertrophy. Biochem J 1992; 281: 143-7
22. Brent L, Stephens. The response of smooth muscle cells in the rabbit urinary bladder to outflow obstruction. Invest Urol 1975; 12: 494-502
23. Pettaway CA, Murphree S, McConnell JD. The response of detrusor smooth muscle nucleus to obstruction. J Urol 1990; 143: 367A
24. 3H-thymidine uptake: a biochemical and radioautographic study. J Urol 1992; 148: 158-62
25. Buoro S, Ferrarese P, Chiavegato A et al. Myofibroblast-derived smooth muscle cells during remodelling of rabbit urinary bladder wall induced by partial outflow obstruction. Lab Invest 1993; 69: 589-602