Characterization of neuronal cell death induced by complement activation

Brain Research Protocols

Volumn 1, Issue 2, 1997, Pages 186-194

  Shen, Yong ^a   Halperin, Jose A ^b   Benzaquen, Laura ^b   Lee, Chi Ming ^a  

^a Pharmaceutical Products Division   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

CD59 complement inhibitor; Cell death; Complement; Membrane attack complex; Neurodegeneration

Indexed keywords

CD59 ANTIGEN; COMPLEMENT; COMPLEMENT MEMBRANE ATTACK COMPLEX; LACTATE DEHYDROGENASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SWELLING; COMPLEMENT ACTIVATION; CYTOLYSIS; ENZYME RELEASE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIGENS, CD59; BLOOD PHYSIOLOGY; CELL DEATH; COMPLEMENT ACTIVATION; COMPLEMENT C3B; COMPLEMENT MEMBRANE ATTACK COMPLEX; DRUG COMBINATIONS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; L-LACTATE DEHYDROGENASE; NEURONS; PC12 CELLS; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPASE C; POLYMERASE CHAIN REACTION; RATS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0031396818     PISSN: 1385299X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1385-299X(96)00026-8     Document Type: Article

References (25)

1. Carney, D.F., Hammer, C.H. and Shin, M.L., Elimination of terminal complement complexes in the plasma membrane of nucleated cells: influence of extracellular calcium and association with cellular calcium, J. Immunol., 137 (1986) 263-273.
2. Volanakis, J.E. and Fearon, D.T., The molecular biology of the complement system. In: D.J. McCarty and W.J. Koopman (Eds.), Arthritis and Allied Conditions - a Textbook of Rheumatology, Lea and Febiger, Philadelphia, PA, 1984, pp. 445-467.
3. 2+ on the lytic process, J. Immunol., 138 (1987) 1530-1536.
4. Muller-Eberhard, H.J., Zalman, L.S., Chiu, F.J., Jung, G. and Martin, D.E., Molecular mechanisms of cytotoxicity: comparison of complement and killer lymphocytes, J. Rheumatol., 14 (1987) 28-34.
5. Hamilton, K.K., Zhao, J., Rollins, S., Stewart, B.H. and Sims, P.J., Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59, Blood, 76 (1990) 2572-2577.
6. Braak, H., Braak, E. and Bohl J., Staging of Alzheimer-related cortical destruction, Eur. Neurol., 33 (1993) 403-408.
7. Brachova, L., Lue, L.-F., Schultz, J., El Rashidy, T. and Rogers, J., Association cortex, cerebellum, and serum concentrations of C1q and factor B in Alzheimer's disease, Mol. Brain Res., 18 (1993) 329-334.
8. Brimijoin, S., Moser, V., Hammond, P., Oka, N. and Lennon, V.A., Death of intermediolateral spinal cord neurons follows selective complement-mediated destruction of peripheral preganglionic sympathetic terminals by acetylcholinesterase antibodies, Neuroscience, 54 (1993) 201-223.
9. Duguid, J.R., Bohmont, C.W., Liu, N. and Tourtellotte, W.W., Changes in brain gene expression shared by scrapie and Alzheimer disease, Proc. Natl. Acad. Sci. USA, 86 (1989) 7260-7265.
10. Eikelenboom, P., Rozemuller, J.M., Kraal, G., Stam, F.C., McBride, P.A., Bruce, M.E. and Fraser, H., Cerebral amyloid plaques in Alzheimer's disease but not in scrapie-affected mice are closely associated with a local inflammatory process, Virchows Arch. (B), 60 (1989) 329-336.
11. McGeer, P.L., Akiyama, H., Itagaki, S. and McGeer, E.G., Immune system response in Alzheimer's disease, Can. J. Neurol. Sci., 107 (1989) 341-346.
12. Rogers, J., Cooper, N.R., Webster, S., Schultz, J., McGeer, P., Styren, S.D., Civin, W.H., Brachova, L., Bradt, B., Ward, P. and Lieberburg, I., Complement activation by β-amyloid in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 89 (1992) 10016-10020.
13. Rogers, J., Schultz, S., Brachova, L., Lue, L.-F. Webster, S., Bradt, B., Cooper, N.R. and Moss, D.E., Complement activation and β-amyloid-mediated neurotoxicity in Alzheimer's disease, Res. Immunol., 143 (1992) 624-630.
14. Shen, Y., Halperin, J. and Lee, C.-M., Neurotoxicity of complement activation is regulated by homlogous restriction, Brain Res., 671 (1995) 282-292.
15. Halperin, J.A., Tatatuska, A., Rynkiewicz, M. and Nicholson-Weller, A., Transient changes in erythrocyte membrane permeability are induced by sublytic amounts of the complement membrane complex (C5b-9), Blood, 81 (1993) 200-205.
16. McGeer, P.L., Walker, D.G., Akiyama, H., Kawamata, A.L., Guan, A.L., Parker, C.J., Okada, N. and McGeer, E.G., Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain, Brain Res., 544 (1991) 315-319.
17. Holguin, M.H., Frederick, L.R., Bernshaw, N.J., Wilcox, L.A. and Parker, C.J., Isolation and characterization of a membrane protein from normal human erythrocytes that inhibits reactive lysis of the erythrocytes of paroxysmal nocturnal hemoglobinuria, J. Clin. Invest., 84 (1989) 7-14.
18. Meri, S., Morgan, B.P., Davies, A., Danials, R.H., Olavesen, M.G., Waldmann, H. and Lachmann, P.J., Human protein (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers, Immunology, 72 (1990) 1-4.
19. Gordon, D.L., Sadlon, T., Hefford, C. and Adrian, D., Expression of CD59, a regulator of the membrane attack complex of complement, on human astrocytes, Mol. Brain Res., 18 (1993) 335-338.
20. Whitehouse, P.J., Price, D.L., Struble, R.G., Clark, A.W., Coyle, J.T. and DeLong, M.R., Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain, Science, 215 (1982) 1237-1239.
21. 2+ in complement membrane attack, Cell Calcium, 178 (1986) 115-139.
22. + efflux limits complement-mediated lysis of human erythrocytes, J. Clin. Invest., 82 (1988) 594-600.
23. 5b-9, J. Immunol., 147 (1991) 212-217.
24. 5b-9, Immunopharmacology, 24 (1992) 107-117.
25. Wing, M.G., Zajicek, J., Seilly, D.J., Compston, D.A.S. and Lachmann, P.J., Oligodendrocytes lack glycolipid anchored proteins which protect them against complement lysis. Restoration of resistance to lysis by incorporation of CD59, Immunology, 76 (1992) 140-145.