Enhanced thrombogenicity and altered hemodynamics in the cerebral microvasculature of stroke-prone spontaneously hypertensive rats

Pathophysiology of Haemostasis and Thrombosis

Volumn 27, Issue 5, 1997, Pages 237-245

  Noguchi, Takanori ^a   Sasaki, Yasuto ^a   Seki, Junji ^b   Giddings, John C ^c   Yamamoto, Junichiro ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

He Ne laser; Nitric oxide; Pial vessels; SHRSP; Thrombus; Wall shear rate

Indexed keywords

NITRIC OXIDE;

ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL OCCLUSION; BRAIN BLOOD VESSEL; COMPARATIVE STUDY; ERYTHROCYTE; HEMODYNAMIC MONITORING; HYPERTENSION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; STROKE; THROMBOCYTE AGGREGATION; THROMBOSIS;

ANIMALS; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; HEMODYNAMIC PROCESSES; MALE; PLATELET AGGREGATION; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 0031395438     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217462     Document Type: Article

References (32)

1. Okamoto K, Yamori Y, Nagaoka K: Establishment of the stroke prone spontaneously hypertensive rats (SHR). Cire Res 1974:34/35(suppl 1); 143-153.
2. Yamori Y: The stroke-prone spontaneously hypertensive rats: Contribution to risk factor analysis and prevention of hypertensive disease; in de Jong W (ed): Experimental and Genetic Models of Hypertension. Amsterdam. Elsevier, 1984, pp 240-255.
3. Yamori Y: Overview: Studies on spontaneous hypertension-development from animal models toward man. Clin Exp Hypertens 1991;A13: 631-644.
4. Ogata J, Fujishima M, Tamaki K, Nakatomi Y, Ishituka T, Omae T: Vascular changes underlying cerebral lesions in stroke-prone spontaneously hypertensive rats. A serial section study. Acta Neuropathol (Berl) 1981;54:183-188.
5. Fredriksson K, Nordborg C, Kalimo H, Olsson Y, Johansson BB: Cerebral microangiopathy in stroke-prone spontaneously hypertensive rats. An immunohistochemical and ultrastructural study. Acta Neuropathol (Berl) 1988;75:241-252.
6. 2* in aggregation, secretion and protein phosphorylation of per-meabilized platelets from stroke-prone spontaneously hypertensive rats. Thromb Res 1992;67:655-663.
7. Klee A, Vater S, Schmid-Schonbein GW, Seiffge D: Evidence from comparative investigations that impaired platelet activation is not specific for stroke-prone spontaneously hypertensive rats. Stroke 1993;24: 1528-1533.
8. Oyama T, Sasaki Y, Okita N, Gid-dings JC, Seki J, Yamamoto J Cerebral prothrombotic state in spontaneously hypertensive rats of different breeds. Haemostasis 1996;26: 79-84.
9. Yamori Y, Nagaoka A. Okamoto K: Importance of genetic factors in hypertensive cerebrovascular lesions: An evidence obtained by successive selective breeding of stroke-prone and-resistant SHR. Jpn Circ J 1974; 38:1095-1100.
10. Nabika T, Nara Y, Ikeda K, Endo J. Yamori Y: Genetic heterogeneity of the spontaneously hypertensive rats between the different sources. Hypertension 1991;18:12-16.
11. Rees D, Ben-Ishay D. Moncada S: Nitric oxide and the regulation of blood pressure in the hypertension-prone and hypertension-resistant Sabra rat. Hypertension 1996;28: 367-371.
12. Forte P, Copland M. Smith LM. Milne E, Sutherland J, Benjamine N: Basal nitric oxide synthesis in essential hypertension. Lancet 1997; 349:837-842.
13. Tagami M, Ikeda K, Nara Y. Fujino H, Kubota A, Numano F, Yamori Y: Detailed examination of vascular lesions triggered by an inhibitor of endothelium-derived relaxing factor. Lab Invest 1995;72:174-182.
14. Sato M, Ohshima N: Effects of wall shear rate on thrombogenesis in mi-crovcssels of the rat mesentery. Circ Res 1990;66:941-949.
15. Sessa WC, Kirkwood P, Seyedi N, Wang J, Hintze TH: Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 1994:74: 349-353.
16. Hecker M, Miilsch A, Bassengc E, Busse R: Vasoconstriction and increased flow: Two principal mechanisms of shear stress-dependent endothelial autacoid release. Am J Physiol 1993;265:H828-H833.
17. Moncada S, Palmer RMJ. Higgs EA: Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-142.
18. De Graaf JC, Banga JD, Moncada S, Palmer RMJ. de Groot PG, Sixma JJ: Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation 1992; 85:2284-2290.
19. Murata S, Rosenblum WI, Shimizu T. Nelson GH: Delayed platelet ad-hesion/aggregation at sites of endothelial injury in mouse cerebral arterioles after transient elevations of blood pressure and shear. Stroke 1995;26:650-654.
20. Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dal-kara T: L-argininc infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke 1994;25: 429-435.
21. Zhang F, Iadecola C: Nitroprusside improves blood flow and reduces brain damage after focal ischemia. Neuroreport 1993;4:559-562.
22. Morii S, Ngai AC. Winn HR: Reactivity of rat pial arterioles and venules to adenosine and carbon dioxide: With detailed description of the closed cranial window technique in rat. J Cereb Blood Flow Metab 1986;6:34-41.
23. Sasaki Y, Morii S, Yamashita T, Yamamoto J: Antithrombotic effect of argatroban on the piai vessels of the rat: A study with He-Ne laser-induced thrombosis formation. Haemostasis 1993;23:104-111.
24. Sasaki Y, Seki J, Giddings JC, Yamamoto J: Effects of NO-donors on thrombus formation and microcirculation in cerebral vessels of the rat. Thromb Haemost 1996;76:111-117.
25. Seki J, Sasaki Y, Oyama T, Yamamoto J: Fiber-optic laser Doppler anemometer microscope applied to the cerebral microcirculation in rats. Biorheology 1996;33:461-468.
26. Turitto VT, Baumgartner HR: Initial deposition of platelets and fibrin on vascular surfaces in flowing blood; in Colman RW, Hirsh J, Mardcr VJ, Salzman EW (eds): Hemostasis and Thrombosis. Basic Principles and Clinical Practice, ed 3. Philadelphia, Lippincott, 1994, pp 805-822.
27. Onda T, Mashiko S, Hamano M, Tomita I, Tomita T: Enhancement of cndothelium-depcndcm relaxation in the aorta from stroke-prone spontaneously hypertensive rats at developmental stages of hypertension. Clin Exp Pharmacol Physiol 1994;21:857-863.
28. Povlishock JT, Roscnblum WI: Injury of brain microvcsscls with a helium-neon laser and Evans blue can elicit local platelet aggregation without endothelial denudation. Acta Pathol Lab Med 1987:111:415-421.
29. Yamori Y, Ohta K, Horie R, Nara Y, Ooshima A: Chemical analysis of vascular collagen in stroke-prone SHR. Jpn Heart J 1979;20:264-266.
30. Yamori Y, Ohta K, Horie R, Ohtaka M, Nara Y, Ooshima A: A new model for cerebral thrombosis and its pathogenesis. Jpn Heart J 1979;20: 343-345.
31. Sciffge D: Hemorheological aspects of cerebrovascular diseases; in Mut-schuler E, Winterfeld E (eds): Trends in Medical Chemistry. Weinheim, VCH Publishers, 1987, pp 291-310.
32. ryler J, Chleide E, Liégeois JF, Carreer F: Nitric oxide: A new messenger in the brain. Neurosci Biobe-havRcv 1993;17:373-384.