Neurally mediated syncope: A review of cardiac and arterial receptors

Journal of Clinical Neurophysiology

Volumn 14, Issue 3, 1997, Pages 170-182

  Grimm, David R ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Arterial baroreceptors; Atrial and ventricular receptors; Neurocardiogenic syncope; Sympathetic and parasympathetic nervous system

Indexed keywords

HEART RECEPTOR;

ADRENERGIC SYSTEM; AORTA PRESSORECEPTOR; BLOOD VOLUME; BRADYCARDIA; CAROTID SINUS PRESSORECEPTOR; CHOLINERGIC SYSTEM; HEART ATRIUM RECEPTOR; MECHANORECEPTOR; NERVE FIBER C; ORTHOSTATIC HYPOTENSION; PRESSORECEPTOR REFLEX; REVIEW; SENSORY NERVE; SYNCOPE; VAGUS NERVE;

AUTONOMIC NERVOUS SYSTEM; BLOOD VOLUME; HEART CONDUCTION SYSTEM; HEMODYNAMIC PROCESSES; HOMEOSTASIS; HUMANS; HYPOTENSION, ORTHOSTATIC; MECHANORECEPTORS; POSTURE; PRESSORECEPTORS; RECEPTORS, NEUROPEPTIDE; SYNCOPE;

EID: 0031394927     PISSN: 07360258     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004691-199705000-00002     Document Type: Review

References (142)

1. Abboud FM. Integration of reflex responses in the control of blood pressure and vascular resistance. Am J Cardiol 1979;44:903-11.
2. Abboud FM. Ventricular syncope: is the heart a sensory organ? N Engl J Med 1989;320:390-2.
3. Abi-Samra F, Maloney JD, Fouad-Tarazi F, et al. The usefulness of head-up tilt testing and hemodynamic investigations in the workup of syncope of unknown origin. PACE 1988;11:1202-14.
4. Anderson CH, McCally M, Farrell GL. The effects of atrial stretch on aldosterone secretion. Endocrinology 1959;63:202-7.
5. Arndt JO, Brambring P, Hindorf K, Rohnelt M. The afferent discharge of atrial mechanoreceptors in the cat during sinusoidal stretch of atrial strips in situ. J Physiol 1974;240:33-52.
6. Arndt JO, Brambring P, Hindorf K, et al. The afferent impulse traffic from atrial A-type receptors in cats. Pflugers Arch 1971;326: 300-15.
7. Bainbridge FA. The influence of venous filling upon the rate of the heart. J Physiol 1915;50:65-84.
8. Baker DG, Coleridge HM, Coleridge JG. Vagal afferent C fibers from the ventricles. In: Hainsworth R, Kidd C, Linden RJ, eds. Cardiac receptors, Cambridge, U.K.: Cambridge University Press, 1979:117-37.
9. Banzett RB, Coleridge HM, Coleridge JCG, Kidd C. Multiterminal afferent fibers from the thoracic viscera in sympathetic rami communicantes of cats and dogs [Abstract]. J Physiol 1976;254:57.
10. Bennett KL, Linden RJ, Mary DA. The atrial receptors responsible for the decrease in plasma vasopressin caused by distension of the left atrium in the dog. Q J Exp Physiol 1984;69:73-81.
11. Bennett KL, Linden RJ, Mary DA. The effect of stimulation of atrial receptors on the plasma concentration of vasopressin. Q J Exp Physiol 1983;68:579-89.
12. Bennett KL, Linden RJ. Effects of the cessation of an infusion of vasopressin in acute hypophysectomized anaesthetized dogs. Q J Exp Physiol 1989;74:841-9.
13. Bevegard BS, Shepherd JT. Reaction in man of resistance and capacity vessels in forearm and hand to leg exercise. J Appl Physiol 1966;21:123-32.
14. Bezold A, Hirt L. Über die physiologischen Wirkungen des essigsauren Veratrins. Unters Physiol Lab Würzburg 1867; 1:73-156.
15. Borst C, Wieling W, van Brederode JFM, Hond A, de Rijk LG, Dunning AJ. Mechanisms of initial heart rate response to postural change. Am J Physiol 1982;243:H676-81.
16. Brennan LA, Malvin RL, Jochim KE, Roberts DE. Influence of right and left atrial receptors on plasma concentrations of ADH and renin. Am J Physiol 1971;221:273-8.
17. Bronk DW, Stella G. Afferent impulses in the carotid sinus nerve: the relation of the discharge from single end organs to arterial blood pressure. J Cell Comp Physiol 1932;1:113-30.
18. Brosnihan KB, Bravo EL. Graded reduction of atrial pressure and renin release. Am J Physiol 1978;235:H175-81.
19. Brown AM. Receptors under pressure: an update on baroreceptors. Circ Res 1980;46:1-10.
20. Brown AM, Malliani A. Spinal sympathetic reflexes initiated by coronary receptors. J Physiol 1971;112:685-705.
21. Brown AM. Excitation of afferent cardiac sympathetic nerve fibers during myocardial ischemia. J Physiol 1967;190:34-53.
22. Brown AM. Mechanoreceptors in or near the coronary arteries. J Physiol 1965;177:203-14.
23. Carswell F, Hainsworth R, Ledsome JR. The effects of left atrial distension upon urine flow from the isolated perfused kidney. Q J Exp Physiol 1970;55:173-82.
24. Casadei B, Meyer TE, Coats AJ, Conway J, Sleight P. Baroreflex control of stroke volume in man: an effect mediated by the vagus. J Physiol 1992;448:539-50.
25. Clozel JP, Pisarri TE, Coleridge HM, Coleridge JC. Reflex coronary vasodilatation evoked by chemical stimulation of cardiac afferent vagal C fibers in dogs. J Physiol 1990;428:215-32.
26. Coleridge HM, Coleridge JCG. Cardiovascular afferents involved in regulation of peripheral vessels. Annu Rev Physiol 1980;42: 413-27.
27. Coleridge HM, Coleridge JCG, Dangel A, Kidd C, Luck JC, Sleight P. Impulses in slowly conducting vagal fibers from afferent endings in the veins, atria, and arteries of dogs and cats. Circ Res 1973;33:87-97.
28. Coleridge HM, Coleridge JCG, Kidd C. Cardiac receptors in the dog, with particular reference to two types of afferent endings in the ventricular wall. J Physiol 1964;174:323-39.
29. Coote JH. Spinal and supraspinal reflex pathways of cardio-cardiac sympathetic reflexes. Neurosci Lett 1984;46:243-7.
30. Cornish KG, Gilmore JP, McCulloch T. Central blood volume and blood pressure in conscious primates. Am J Physiol 1988;254: H693-701.
31. Cowley AW, Norman RA, Coleman TG, Samar RE. The arterial baroreceptor reflex, a pressure buffering system. In: Guyton AC, ed. Arterial pressure and hypertension. New York: Saunders Press, 1980a:248-65. (Circulatory physiology III.)
32. Cowley AW, Quillen EW, Barber BJ. Further evidence for lack of baroreceptor control of long-term level of arterial pressure. In: Sleight P, ed. Arterial baroreceptors and hypertension. Oxford, UK: Oxford University Press, 1980b:391-8.
33. Daly ID, Hassledine JL, Ungar A. The reflex effects of alterations in lung volume on systemic vascular resistance in the dog. J Physiol 1967;188:331-51.
34. Daly ID, Verney EB. The localization of receptors involved in the reflex regulation of the heart rate. J Physiol 1927;62:330-40.
35. Dawes GS, Comroe JH. Chemoreflexes from the heart and lungs. Physiol Rev 1954;34:167-201.
36. Drinkhill MJ, Vacca G, Mary DA. Efferent limb of the atrial receptors reflex decrease in plasma renin activity in anaesthetized dogs. Q J Exp Physiol 1989;74:503-9.
37. Ead HW, Green JH, Neil E. A comparison of the effects of pulsatile and non-pulsatile blood flow through the carotid sinus on the reflexogenic activity of sinus baroreceptors in the cat. J Physiol 1952; 118:509-19.
38. Eckberg DL. High- and low-pressure baroreflexes. In: Robertson D, Low PA, Polinsky RJ, eds. Primer on the autonomic nervous system. New York: Academic Press, 1996:59-65.
39. Eckberg DL. Parasympathetic cardiovascular control in human disease: a critical review of methods and results. Am J Physiol 1980;239:H581-93.
40. Eckberg DL. Baroreflex inhibition of the human sinus node: importance of stimulus intensity, duration, and rate of pressure change. J Physiol 1977;269:561-77.
41. Eckberg DL, Fletcher GF, Braunwald E. Mechanisms of prolongation of the R-R interval with electrical stimulation of the carotid sinus nerves in man. Circ Res 1972;30:131-8.
42. Eckberg DL, Sleight P, eds. Human baroreflexes in health and disease. Oxford, NY: Clarendon Press, 1992.
43. Edis AJ, Donald DE, Shepherd JT. Cardiovascular reflexes from stretch of pulmonary vein-atrial junctions in the dog. Circ Res 1970;27:1091-100.
44. Egan BM, Julius S, Cottier C, Osterziel KJ, Ibsen H. Role of cardiovascular receptors on the neural regulation of renin release in normal men. Hypertension 1983;5:779-86.
45. Emery DG, Foreman RD, Coggeshall RE. Fiber analysis of the feline inferior cardiac sympathetic nerve. J Comp Neurol 1976;166: 457-68.
46. Ewing DJ, Hume L, Campbell IW, Murray A, Neilson JM, Clarke BF. Autonomic mechanisms in the initial heart rate response to standing. J Appl Physiol 1980;49:809-14.
47. Felder RB, Thames MD. Responses to activation of cardiac sympathetic afferents with epicardial bradykinin. Am J Physiol 1982; 242:H148-53.
48. Fidone SJ, Sato A. A study of chemoreceptor and baroreceptor A-and C-fibers in the cat carotid nerve. J Physiol 1969;205:527-48.
49. Fitzpatrick AP, Banner NA, Cheng A, Yacoub M, Sutton R. Vasovagal reactions may occur after orthotopic heart transplantation. J Am Coll Cardiol 1993;21:1132-7.
50. Furnival CM, Linden RJ, Snow HM. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure. J Physiol 1970;211:359-87.
51. Furnival CM, Linden RJ, Snow HM. Reflex effects on the heart of stimulating left atrial receptors. J Physiol (Lond) 1971;218: 447-63.
52. Gauer OH, Henry JP. Circulatory basis of fluid volume control. Physiol Rev 1963;43:423-81.
53. Gilmore JP, Zucker IH. Discharge of type-B atrial receptors during changes in vascular volume and depression of atrial contractility. J Physiol 1974;239:207-23.
54. Grassi G, Gavazzi C, Ramirez A, Sabadini E, Turolo L, Mancia G. Role of cardiopulmonary receptors in reflex control of renin release in man. Hypertension 1985;2(suppl 3):263-5.
55. Grubb BP, Kosinski DJ. Neurocardiogenic syncope. In: Robertson D, Low PA, Polinsky RJ, eds. Primer on the autonomic nervous system. New York: Academic Press, 1996:179-82.
56. Gupta BN, Thames MD. Behavior of left ventricular mechanoreceptors with myelinated and nonmeylinated afferent vagal fibers in cats. Circ Res 1983;52:291-301.
57. Hainsworth R. Reflexes from the heart. Physiol Rev 1991;71:617-51.
58. Henry JP, Pearce JW. The possible role of cardiac atrial stretch receptors in the induction of changes in urine flow. J Physiol 1956;131:572-85.
59. Hering HE. Über die abhängigkeit der bei Lungenaufblasung und bei der respiratorischen Arrhythmic auftretenden Frequenzänderungen des Herzens von den Blut druckzüglern. Z-Kreislaufforshung 1930;22:593-8.
60. Hess GL, Zuperku EJ, Coon RL, Kampine JP. Sympathetic afferent nerve activity of left ventricular origin. Am J Physiol 1974;227:543-6.
61. Holmes RL. Cholinesterase in the atrial wall of the dog and cat heart. J Physiol 1957;137:421-6.
62. Hubbard SJ. A study of rapid mechanical events in a mechanoreceptor. J Physiol 1958;141:198-218.
63. Jarisch A, Richter H. Depressor reflexes from the heart. Acta Physiol Scand 1948;16:31-51.
64. Jarisch A, Richter H. Die afferenten Bahnen des Veratrine Effektes in den Herznerven. Arch Exp Pathol Pharmakol 1939;193:355-71.
65. Jarisch A, Zotterman Y. Depressor reflexes from the heart. Acta Physiol Scand 1948;16:31-51.
66. Julius S, Cottier C, Egan B, Ibsen H, Kiowski W. Cardiopulmonary mechanoreceptors and renin release in humans. Fed Proc 1983; 42:2703-8.
67. Kappagoda CT, Linden RJ, Mary DASG. Atrial receptors in the cat. J Physiol 1976;262:431-6.
68. Kappagoda CT, Linden RJ, Snow HM. A reflex increase in heart rate from distension of the junction between the superior vena cava and the right atrium. J Physiol 1972a;220:177-97.
69. Kappagoda CT, Linden RJ, Saunders DA. The effect on heart rate of distending the atrial appendages in the dog. J Physiol 1972b;225:705-19.
70. Kardon MB, Peterson DF, Bishop VS. Reflex heart rate control via specific aortic nerve afferents in the rabbit. Circ Res 1975; 37:41-7.
71. Kaufman MP, Baker DG, Coleridge HM. Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog. Circ Res 1980;46:476-84.
72. Kaufmann H. Neurally mediated syncope: pathogenesis, diagnosis, and treatment. Neurology 1995;45(suppl 5):S12-8.
73. Kirchheim HR. Systemic arterial baroreceptor reflexes. Physiol Rev 1976;56:100-76.
74. Koch E. Die reflektorische Selbststeuerung des Kreislaufes. In: Kisch B, eds. Ergebnnisse der Kerislaufforschung. Dresden: Stienkopff, 1931.
75. Krauhs JM. Structure of rat aortic baroreceptors and their relationship to connective tissue. J Neurocytol 1979;8:401-14.
76. Landgren S. On the excitation mechanism of the carotid baroreceptors. Acta Physiol Scand 1952;26:1-34.
77. Ledsome JR, Linden RJ. A reflex increase in heart rate from distension of the pulmonary vein-atrial junctions. J Physiol 1964; 170:456-73.
78. Ledsome JR, Mason JM. The effects of vasopressin on the diuretic response to left atrial distension. J Physiol 1972;221:427-40.
79. Ledsome JR, Ngsee J, Wilson N. Plasma vasopressin concentration in the anaesthetized dog before, during and after atrial distension. J Physiol 1983;338:413-21.
80. Levy MN, Martin PJ. Neural control of the heart. In: Handbook of physiology - the cardiovascular system I. Baltimore: Waverly Press, 1979.
81. Linden RJ. Function of cardiac receptors. Circulation 1973;48:463-80.
82. Linden RJ, Kappagoda CT, eds. Atrial receptors. Cambridge, U.K.: Cambridge University Press, 1982.
83. Longhurst JC. Cardiac receptors: their function in health and disease. Prog Cardiovasc Dis 1984;27:201-22.
84. Ludbrook J. Cardiovascular reflexes from cardiac sensory receptors. Aust NZ J Med 1990;20:597-606.
85. Malliani A, Peterson DF, Bishop VS, Brown AM. Spinal sympathetic cardiocardiac reflexes. Circ Res 1972;30:158-66.
86. Malliani A. Cardiovascular sympathetic afferent fibers. Rev Physiol Biochem Pharmacol 1982;95:11-74.
87. Malliani A, Recordati G, Schwartz PJ. Nervous activity of afferent sympathetic fibers with atrial and ventricular endings. J Physiol 1973;229:457-69.
88. Malliani A, Schwartz PJ, Banks R, et al. Reflex responses of sympathetic preganglionic neurones initiated by different cardiovascular receptors in spinal animals. Brain Res 1974;68:215-25.
89. Mancia G, Mark, AL. Arterial baroreflexes in humans. In: Shepherd JT, Abboud FM, eds. Handbook of Physiology. Section 2: The cardiovascular system, Volume 3, Part 2, Am Physiol Soc. Washington, DC: Williams and Wilkins, 1983:755-93.
90. Mancia G, Ferrari A, Gregorini L, Ludbrook J, Zanchetti A. Baroreceptor control of heart rate in man. In: Schwartz PJ, Brown AM, Malliani A, Zanchetti A, eds. Neural mechanisms of cardiac arrhythmias. New York: Raven Press, 1978:323-33.
91. Mancia G, Ferrari A, Gregorini L, Parity G, Pomidossi G, Zanchetti A. Control of blood pressure by carotid sinus baroreceptors in human beings. Am J Cardiol 1979;44:895-902.
92. Mancia G, Iannos J, Jamieson GG, Lawrence RH, Sharman PR, Ludbrook J. Effect of isometric hand-grip exercise on the carotid sinus baroreceptor reflex in man. Clin Sci Mol Med 1978;54:33-7.
93. Marin Neto JA, Gallo L, Manco JC, Rassi A, Amorim DS. Mechanisms of tachycardia on standing: studies in normal individuals and in chronic Chagas' heart patients. Cardiovasc Res 1980; 14:541-50.
94. Mark AL, Abboud FM, Fitz AE. Influence of low and high-pressure baroreceptors on plasma renin activity in humans. Am J Physiol 1978;235:H29-33.
95. Mathias CJ, Frankel HL. Autonomic disturbances in spinal cord lesions. In: Bannister R, Mathias, CJ, eds. Autonomic failure: textbook of clinical disorders. New York: Oxford University Press, 1992:839-53.
96. Mathias CJ, Christensen NJ, Corbett JL, Frankel HL, Spalding JMK. Plasma catecholamines during paroxysmal neurogenic hypertension in quadriplegic man. Circ Res 1976;39:204-8.
97. Mifflin SW, Felder RB. Synaptic mechanisms regulating cardiovascular afferent inputs to solitary tract nucleus. Am J Physiol 1990;259:H653-61.
98. Miller MR, Kasahara M. Studies on nerve endings in the heart. Am J Physiol 1964;115:217-34.
99. Morgan DA, Thoren P, Wilczynski EA, Victor RG, Mark AL. Serotonergic mechanisms mediate renal sympathoinhibition during severe hemorrhage in rats. Am J Physiol 1988;255:H496-502.
100. Muers MF, Sleight P. The reflex cardiovascular depression caused by occlusion of the coronary sinus in the dog. J Physiol 1972; 221:259-82.
101. Murray RH, Shropshire S. Effect of atropine on circulatory responses to lower body negative pressure and vasodepressor syncope. Aero Med 1970;41:717-22.
102. Nettleship WA. Experimental studies on the afferent innervation of the cat's heart. J Comp Neurol 1936;64:115-33.
103. Nishi K, Takenaka F. Chemosensitive afferent fibers in the cardiac sympathetic nerve of the cat. Brain Res 1973;55:214-8.
104. Nonidez JF. Identification of the receptor areas in the venae cavae and the pulmonary veins which initiate reflex cardiac acceleration (Bainbridge's reflex). Am J Anat 1937;61:203-31.
105. Oberg B, Thoren P. Increased activity in vagal cardiac afferents correlated to the appearence of reflex bradycardia during severe hemorrhage in cats [Abstract]. Acta Physiol Scand 1970;80: 22A-23A.
106. Oberg B, Thoren P. Studies on left ventricular receptors, signaling in non-medullated vagal afferents. Acta Physiol Scand 1972a; 85:145-63.
107. Oberg B, Thoren P. Increased activity in left ventricular receptors during hemorrhage or occlusion of caval veins in the cat. A possible cause of the vaso-vagal reaction. Acta Physiol Scand 1972b;85:164-73.
108. Pagani M, Pizzinelli P, Furlan R, et al. Analysis of the pressor sympathetic reflex produced by intracoronary injections of bradykinin in conscious dogs. Circ Res 1985;56:175-83.
109. Paintal AS. Natural stimulation of type B atrial receptors. J Physiol 1963;169:116-36.
110. Paintal AS. A study of right and left atrial receptors. J Physiol 1953a;120:596-10.
111. Paintal AS. The conduction velocities of the respiratory and cardiovascular afferent fibers in the vagus nerve. J Physiol 1953b; 121:341-59.
112. Peterson DF, Brow AM. Pressor reflexes produced by stimulation of afferent fibers in the cardiac sympathetic nerves of the cat. Circ Res 1971;28:605-10.
113. Recordati G, Lombardi F, Bishop VS, Malliani A. Response of type B atrial vagal receptors to change in wall tension during atrial filling. Circ Res 1975;36:682-91.
114. Reimann KA, Weaver LC. Contrasting reflexes evoked by chemical activation of cardiac afferent nerves. Am J Physiol 1980;239: H316-25.
115. Rubin A, Rials S, Marinchak R, Kowey P. The head up tilt table test and cardiovascular neurogenic syncope. Am Heart J 1993;125:476-82.
116. Sagawa K, Kumada M, Schmidt RM. Cardiovascular response to various pulsatile pressures in the carotid sinus. Am J Physiol 1972;223:1-7.
117. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone? Circ Res 1992; 70:607-11.
118. Samiol D, Grubb BP, Brewster P, Moore J, Temesy-Armos P. Comparison of single and dual chamber pacing techniques in prevention of upright tilt induced vasovagal syncope. Eur J Cardiac Pacing Electrophysiol 1993;1:36-41.
119. Scherrer U, Vissing S, Morgan BJ, Hanson P, Victor RG. Vasovagal syncope after infusion of a vasodilator in a heart-transplant recipient. N Engl J Med 1990;322:602-4.
120. Schwartz PJ, Pagani M, Lombardi F, Malliani A, Brown AM. A cardiogenic sympathovagal reflex in the cat. Circ Res 1973; 32:215-20.
121. Shalev Y, Gal R, Tchou PJ, et al. Echocardiographic demonstration of decreased left ventricular dimensions and vigorous myocardial contraction during syncope induced by head-up tilt. J Am Coll Cardiol 1991;18:746-51.
122. Shepherd JT, Mancia G. Reflex control of the human cardiovascular system. Rev Physiol Biochem Pharmacol 1986;105:1-99.
123. Sleight P. A cardiovascular depressor reflex from the epicardium of the left ventricle in the dog. J Physiol 1964;173:321-43.
124. Sleight P, Widdicombe JG. Action potentials in afferent fibers from pericardial mechanoreceptors in the dog. J Physiol 1965;181: 259-69.
125. Smith ML, Beightol LA, Fritsch-Yelle JM, Ellenbogen KA, Porter TR, Eckberg DL. Valsalva's maneuver revisited: a quantitative method yielding insights into human autonomic control. Am J Physiol 1996;271:H1240-9.
126. Sneddon JF, Counihan PJ, Bashir Y, et al. Assessment of autonomic function in patients with neurally mediated syncope: augmented cardiopulmonary baroreceptors responses to graded orthostatic stress. J Am Coll Cardiol 1993;21:1193-8.
127. Somers VK, Mark AL. The Bezold-Jarisch reflex. In: Robertson D, Low PA, Polinsky RJ, eds. Primer on the autonomic nervous system. New York: Academic Press, 1996:66-9.
128. Sra JS, Anderson AJ, Sheik SH, et al. Unexplained syncope evaluated by electrophysiologic studies and head-up tilt testing. Ann Intern Med 1991;114:1013-9.
129. Sra JS, Jazayeri MR, Avitall B, et al. Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia of asystole. N Engl J Med 1993;328:1085-90.
130. Staszewska-Barczak J. The reflex stimulation of catecholmine secretion during the acute stage of myocardial infarction in the dog. Clin Sci 1971;41:419-39.
131. Staszewska-Woolley J, Woolley G, Regoli D. Specific receptors for bradykinin-induced cardiac sympathetic chemoreflex in the dog. Eur J Pharmocal 1988;156:309-14.
132. Thames MD. Reflex suppression of renin released by ventricular receptors with vagal afferents. Am J Physiol 1977;233: H181-4.
133. Thames MD. Effect of d-and l-propranolol on the discharge of cardiac vagal C-fibers. Am J Physiol 1980;238:H465-70.
134. Thoren P. Activation of left ventricular receptors with non-medullated vagal afferent fibers during occlusion of a coronary artery in the cat. Am J Cardiol 1976;37:1046-51.
135. Thoren P. Characteristics of left ventricular receptors with non-medullated vagal afferents in cats. Circ Res 1977;40:231-7.
136. Thoren P. Left ventricular receptors activated by severe asphyxia and by coronary occlusion. Acta Physiol Scand 1972;85:455-63.
137. Thoren P, Skarphedinsson JO, Carlsson S. Sympathetic inhibition from vagal afferents during severe hemorrhage in rats. Acta Physiol Scand 1988;133(suppl 571):97-105.
138. Uchida Y. Afferent sympathetic nerve fibers with mechanoreceptors in the right heart. Am J Physiol 1975;228:223-30.
139. Uchida Y, Murao S. Excitation of afferent cardiac sympathetic nerve fibers during coronary occlusion. Am J Physiol 1974;226: 1094-9.
140. Ueda M, Frohlich ED, Tarazi RC, Dustan HP, Page IH. Centrally mediated vasopressor effect of angiotension II in man. Jpn Heart J 1969;10:243-7.
141. Whitteridge D. Afferent nerve fibers from the heart and lungs in the cervical vagus. J Physiol 1948;107:496-512.
142. Zucker IH, Share L, Gilmore JP. Renal effects of left atrial distension in dogs with chronic congestive heart failure. Am J Physiol 1979;236:554-60.