Glial and neuronal expression of cyclooxygenase-2: Relevance to Alzheimer's disease

Advances in Experimental Medicine and Biology

Volumn 433, Issue , 1997, Pages 177-180

  Kerry O'Banion, M ^a  

^a Department of Neurology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; ENZYME SYNTHESIS; GLIA CELL; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; ANIMALS; ASTROCYTES; BRAIN; CYCLOOXYGENASE 2; CYTOKINES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; NEUROGLIA; NEURONS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0031394006     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (16)

1. Bauer, M.K.A., Lieb, K., Schulzeostohoff, K., Berger, M., Gebicke-Haerter, P.J., Bauer, J., and Fiebich, B.L., 1997, Expression and regulation of cyclooxygenase-2 in rat microglia, Eur. J. Biochem. 243:726.
2. Breder, C.D., DeWitt, D., and Kraig, R.P., 1995, Characterization of inducible cyclooxygenase in rat brain, J. Comp. Neurol. 355:296.
3. Breitner, J.C.S., 1996, Inflammatory processes and antiinflammatory drugs in Alzheimer's disease: a current appraisal, Neurobiol. Aging 17:789.
4. Chang, J.W., Coleman, P.D., and O'Banion, M.K., 1996, Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease, Neurobiol. Aging 17:801.
5. 2a-receptors, Glia 18:152.
6. Kaufmann, W.E., Worley, P.F., Pegg, J., Bremer, M., and Isakson, P., 1996, Cox-2, a synaptically-induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex, Proc. Natl. Acad. Sci. USA 93:2317.
7. McGeer, P.L., and McGeer, E.G., 1995, Chronic inflammatory mechanisms of the brain: implications for the treatment of Alzheimer disease, Dementia 9:111.
8. Minghetti, L., Polazzi, E., Nicolini, A., Créminon, C., and Levi, G., 1996, Interferon gamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression, J. Neurochem. 66:1963.
9. O'Banion, M.K., Coleman, P.D., and Callahan, L.M., 1994, Regional neuronal loss in aging and Alzheimer's disease: a brief review, Sem. Neurosci. 6:307.
10. O'Banion, M.K., Dusel, J.C., Chang, J.W., Kaplan, M.D., and Coleman, P.D., 1996, Interleukin-1 induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures, J. Neurochem. 66:2532.
11. O'Banion, M.K., Winn, V.D., and Young, D.A., 1992, cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase, Proc. Natl. Acad. Sci. USA 89:4888.
12. Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L., Kasznaik, A.W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P., and Kogan, F., 1993, Clinical trial of indomethacin in Alzheimer's disease, Neurology 43:1609.
13. Rogers, J., Webster, S., Lue, L.-F., Brachova, L., Civin, W.H., Emmerling, M., Shivers, B., Walker, D., and McGeer, P., 1996, Inflammation and Alzheimer's disease pathogenesis, Neurobiol. Aging 17:681.
14. Stewart, W.F., Kawas, C., Corrada, M., and Metter, E.J., 1997, Risk of Alzheimer's disease and duration of NSAID use, Neurology 48:626.
15. Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A., and Katzman, R., 1991, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol. 30:572.
16. Yamagata, K., Andreasson, K.I., Kaufmann, W.I., Barnes, C.A., and Worley, P.F., 1993, Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids, Neuron 11:371.