Hemolytic and antifungal activity of liposome-entrapped amphotericin B prepared by the precipitation method

Pharmaceutical Development and Technology

Volumn 2, Issue 3, 1997, Pages 275-284

  Kim, Jin Chul ^a   Lee, Eun Ok ^b   Kim, Jong Yun ^a   Bae, Soo Kyoung ^a   Choi, Tae Boo ^c   Kim, Jong Duk ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Doosan Technical Center   (South Korea)

^c Konkuk University   (South Korea)

Author keywords

Amphotericin B; Antifungal activity; Liposome; Precipitation; Toxicity

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; DRUG VEHICLE; LIPOSOME; PHOSPHATIDYLCHOLINE;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; HEMOLYSIS; HUMAN; HUMAN CELL; MYCOSIS; PRIORITY JOURNAL;

EID: 0031392375     PISSN: 10837450     EISSN: None     Source Type: Journal    
DOI: 10.3109/10837459709031447     Document Type: Article

References (24)

1. P. E. Hermans and T. F. Keys, Antifungal agents used for deep-seated mycotic infections, Mayo Clin. Proc., 58, 223-231 (1983).
2. R. Horn, B. Wong, T. E. Kiehn, and D. Amstrong, Fungemia in a cancer hospital: changing frequency, earlier onset, and results of therapy, Rev. Infect. Dis., 7, 646-655 (1985).
3. V. E. Khutorsky, Structures of amphotericin B-cholesterol complex, Biochim. Biophys. Acta, 1108, 123-127 (1992).
4. P. V. Hoogevest and B.D. Kruijff, Effect of amphotericin B on cholesterol-containing liposomes of egg phosphatidylcholine and didocosenoyl phosphatidyl-choline - A refinement of the model for the formation of pores by amphotericin B in membranes, Biochim. Biophys. Acta, 511, 397-407 (1978).
5. B. De Kruijff and R. A. Demel, Polyene antibiotic-sterol interactions in membranes of Acholeplasma Laidlawii cells and lecithin liposomes. II. Temperature dependence of the polyene antibiotic-sterol complex formation, Biochim. Biophys. Acta, 339, 44-56 (1974).
6. R. Bittman, W. C. Chen, and O. R. Anderson, Interaction of Filipin III and amphotericin B with lecithin-sterol vesicles and cellular membrane.- Spectral and electron microscope studies, Biochemistry, 13, 1364-1373 (1974).
7. J. Kotler-Brajtburg, G. Medoff, G.S. Kobayashi, S. Boggs, D. Schlessinger, R.C. Pandey, and K. L. Rinehart Jr, Classification of polyene antibiotics according to chemical structure and biological effects, Antimicrob. Agent Chemother., 15, 716-722 (1979).
8. T. H. Adams, R. G. Wong, and A. W. Norman, Studies on the mechanism of action of calciferol. II. Effects of the polyene antibiotic, Filipin, on vitamin D-mediated calcium transport, J. Biol. Chem., 245, 4432-4442 (1970).
9. J. L. Burgess and R. Birchall, Nephrotoxicity of amphotericin B with emphasis on changes in tubular function, Am. J. Med., 53, 77-84 (1972).
10. G. Lopez-Berestein and R. L. Juliano, Application of liposomes to the delivery of antifungal agents, in Liposomes: From Biophysics to Therapeutics (M. J. Ostro, ed.), Marcel Dekker, Inc., New York, 1987, pp. 253-276.
11. R. Mehta, G. Lopez-Berestein, R. Hopfer, K. Mills, and R.L. Juliano, Liposomal amphotericin B is toxic to fungal cell but not to mammalian, Biochim. Biophys. Acta, 770, 230-243 (1984).
12. G. Lopez-Berestein, R. Mehta, R.,L. Hopfer, K. Mills, L. Kasi, K. Mehta, V. Fainstein, M. Luna, E. M. Hersh, and R. Juliano, Treatment and prophylaxis of disseminated infection due to Candida albicans in mice with liposome-encapsulated amphotericin, B. J. Infect. Dis., 147, 939-945 (1983).
13. C. Tremblay, M. Barza, C. Fiore, and F. Szoka, Efficacy of liposome-intercalated amphotericin B in the treatment of systemic candidiasis in mice, Antimicrob. Agents Chemother., 26, 170-173 (1984).
14. G. Lopez-Berestein, V. Fainstein, R. Hopfer, K. Mehta, M. P. Sullivan, M. Keating, M. G. Rosenblum, R. Mehta, M. Luna, E. M. Hersh, J. Reuben, R. L. Juliano, and G. P. Bodey, Liposomal amphotericin B for treatment of systemic fungal infections in patients with cancer: a preliminary study, J. Infect. Dis., 151, 704-710 (1985).
15. G. Lopez-Berestein, R. Mehta, R. Hopfer, K. Mehta, E. M. Hersh and R. L. Juliano, Effects of sterols on the therapeutic efficacy of liposomal amphotericin B in murine candidiasis, Cancer Drug Delivery, 1, 37-41 (1983).
16. R. L. Juliano, C. M. W. Grant, K. R. Barber, and M. A. Kalp. Mechanism of the selective toxicity of amphotericin B incorporated into liposomes, Molecular Pharmacol., 31, 1-11 (1986).
17. L. Boni, P. R. Cullis, A. G. Durning, A. S. Janoff, J. J. Kearns, R. Klimchak, R. P. Lenk, T. Madden, and J. Portnoff, Low toxicity drug-lipid systems, European Patent Specification 0282405B1 (1995).
18. V. E. Vaskovsky, E. Y. Kostetsky, and I. M. Vasendin. A universal reagent for phospholipid analysis, J. Chromatogr., 114, 129-141 (1975).
19. S. Jullien, J. Brajtburg, and J. Bolard, Affinity of amphotericin B for phosphatidylcholine vesicles as a determinant of the in vitro cellular toxicity of liposomal preparations, Biochim. Biophys. Acta, 1021, 39-45 (1990).
20. W. R. Perkins, S. R. Minchey, L. T. Boni, C. E. Swenson, M. C. Popescu, R. F. Pasternack, and A. S. Janoff, Amphotericin B-phospholipid interactions responsible for reduced mammalian cell toxicity, Biochim. Biophys. Acta, 1107, 271-282 (1992).
21. J. Borlard, M. Seigneret, and G. Boudet, Interaction between phospholipid bilayer membranes and the polyene antibiotic amphotericin B - Lipid state and cholesterol content dependence, Biochim. Biophys. Acta, 599, 280-293 (1980).
22. A. R. Balakrishnan and K. R. K. Easwaran, CD and NMR studies on the aggregation of amphotericin B in solution, Biochim. Biophys. Acta, 1148, 269-277 (1993).
23. J.-C. Kim, E.-O. Lee, J. W. Yang, T. B. Choi, and J.-D. Kim, Complexation of amphotericin B with egg phosphatidylcholine liposomes, Archives of Pharmaceutic, 18, 84-89 (1995).
24. A. S. Janoff, L. T. Boni, M. C. Popescu, S. R. Minchey, P. R. Cullis, T. D. Madden, T. Taraschi, S. M. Gruner, E. Shyamsunder, M. W. Tate, R. Mendelsohn, and D. Bonner, Unusual lipid structures selectively reduce the toxicity of amphotericin B, Proc. Natl. Acad. Sci., 85, 6122-6126 (1988).