Synthesis and antinociceptive activity of [D-Ala2]Leu-enkephalin derivatives conjugated with the adamantane moiety

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 11, 1997, Pages 1782-1787

  Kitagawa, Kouki ^a   Mizobuchi, Noriko ^b   Hama, Teruo ^b   Hibi, Tohru ^b,d   Konishi, Ryoji ^b   Futaki, Shiroh ^c  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b Teikoku Seiyaku Co Ltd   (Japan)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d JAPAN TOBACCO INC   (Japan)

Author keywords

Adamantane; Brain directed delivery; Chemical conjugation; Drug carrier; Enkephalin; Lipophilicity

Indexed keywords

LEUCINE ENKEPHALIN DERIVATIVE; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE];

AMINO TERMINAL SEQUENCE; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; DRUG ABSORPTION; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031392169     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1782     Document Type: Article

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