Lung distribution of intratracheally instilled99mTc-tobramycin-surfactant mixture in rats with a Klebsiella pneumoniae lung infection

Applied Cardiopulmonary Pathophysiology

Volumn 7, Issue 2, 1997, Pages 87-94

  Van Veen, Annemarie 't ^a   Wollmer, Per ^b   Nilsson, Lars Erik ^a   Gommers, Diederik ^a   Mouton, Johan W ^a   Kooij, Peter P M ^b   Lachmann, Burkhard ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

99mtc tobramycin; Local antimicrobial therapy; Lung distribution; Lung infection; Pulmonary surfactant; Surfactant as carrier

Indexed keywords

ANTIBIOTIC AGENT; DRUG VEHICLE; LUNG SURFACTANT; SURFACTANT; TECHNETIUM 99M; TOBRAMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; KLEBSIELLA PNEUMONIAE; LUNG INFECTION; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT;

EID: 0031391758     PISSN: 09205268     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Ilowite JS, Gorvoy JD, Smaldonc GC. Quantitative deposition of aerosolized gentamicin in cystic fibrosis. Am Rev Respir Dis 1987; 136: 1445-9.
2. Mukhopadhyay S, Staddon GE, Eastman C, Palmer M, Davies ER, Carswell F. The quantitative distribution of nebulized antibiotic in the lung in cystic fibrosis. Respir Med 1994; 88: 203-11.
3. Brown RB, Kruse JA, Counts GW, Russel JA, Christou NV, Sands ML. Double-blind study of endotracheal tobramycin in the treatment of gram-negative bacterial pneumonia. Antimicrob Agents Chemother 1990; 34: 269-72.
4. Bressolle F, De La Coussaye J-E, Ayoub R, Fabre D, Gomeni R, Saissi G, Eledjam J-J, Galtier M. Endotracheal and aerosol administration of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability. Antimicrob Agents Chemother 1992; 36: 1404-11.
5. Debs RJ, Straubinger RM, Brunette EN, Lin JM, Lin EJ, Montgomery AB, Friend DS, Papahadjopoulos DP. Selective enhancement of pentamidine uptake in the lung by aerosolization and delivery in liposomes. Am Rev Respir Dis 1987; 135: 731-7.
6. Brain JD, Knudson DE, Sorokin SP, Davis MA. Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ Res 1976; 11: 13-33.
7. Kharasch VS, Sweeney TD, Fredberg J, Lehr J, Damokosh AI, Avery ME, Brain JD. Pulmonary surfactant as a vehicle for intratracheal delivery of technetium sulfur colloid and pentamidine in hamster lungs. Am Rev Respir Dis 1991; 144: 909-13.
8. Van 't Veen A, Gommers D, Mouton JW, Kluytmans JAJW, Krijt EJ, Lachmann B. Exogenous pulmonary surfactant as a drug delivering agent: influence of antibiotics on surfactant activity. Br J Pharmacol 1996; 118: 595-8.
9. Van 't Veen A, Mouton JW, Gommers D, Kluytmans JAJW, Dekkers P, Lachmann B. Influence of pulmonary surfactant on in vitro bactericidal activities of amoxicillin, ceftazidime, and tobramycin. Antimicrob Agents Chemother 1995; 39: 329-33.
10. Van 't Veen A, Mouton JW, Gommers D, Lachmann B. Pulmonary surfactant as vehicle for intratracheally instilled tobramycin in mice infected with Klebsiella pneumoniae. Br J Pharmacol 1996; 119: 1145-8.
11. Gommers D, Lachmann B. Surfactant therapy: does it have a role in adults? Clin Intensive Care 1993; 4: 284-95.
12. Lachmann B, Gommers D. Is it rational to treat pneumonia with exogenous surfactant? Eur Respir J 1993; 6: 1437-8.
13. Liu M, Wang L. Li E, Enhorning G. Pulmonary surfactant will secure free airflow through a narrow tube. J Appl Physiol 1991; 71: 742-8.
14. Enhorning G, Duffy LC. Welliver RC. Pulmonary surfactant maintains patency of conducting airways in the rat. Am J Respir Crit Care Med 1995; 151: 554-6.
15. 99mTc and biodistribution. J Radioanal Nucl Chem 1988; 125:203-11.
16. Gommers D, Vilstrup C, Bos JAH, Larsson A, Werner O, Hannappel E, Lachmann B. Exogenous surfactant therapy increases static lung compliance and cannot be assessed by measurements of dynamic compliance alone. Crit Care Med 1993; 21: 567-74.
17. Roosendaal R, Bakker-Woudenberg IAJM, Van den Berghevan Raffe M, Vink-van den Berg JC, Michel MF. Impact and duration of infection on the activity of ceftazidime, gentamycin and ciprofloxacin in Klebsiella pneumoniae pneumonia and septicemia in leukopenic rats. Eur J Clin Microbiol Infect Dis 1991; 10: 1019-25.
18. Kanekal S, Sahai A, Jones RE, Brown D. Storage-phosphor autoradiography: a rapid and highly sensitive method for spatial imaging and quantitation of radioisotopes. J Pharmacological Toxicological Methods 1995; 33: 171-8.
19. 99mTc-DTPA clearance. J Appl Physiol 1986; 60: 1461-5.
20. Israel KS, Welles JS, Black HR. Aspects of the pharmacology and toxicology of tobramycin in animals and humans. J Infect Dis 1976; S134: 97-103.
21. Gilliard N, Richman PM, Merritt TA, Spragg RG. Effect of volume and dose on the pulmonary distribution of exogenous surfactant administered to normal rabbits or to rabbits with oleic acid lung injury. Am Rev Respir Dis 1990; 141: 743-7.
22. Van der Bleek J, Plötz FB, Van Overbeek M, Heikamp A, Beekhuis H, Wildevuur ChRH, Okken A, Bambang Oetomo S. Distribution of exogenous surfactant in rabbits with severe respiratory failure: the effect of volume. Pediatr Res 1993; 34: 154-8.
23. Davis JM, Russ GA, Metlay L, Dickerson B, Greenspan BS. Short-term distribution kinetics of intratracheally administered exogenous lung surfactant. Pediatr Res 1992; 31: 445-50.
24. Segerer H, Van Gelder W, Angenent FWM, Van Woerkens LJPM, Curstedt T, Obladen M, Lachmann B. Pulmonary distribution and efficacy of exogenous surfactant in lung-lavaged rabbits are influenced by the instillation technique. Pediatr Res 1993; 34: 490-4.
25. Ueda T, Ikegami M, Rider ED, Jobe AH. Distribution of surfactant and ventilation in surfactant-treated preterm lambs. J Appl Physiol 1994; 76: 45-55.
26. Lewis JF, McCaig L. Aerosolized versus instilled exogenous surfactant in a nonuniform pattern of lung injury. Am Rev Respir Dis 1993; 148: 1187-93.