CGP57698: A structurally simple, highly potent peptido-leukotriene (PLT) antagonist of the quinoline type

Advances in Experimental Medicine and Biology

Volumn 433, Issue , 1997, Pages 169-172

  Von Sprecher, Andreas ^a   Gerspacher, Marc ^a   Beck, Andreas ^a   Anderson, Gary P ^a   Niederhauser, Ulrich ^a   Subramanian, Natarajan ^a   Ball, Howard A ^a   Gentsch, Conrad ^a   Vassout, Annick ^a   Feiner, Aina ^a   Bittiger, Helmut ^a   Hauser, Kathleen ^a   Giese, Karl ^a   Kraetz, Joseph ^a   Bray, Michael A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIETHYL 4 [3 (7 FLUORO 2 QUINOLINYLMETHOXY)ANILINO] 4 OXOBUTYRIC ACID; CLONIDINE; DIHYDROALPRENOLOL; GRANISETRON; KETANSERIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEPYRAMINE; MONTELUKAST; NALOXONE; PRAZOSIN; SEROTONIN; UNCLASSIFIED DRUG; ZAFIRLUKAST;

ANIMAL TISSUE; ARTICLE; BRONCHODILATATION; BRONCHOSPASM; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; GUINEA PIG; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION;

ACETATES; ANIMALS; ANTI-ASTHMATIC AGENTS; BRONCHOCONSTRICTION; GUINEA PIGS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE D4; LUNG; MOLECULAR STRUCTURE; MUSCLE, SMOOTH; QUINOLINES; TOSYL COMPOUNDS;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0031391214     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4899-1810-9_34     Document Type: Article

References (5)

1. C.D.W. Brooks, and J.B. Summers, Modulators of leukotriene biosynthesis and receptor activation, J. Med. Chem. 39:2629-2654 (1996).
2. A. von Sprecher, A. Beck, M. Gerspacher, and M.A. Bray, Peptidoleukotriene antagonists: state of the art, Chimia. 46: 304-311 (1992).
3. A. von Sprecher, A. Beck, M. Gerspacher, A. Sallmann, G.P. Anderson, N. Subramanian, U. Niederhauser, and M.A. Bray, Strategies in the design of peptidoleukotriene antagonists, J. Lipid Mediators. 6(1-3): 265-73 (1993).
4. J.H. Musser, and A.F. Kreft, Substituted-[2-quinolinyl(bridged)aryl] compounds: modulators of eicosanoid biosynthesis and action, Drugs Future. 15: 73-80 (1990).
5. 4 receptor antagonist devoid of peroxisomal enzyme induction, Bioorg. Med. Chem. Lett. 5: 283-288 (1995).