Nitrergic transmission: Discovery and continuing studies

Asia Pacific Journal of Pharmacology

Volumn 12, Issue 3-4, 1997, Pages 137-148

  Rand, M J ^a   Li, C G ^a   La, M ^a   De Luca, A ^a   Najbar Kaszkiel, A ^a   Jiang, F ^a   Di Iulio, J ^a   Ellis, A ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Nitrergic; Nitric oxide; Nitric oxide synthase; Transmission; Transmitter

Indexed keywords

DUROQUINONE; HYDROQUINONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; QUINONE DERIVATIVE; SUPEROXIDE;

AUTONOMIC NERVOUS SYSTEM; BRAIN BLOOD VESSEL; CENTRAL NERVOUS SYSTEM; ENDOTHELIUM CELL; ENZYME LOCALIZATION; ILEOCECAL VALVE; INTESTINE INNERVATION; LOWER ESOPHAGUS SPHINCTER; MACROPHAGE; NEUROTRANSMISSION; PROSTATE; REVIEW; SMOOTH MUSCLE RELAXATION; VASODILATATION;

EID: 0031390775     PISSN: 02179687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Bhagat K, Vallance P. Nitric oxide 9 years on. Journal of the Royal Society of medicine 1996, 89: 667-73.
2. Van Helmont, J.B. Entry in: Encyclopaedia Britannica, 15th Edition (1992), Vol. 6.
3. Garrison FH. An Introduction to the History of Medicine (1929). Fourth Edition. Saunders, Philadelphia.
4. Brunton TL. On the use of nitrite of amyl in angina pectoris. Lancet 1867, ii, 97-8.
5. Ignarro LJ, Kadowitz PJ. Pharmacological and physiological role of cGMP in vascular smooth muscle relaxation. Annual Reviews of Pharmacology and Toxicology 1985; 25: 171-91.
6. Feelisch M, Noack E. Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase. European Journal of Pharmacology 1987; 139: 19-30.
7. Waldman SA, Murad F. Cyclic GMP synthesis and function. Pharmacological Reviews 1987; 39: 163-96.
8. Feelisch M, Noack E, Schroder H. Explanation of the discrepancy between the degree of organic nitrate decomposition, nitrite formation and guanylate cyclase stimulation. European Heart Journal 1987; 9: 57-62.
9. Furchgott RF, Zawadski JV The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
10. Moncada S, Palmer RMJ, Higgs EA. Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochemical Pharmacology 1989; 38: 1709-15.
11. Hibbs JB, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deaminase activity and imino nitrogen oxidation to nitrite. Science 1987; 235: 473-6.
12. Marietta MA. Nitric oxide: biosynthesis and biological significance. Trends in Biochemical Science 1989; 14: 488-92.
13. Stuehr DJ, Nathan CF. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. Journal of Experimental Medicine 1989; 169: 1543-55.
14. Nathan C. Nitric oxide as a secretary product of mammalian cells. Federation of the American Societies for Experimental biology Journal 1992; 6: 3051-64.
15. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacological Reviews 1991; 43: 109-42.
16. Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988; 336: 385-7.
17. Garthwaite J. (1991) Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends in Neuroscience 1991; 14: 60-7.
18. Feelisch M, Te Poel M, Zamora R, Deussen A, Moncada S. Understanding the controversy over the identity of EDRF. Nature 1994; 368: 62-5.
19. Thomas ME, Pearse AGE. The solitary active cells. Histochemical demonstration of damage-resistant nerve cells with TPN-diaphorase reaction. Acta Neuropathology 1964; 3: 238-49.
20. Hope BT, Michael GJ, Knigge KM, Vincent SR. Neuronal NADPH-diaphorase is a nitric oxide synthase. Proceedings of the National Academy of Sciences (USA) 1991; 88: 2811-4
21. Schmidt HHHW, Gange GD, Nakane M, Pollock JS, Miller MF, Murad F. (1992) Mapping of neuronal nitric oxide synthase in the rat suggests frequent colocalisation with NADPH-diaphorase but not with soluble guanylyl cyclase, a novel paraneuronal function for nitrinergic signal transduction. Journal of Histochemistry 1992; 40: 1439-56.
22. Saffery MJ, Hassell CJ, Hoyle CH, Belai A, Moss J, Schmidt HH, Frsterman U, Murad F, Burnstock G. (1992) Colocalisation of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurones. Neuroreport 1992; 3: 333-6.
23. Ward SM, Xue C, Shuttleworth W, Bredt DS, Snyder SH, Sanders KM. NADPH diaphorase and nitric oxide synthase colocalisation in enteric neurons of canine proximal colon. American Journal of Physiology 1992; 263: G277-84.
24. Matsumoto T, Nakane M, Pollock JS, Kuk JE, Frsterman U A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of tissue to fixative. Neuroscience Letters 1993; 155: 61-4.
25. Tracey WR, Nakane M, Pollock JS, Frsterman U. Nitric oxide syntheses in neuronal cells, macrophages and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity. Biochemical and Biophysical Research Communications 1993; 195: 1035-40.
26. Bredt DS, Hwang PM, Snyder SH. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 1990; 347: 768-70.
27. Forsterman U, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H. Nitric oxide synthase isozymes, characterisation, purification, molecular cloning and functions. Hypertension 1994; 23: 1121-31.
28. Gillespie JS. Searching for the non-adrenergic, non-cholinergic autonomic transmitter. In: Pharmacology (1987), ed. Rand MJ, Raper C. Amsterdam. Exerpta Medica; pp. 161-70.
29. Rand MJ, Li CG. Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Annual Reviews of Physiology 1995; 57: 659-82.
30. Rand MJ, Li CG. Nitric oxide in the autonomic and enteric nervous systems. In: Nitric Oxide in the Nervous System (1995). ed. Vincent SR. Academic Press, London, pp. 227-79.
31. Yuan SY, Brookes SJH, Costa M. Inhibitory and excitatory neurotransmission to the isolated guinea-pig lower esophageal sphincter. Proceedings of the Australian Neuroscience Society 1996; 7: 81.
32. Preiksaitis HG, Tremblay L, Diamant NE. Nitric oxide mediates inhibitory nerve effects in human esophagus and lower esophageal sphincter. Digestive Diseases and Sciences 1994; 39: 770-5.
33. Tøttrup A, Knudsen MA, Hanberg Serensen F, Glavind EB. Pharmacological identification of different inhibitory mediators involved in the innervation of the internal anal sphincter. British Journal of pharmacology 1995; 115: 158-62.
34. Story DF, De Luca A, Li CG, Rand MJ. Nitrergic transmission mediating relaxation responses of the lower oesophageal sphincter in the rat. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 1995; 2: 143.
35. Soediono P, Burnstock G. Contribution of ATP and nitric oxide to NANC inhibitory transmission in rat pyloric sphincter. British Journal Pharmacology 1994; 113: 681-6.
36. De Luca A, Rand MJ. Interaction of purinergic transmission with nitrergic mechanisms in the rat anal sphincter. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 1996; 3: 106.
37. Rand MJ, De Luca A. Apparent essential role of a neuronal-type nicotinic receptor in nitrergic transmission in the rat anal sphincter. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 1995; 2: 45.
38. Bowman WC. The Pharmacology of the Neuromuscular Function (1990). Wright, London.
39. Toda N. Nitric oxide and the regulation of cerebral arterial tone. In: Nitric Oxide in the Nervous System (1995) ed. Vincent SR. Academic Press, London, pp 207-25.
40. Jiang F, Li CG, Rand MJ. Mechanisms of electrical field stimulation-induced vasodilatation in the guinea-pig basilar artery: the role of endothelium. Journal of Autonomic Pharmacology 1997; in press.
41. Ayajiki K, Okamura T, Toda N. Neurogenic relaxations caused by nicotine in isolated cat middle cerebral arteries. Journal of Pharmacology and Experimental Therapeutics 1994; 270: 795-801.
42. Sienkiewicz W, Kaleczyc J, Majewski M, Lakomy M. NADPH-diaphorase-containing cerebrovascular nerve fibres and their possible origin in the pig. Journal Fur Himforschung 1995; 36: 353-63.
43. Barroso CP, Edvinsson L, Zhang W, Cunha-e-Sa M, Springall DR, Polak JM, Gulbenkian S. Nitroxidergic innervation of guinea-pig cerebral arteries. Journal of the Autonomic Nervous System 1996; 58: 108-14.
44. Matthew JD, Wadsworth RM. The role of nitric oxide in inhibitory neurotransmission in the middle cerebral artery of the sheep. General Pharmacology 1997; 28: 393-7.
45. Florence VM, Bevan JA. Biochemical determinations of cholinergic innervation in cerebral arteries. Circulation Research 1979; 45: 212-18.
46. Van Riper DA, Bevan JA. Electrical field stimulation-mediated relaxation of rabbit middle cerebral artery. Evidence of a cholinergic endothelium-dependent component. Circulation Research 1992; 70: 1104-12.
47. Lee, TJ-F, Sarwinski SJ. Nitric oxidergic neurogenic vasodilation in the porcine basilar artery. Blood Vessels 1991; 28: 407-12.
48. Toda N, Okamura T. Mechanism underlying the response to vasodilator nerve stimulation in isolated dog and monkey cerebral arteries. American Journal of Physiology 1990; 259: H1511-7.
49. Robertson BE, Schubert R, Hescheler J, Nelson MT. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. American Journal of Physiology 1993; 265(I Pt 1): C299-303.
50. Holland M, Standen NB, Boyle JP Nitric oxide activates large conductance potassium channels in rat cerebral artery smooth muscle cells. British Journal of Pharmacology 1996; 118 (Supplement): 106P.
51. Burnett, AL, Lowenstein, CJ, Bredt, DS, Chang, TS, Snyder, SH. Nitric oxide: a physiological mediator of penile erection. Science. 1992; 257: 401-3.
52. Burnett AL, Tillman SL, Chang TSK, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. Immunohistochemical localisation of nitric oxide synthase in the autonomic innervation of the human penis. Journal of urology. 1993, 150: 73-6.
53. Addicks K, Klotz T, Loch C, Schmidt U, Bloch W. Localization of nitric oxide synthase in the human prostate: histochemical and immunhistochemical study using light- and electronmicroscopical techniques. In: Biology of Nitric Oxide (1996), Part 5, ed. Moncada S, Stamler J, Gross S, Higgs EA. Portland Press, London, pp. 242.
54. Ehrén I, Adolfsson J, Wiklund NP. Nitric oxide synthase activity in the human urogenital tract. Urological Research 1994; 22: 287-90.
55. Ehrén I, Hammerström M, Adolfsson J, Wiklund NP Nitric oxide synthase activity in the urogenital tract. In: Biology of Nitric Oxide (1996), Part 5, ed. Moncada S, Stamler J, Gross S, Higgs EA. Portland Press, London, pp. 243.
56. Burnett AL, Maguire MP, Chamness SL, Ricker DD, Takeda M, Lepor H, Chang TSK. Characterisation and localisation of nitric oxide synthase in the human prostate. Urology 1995; 45: 435-9.
57. Di Iulio JL, Li CG, Falckh PHJ, Rand MJ. Characterisation of enzymes that convert L-arginine to L-citrulline in the rat prostate gland. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists 1996; 3: 111.
58. Aikawa K, Yamaguchi O, Yokota T, Shiraiwa Y. The involvement of the L-arginine/nitric oxide pathway in rabbit prostatic smooth muscle. Neurourology and Urodynamics 1994, 13: 399-400.
59. Takeda MMD, Tang RBS, Shapiro EMD, Lepor HMD. Effects of nitric oxide on human and canine prostates. Urology 1995; 45: 440-6.
60. Najbar-Kaszkiel AT, Li CG, Rand MJ. Characterisation of transmitter systems in isolated prostate glands of rats, guinea-pigs, pigs and rabbits. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists 1996; 3: 160.
61. Gillespie JS, Sheng H. The effects of pyrogallol and hydroquinone on the responses to NANC nerve stimulation in the rat anococcygeus and bovine retractor penis muscles. British Journal of pharmacology 1990; 99: 194-6.
62. De Man JG, De Winter BY, Boeckxstaens GE, Herman AG, Pelckmans PA. Effect of thiol modulators and Cu/Zn superoxide dismutase inhibition on nitrergic relaxations in the rat gastric fundus. British Journal of Pharmacology 1996; 119: 1022-8.
63. Barbier AJM, Lefebvre RA. Effect of LY 83583 on relaxation induced by non-adrenergic non-cholinergic nerve stimulation and exogenous NO in the rat gastric fundus. European Journal of Pharmacology 1992; 219: 331-4.
64. Lefebvre RA. Influence of superoxide dismutase inhibition on the discrimination between NO and the nitrergic transmitter in the rat gastric fundus. British Journal of Pharmacology 1996; 118: 2171-7.
65. Li, CG, Rand, MJ. Inhibition of NO-mediated responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. British Journal of Pharmacology. 1996; 118: 57-62.
66. Gibson A, Brave SR, Tucker JF. Differential effect of xanthine:xanthine oxidase on NANC and NO-induced relaxations of the mouse anococcygeus. Canadian Journal of Physiology and Pharmacology (Supplement 1) 1994; 475.
67. Martin W, McAllister KHM, Paisley K. NANC transmission in the bovine retractor penis is blocked by superoxide anion following inhibition of superoxide dismutase with diethyldithiocarbamate. Neuropharmacology 1995; 33: 1293-301.
68. Lilley E, Gibson A. Antioxidant protection of NO-induced relaxations of the mouse anococcygeus against inhibition by superoxide anioris, hydroquinone and carboxy-PTIO. British Journal of Pharmacology 1996; 119: 432-8.
69. Lilley E, Gibson A. Inhibition of relaxations to nitrergic stimulation in the mouse anococcygeus by duroquinone. British Journal Pharmacology 1995; 116: 3231-6.
70. Paisley K, Martin W. Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy-PTIO in bovine retractor penis: role of superoxide anion. British Journal Pharmacology 1996; 117: 1633-8.
71. Hobbs AJ, Tucker JF, Gibson A. Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle. British Journal of Pharmacology 1991; 104: 645-50.
72. Gillespie JS, Sheng H. (1989) A comparison of haemoglobin and erythrocytes as inhibitors of smooth muscle relaxation by the NANC transmitter in the BRP and rat anococcygeus and by EDRF in the rabbit aortic strip. British Journal of Pharmacology 1989; 98: 445-50.
73. Rand MJ, Li CG. Discrimination by the NO-trapping agent, carboxy PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. British Journal of Pharmacology 1995; 115: 1906-10.
74. La M, Li CG, Rand MJ. Comparison of the effects of hydroxocobalamin and oxyhaemoglobin on responses to NO, EDRF and the nitrergic transmitter. British Journal of Pharmacology 1996; 117: 805-10.
75. Jenkinson KM, Reid JJ, Rand MJ. Hydroxocobalamin and haemoglobin differentiate between exogenous and neuronal nitric oxide in the rat gastric fundus. European Journal of pharmacology 1995; 275: 145-52.
76. Rajanayagam MAS, Li CG, Rand MJ. Differential effects of hydroxocobalamin on NO- mediated relaxations is rat aorta and anococcygeus muscle British Journal of Pharmacology 1993; 108: 3-5.
77. Boeckxstaens GE, De Man JG, De Winter BY, Herman AG, Pelckmans PA. Pharmacological similarity between nitric oxide the and nitrergic transmitter in the canine ileocolonic junction. European Journal of Pharmacology 1994; 264: 85-9.
78. De Man JG, Boeckxstaens, GE, De Winter GE, Moreels, BY, Misset TG, Herman AG, Peickmans PA. Comparison of the pharmacological profile of S-nitrosothiols, nitric oxide and the nitrergic transmitter in the canine ileocolonic junction. British Journal of Pharmacology 1995; 114: 1179-4.