Factors to be considered for robust high-throughput automated dna sequencing using a multiple-capillary array instrument

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 2985, Issue , 1997, Pages 4-18

  Carrilho, Emanuel ^a   Miller, Arthur W ^a   Ruiz Martinez, Marie C ^a   Kotler, Lev ^a   Kesilman, Jeffrey ^a   Karger, Barry L ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Capillary array electrophoresis; CCD camera; Crosstalk subtraction; DNA sequencing; Fluorescence detection; Replaceable polymer solution

Indexed keywords

CAMERAS; CHARGE COUPLED DEVICES; CROSSTALK; DATA PROCESSING; DNA SEQUENCES; FLUORESCENCE; POLYMERS; SOLUTIONS;

MULTIPLE-CAPILLARY ARRAY INSTRUMENTS;

OPTICAL SYSTEMS;

EID: 0031371740     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.274344     Document Type: Conference Paper

References (20)

1. Complete genome sequence of the methanogenic archaeon, methanococcus jannaschii
2. 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans
3. Rapid separation and purification of oligonucleotides by high-performance capillary gel electrophoresis
4. Capillary array electrophoresis: An approach to high-speed, high-throughput DNA sequencing
5. Multiple sheath-flow gel capillary-array electrophoresis for multicolor fluorescent DNA detection
6. -1
7. Evaluation of the potential of a charge-injection device for DNA sequencing by multiplexed capillary electrophoresis
8. A capillary array gel electrophoresis system using multiple laser focusing for DNA sequencing
9. DNA sequencing by capillary electrophoresis with a hydroxyethylcellulose sieving buffer
10. DNA sequencing by capillary electrophoresis with replaceable linear polyacrylamide and laser-induced fluorescence detection
11. High speed DNA sequencing by using mixed poly(ethylene oxide) solutions in uncoated capillary columns
12. Rapid DNA sequencing of more than 1,000 bases per run by capillary electrophoresis using replaceable linear polyacrylamide solutions
13. Polyacrylamide solutions for DNA sequencing by capillary electrophoresis: Mesh sizes, separation and dispersion
14. Elimination of electroendosmosis and solute adsorption
15. Characterization and performance of a neutral hydrophilic coating for the capillary electrophoretic separation of biopolymers
16. DNA sequencing and analysis by multi-capillary electrophoresis using replaceable linear polyacrilamide
17. A graph-theoretic approach to the analysis of DNA sequencing data