Phase I clinical trial of cefditoren pivoxil (ME1207). Tolerance in healthy volunteers

Drugs under Experimental and Clinical Research

Volumn 23, Issue 3-4, 1997, Pages 131-138

  Li, J T ^a   Hou, F ^a   Lu, H ^a   Li, T Y ^a   Li, H ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CEFDITOREN PIVOXIL;

ABDOMINAL DISCOMFORT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG SAFETY; DRUG TOLERANCE; HEMATOLOGY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; URINALYSIS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; CEPHALOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; POSTPRANDIAL PERIOD;

EID: 0031371073     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Tamura A. et al. In vitro and in vivo antibacterial activities of ME1207, a new oral cephalosporin. Antimicrob. Agents Chemother., 32, 1421, 1988.
2. Arakawa S. et al. Clinical long-term studies for treatment of chronic complicated urinary tract infections. Jpn. J. Antibiot., 46, 75, 1993.
3. Pediatric Study Group of ME1207 (Chief investigator: Fujii R.). Pharmacokinetic and clinical studies of cefditoren pivoxil in the pediatric field. Jpn. J. Antibiot., 46, 95, 1993.
4. Saito A. Pharmacokinetics and tissue penetration of cefditoren pivoxil. In: Einhorn J. at al., eds. Recent Advances in Chemotherapy: Proceedings of the 18th International Congress of Chemotherapy, Stockholm, Sweden, 1993, p. 403.
5. Shiba K., et al. A double-blind comparative study of cefditoren pivoxil versus cefteram pivoxil in the treatment of bacterial pneumonia. In: Einhorn J. et al., eds. Recent Advances in Chemotherapy Proceedings of the 18th International Congress of Chemotherapy, Stockholm, Sweden, 1993, p. 35.
6. Arata J. et al. A double-blind comparative study of cefditoren pivoxil versus cefaclor in the treatment of skin structure infections. In: Einhorn J. et al., eds Recent Advances in Chemotherapy: Proceedings of the 18th International Congress of Chemotherapy, Stockholm, Sweden, 1993, p. 163.
7. Shimada K., Matsumoto T., Komiya I., Shinkai S. Phase I clinical studies on a novel oral cephem antibiotic. ME1207. Chemotherapy, 40(S-2), 105, 1992.