Inhibition of mammalian topoisomerase I by 1-nitro-9-aminoacridines. Dependence on thiol activation

Acta Biochimica Polonica

Volumn 44, Issue 4, 1997, Pages 775-780

  Ciesielska, Ewa ^a   Pastwa, Elzbieta ^a   Szmigiero, Leszek ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

1 Nitroacridines; Nitracrine; Topoisomerase I

Indexed keywords

MAMMALIA;

AMINOACRIDINE DERIVATIVE; DITHIOTHREITOL; DNA TOPOISOMERASE; ENZYME INHIBITOR;

ANIMAL; ARTICLE; DNA ADDUCT; DNA SUPERCOILING; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME STABILITY; ENZYMOLOGY; IN VITRO STUDY; LEUKEMIA L 1210; METABOLISM; MOUSE;

AMINOACRIDINES; ANIMALS; DITHIOTHREITOL; DNA ADDUCTS; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME STABILITY; LEUKEMIA L1210; MICE;

EID: 0031328626     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.1997_4381     Document Type: Article

References (11)

1. Gniazdowski, M. & Szmigiero, L. (1995) General Pharmacol. 26, 473-481.
2. Ciesielska, E. & Szmigiero, L. (1994) Acta Biochim. Polon. 41, 141-143.
3. Boege, F. (1996) Eur. Clin. Chem. Clin. Biochem. 34, 873-888.
4. Ciesielska, E., Szmigiero, L. & Gniazdowski, M. (1995) 5th International Symposium on Molecular Aspects of Chemotheraphy, Gdańsk, Poland, Abstract p.77.
5. Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D. & Mitchell, J.B. (1987) Cancer Res. 47, 936-942.
6. Hertzberg, R.P., Caranfa, M.J. & Hecht, S.M. (1989) Biochemistry 28, 4629-4638.
7. Ciesielska, E. & Szmigiero, L. (1996) Cell. & Molec. Biol. Lett. 1, 373-376.
8. Wilson, W.R., Denny, W.A., Stewart, G.M., Fenn, A. & Probert, J.C. (1986) Int. J. Rad. Oncol. Biol. Phys. 12, 1235-1238.
9. Denny, W.A., Atwell, G.J., Anderson, R.F. & Wilson, W.R. (1990) J. Med. Chem. 33, 1288-1295.
10. Wilson, W.R., Thompson, L.H., Anderson, R.F. & Denny, W.A. (1989) J. Med. Chem. 32, 31-38.
11. Pommier, Y., Covey, J.M., Kerrigan, D., Markovits, J. & Pham, R. (1987) Nucleic Acids Res. 15, 6713-6731.