Efficacy of alpha interferon in chronic hepatitis C patients non responder to a first treatment. A pilot prospective and randomized trial;Interet de l'interferon alpha a forte dose chez les malades atteints d'une hepatite virale chronique C non repondeurs a un premier traitement. Etude pilote prospective et randomisee

Gastroenterologie Clinique et Biologique

Volumn 21, Issue 12, 1997, Pages 924-928

  Rolachon, Alain ^a   Kézachian, Gilles ^a   Causse, Xavier ^b   Baud, Maryline ^c   Leroy, Vincent ^a,c   Maynard Muet, Marianne ^a   Pasquier, Dominique ^a   Zarski, Jean Pierre ^a,c  

^a HÔPITAL MICHALLON   (France)

^b CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

^c CNRS   (France)

Author keywords

Alpha interferon; Chronic hepatitis C; HCV RNA; Non responder; Treatment

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; ANTIVIRUS AGENT; VIRUS RNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HEPATITIS C; HISTOLOGY; HUMAN; LIVER NECROSIS; MALE; CLASSIFICATION; CLINICAL TRIAL; DOSE RESPONSE; GENETICS; GENOTYPE; HEPATITIS C VIRUS; LIVER; PATHOLOGY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIVIRAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2B; LIVER; MALE; PROSPECTIVE STUDIES; RNA, VIRAL;

EID: 0031325475     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Poynard T, Leroy V, Cohard M, Thevenot T, Mathurin P, Opolon P, et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C. Effects of dose and duration. Hepatology 1996; 24: 778-89.
2. Tiné F, Magrin S, Craxi A, Pagliaro L. Interferon for chronic non A non B hepatitis: a meta-analysis of randomized clinical trials. J Hepatol 1991; 13: 192-9.
3. Kobayashi Y, Watanabe S, Konishi M, Yokoi M, Kakehashi R, Kaito M, et al. Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatits C treated with Interferon beta. Hepatology 1993; 18: 1319-25.
4. Mita E, Hayashi N, Hagirawa H, Ueda K, Kanazawa Y, Kasahera A, et al. Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer. Dig Dis Sci 1994; 39: 977-82.
5. Tsubota A, Chayama K, Ikeda K, Yasuji A, Koida I, Saitoh S, et al. Factors predictive of response to interferon alpha therapy in hepatitis C virus infection. Hepatology 1994; 19: 1088-94.
6. Martinot-Peignoux M, Marcellin P, Pouteau M, Castelnau C, Boyer N, Poliquin M, et al. Pretreatment serum hepatitis C virus RNA levels and hepatitis C virus genotype are the main and independent prognostic factors of sustained response to interferon alpha therapy in chronic hepatitis C. Hepatology 1995; 22: 1050-6.
7. Brouwer JT, Kleter GEM, Elevaut A, Chamuleau RAFM, Michielsen P, Haetjink RA, et al. Initial non-responses to interferon in chronic hepatitis C: induction of ALT normalisation and HCV-RNA disappearance by high-dose interferon therapy (abstract). J Hepatol 1992; 16 (suppl. 1): S49.
8. Boyer N, Marcellin P, Goritsas C, Erlinger S, Bcnhamou JP. Efficacité du retraitement par Interféron alpha chez les malades atteints d'hépatite chronique C (résumé). Gastroenterol Clin Biol 1995; 19: 81.
9. Castillo I, Bartolomé J, Navas S, Gonzales S, Herrero M, Carreno V. Virological and biochemical long-term follow-up of patients with chronic hepatitis C treated with interferon. Hepatology 1994; 19: 1342-6.
10. Marcellin P, Pouteau M, Boyer N, Caslelnau C, Erlinger S, Benhamou JP. Retreatment with recombinant interferon alpha in patients with chronic hepatitis C. J Infect Dis 1993; 167: 780-1.
11. Marriott E, Quiroga JA, Carreno V. Retreatment of chronic hepatitis C with interferon alpha. J Infect Dis 1992; 166: 1200-1.
12. Toyoda H, Nakano S, Takeda I, Kumada T, Sugiyama K, Osada T, et al. Retreatment of chronic hepatitis C with interferon. Am J Gastroenterol 1994; 89: 1453-7.
13. Gerken G, Teuber G, Goergen B, Meyer KH. Interferon-alpha retreatment in chronic hepatitis C. J Hepatol 1995; 22 (suppl. 1): 118-21.
14. Bonkovsky HL, Clifford BD, Smith JL, Allan C, Banner B. High-dose interferon-a2b for retreatment of non-responders or relapsing patients with chronic hepatitis C. A controlled randomized trial. Dig Dis Sci 1996; 41: 149-54.
15. Chow WC, Marcellin P, Boyer N, Pouteau M, Castelnau C, Degos F, et al. Interferon retreatment in chronic hepatitis C (CHC) patients after a standard course of interferon therapy (abstract). Hepatology 1996; 24: 274.
16. Shibata M, Kumada T, Yamada M, Nakano S, KudaT, Monishima T. Effects of interferon on serum hepatitis C virus in patients with chronic hepatitis C. Dig Dis Sci 1993; 38: 608-11.