Comparison of the efficacy of two nucleosid analogues against FIV in naturally infected cats;Vergleichende Untersuchung über die Wirksamkeit zweier Nukleosidanaloga bei FIV-infizierten Katzen

Tierarztliche Praxis Ausgabe K: Kleintiere - Heimtiere

Volumn 25, Issue 6, 1997, Pages 671-677

  Kuffer, Manuela ^a   Baizarini, J ^b   Rolinski, B ^a   Goebel, F ^a   Erfle, V ^c   Goldberg, M ^a   Hartmann, Katrin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Antiviral chemotherapy; Cat; FIV; Nucleosid analogues

Indexed keywords

9 (3 FLUORO 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 9-(3-FLUORO-2-PHOSPHONYLMETHOXYPROPYL)ADENINE; ADEFOVIR; ADENINE; ANTIVIRUS AGENT; DRUG DERIVATIVE; ORGANOPHOSPHORUS COMPOUND; PHOSPHONIC ACID DERIVATIVE; PLACEBO;

ANIMAL; ARTICLE; CAT; CAT DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FELINE IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; CATS; DOUBLE-BLIND METHOD; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNODEFICIENCY VIRUS, FELINE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PLACEBOS; TREATMENT OUTCOME;

EID: 0031319922     PISSN: 14341239     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Baizarini J, Baba M, Pauwels R et al. Anti-retrovirus activity of 3′-fluoro- and 3′-azido-substituted pyrimidine 2′,3′-dideoxynucleoside analogues. Biochem Pharmacol 1988; 37: 2847-56.
2. Balzarini J, Sobis H, Naesens L et al. Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3′-azido-2′,3′-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus. Int J Cancer 1990; 46: 486-9.
3. Balzarini J, Holy A, Jindrich J et al. 9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Proc Natl Acad Sci USA 1991; 88: 4961-5.
4. Balzarini J, Naesens L, Slachmuylders J et al. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. AIDS 1991; 5: 21-8.
5. Brunner D, Pedersen NC. Infection of peritoneal macrophages in vitro and in vivo with feline immunodeficiency virus. J Virol 1989; 63: 5483-8.
6. Donath A. Einsatz der antilentiviral wirksamen Dideoxynukleoside Zidovudin (AZT) und Pnosphonylmethoxyadenin (PMEA) bei natürlich FIV-infizierten Katzen. Diss med vet, München 1992.
7. Egberink HF. FIV-infection: an animal model for AIDS. Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit te Utrecht, 1991.
8. Egberink HF, Borst M, Niphuis H et al. Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyDadenine. Proc Natl Acad Sci USA 1990; 87: 3087-91.
9. Foster SA, Cerny J, Cheng Y. Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyDadenine. J Biol Chemistry 1991; 266: 238-44.
10. Fuchs D, Unterweger B, Hausen A et al. Anti-HIV-1 antibodies and neopterin levels in parenteral drug addicts in the Austrian Tyrol. J Aquir Immune Defic Syndr 1988; 1: 65-6.
11. Hartmann K, Kuffer M, Kraft W. Modifikation des KarnofskyIndexes für die Katze zur Beurteilung der Lebensqualität und zur Therapiekontrolle. Tierärztl Prax 1997; 25: 540-2.
12. Hartmann K. Entwicklung eines Testsystems zur Erprobung neuer Medikamente gegen die FIV-Infektion der Katze als Modell für die Behandlung erworbener Immunschwächesyndrome. Habilitationsschrift, München 1995.
13. Hartmann K, Donath A, Beer B et al. Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms. Vet Immunol Immunopathol 1992; 35: 167-75.
14. Hartmann K, Goldberg M, Wilhelm N et al. Pteridine - Prognostische Marker bei Retrovirusinfektionen der Katze. DVG-Tagung Innere Medizin und Labordiagnostik, München, Deutschland, 3,-5.3, 1995.
15. + cell numbers in cats with naturally acquired feline immunodeficiency virus infection. J Virol 1992; 66:1484-8.
16. Huber C, Batchelor JR, Fuchs D et al. Immune response-associated production of neopterin. J Exp Med 1984, 160: 310-6.
17. Kern P, Rokos H, Dietrich M. Raised serum neopterin levels and imbalances of t-lymphocyte subsets in viral diseases, acquired immune deficiency and related lymphadenopathy syndromes. Biomed Pharmacother 1984; 38: 407-11.
18. North TW, Cronn RC, Remington KM et al. Characterization of reverse transcriptase from feline immunodeficiency virus. J Biol Chem 1990; 265: 5121-8.
19. Pedersen NC, Ho EW, Brown ML, Yamamoto JK. Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science 1987; 235: 790-3.
20. Rauer M. Nachweis und Quantifizierung des felinen Immundefizienz-Virus in naturlich infizierten Katzen mit Hilfe der Polymerase-Kettenreaktion. Diss med vet, München 1993.
21. Reddy MM, McKinley GF, Grieco MH. Evaluation of HIV p24 antigen, beta2-microglobulin, neopterin, soluble CD4, soluble CDS, and soluble interleukin-2 receptor levels in patients with AIDS or AIDS-related complex treated with 2′,3′-dideoxyinosine (DDI). J Clin Lab Anal 1991; 5: 396-8.
22. Vahlenkamp T. Untersuchungen zur Wirksamkeit antiviraler Mittel gegenüber der felinen Immunschwächevirus (FIV)-Infektion in In-vitro-Testsystemen und an experimentell FIV-infizierten Katzen. Diss med vet, München 1993.
23. Zangerle R, Fuchs D, Reibnegger G et al. Neopterin and the acute phase response in human immunodeficiency virus type 1 (HIV-1) infection. Pteridines 1992; 3: 167-70.