Chymotrypsin Inhibitors in Mosquitoes: Activity Profile During Development and After Blood Feeding

Archives of Insect Biochemistry and Physiology

Volumn 36, Issue 4, 1997, Pages 315-333

  Hörler, Emanuel ^a,b   Briegel, Hans ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b NONE   (Switzerland)

Author keywords

Aedes aegypti; Digestion; Life cycle; Serine proteinase inhibitors

Indexed keywords

AEDES AEGYPTI; ANOPHELES ALBIMANUS; BACTERIA (MICROORGANISMS); BOVINAE;

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CHYMOTRYPSIN; PROTEINASE; PROTEINASE INHIBITOR; TRYPSIN INHIBITOR;

AEDES; ANIMAL; ANOPHELES; ARTICLE; CATTLE; CHEMISTRY; CULEX; DRUG ANTAGONISM; FEEDING BEHAVIOR; FEMALE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOSQUITO;

AEDES; ANIMALS; ANOPHELES; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; CATTLE; CHYMOTRYPSIN; CULEX; CULICIDAE; ENDOPEPTIDASES; FEEDING BEHAVIOR; FEMALE; PROTEASE INHIBITORS; TRYPSIN INHIBITORS;

EID: 0031309516     PISSN: 07394462     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6327(1997)36:4<315::AID-ARCH5>3.0.CO;2-Q     Document Type: Article

References (38)

1. Boigegrain RA, Mattras H, Brehélin M, Paroutaud P, Coletti-Previero MA (1992): Insect immunity: Two proteinase inhibitors from hemolymph of Locusta migratoria. Biochem Biophys Res Commun 189:790-793.
2. Borovsky D (1986): Proteolytic enzymes and blood digestion in the mosquito, Culex nigripalpus. Arch Insect Biochem Physiol 3:147-160.
3. Borovsky D, Schlein Y (1988): Quantitative determination of trypsinlike and chymotrypsinlike enzymes in insects. Arch Insect Biochem Physiol 8:249-260.
4. Brehélin M, Boigegrain RA, Drif L, Coletti-Previero MA (1991): Purification of a protease inhibitor which controls phenoloxidase activation in hemolymph of Locusta migratoria. Biochem Biophys Res Commun 179:841-846.
5. Briegel H (1969): Untersuchungen zum Aminosäuren- und Proteinstoffwechsel während der autogenen und anautogenen Eireifung von Culex pipiens. J Insect Physiol 15:1137-1166.
6. Briegel H (1990b): Metabolic relationship between female body size, reserves, and fecundity of Aedes aegypti. J Insect Physiol 36:165-172.
7. Briegel H (1990a): Fecundity, metabolism, and body size in Anopheles (Diptera: Culicidae), vectors of malaria. J Med Entomol 27:839-850.
8. Briegel H, Hörler E (1993): Multiple blood meals as a reproductive strategy in Anopheles (Diptera: Culicidae). J Med Entomol 30:975-985.
9. Briegel H, Lea AO (1975): Relationship between protein and proteolytic activity in the midgut of mosquitoes. J Insect Physiol 21:1597-1604.
10. Chasan R, Anderson KV (1989): The role of easter, an apparent serine protease in organizing the dorsal-ventral pattern of the Drosophila embryo. Cell 56:391-400.
11. Eguchi M, Matsui Y, Matsumoto T (1986): Developmental change and hormonal control of chymotrypsin inhibitors in the haemolymph of the silkworm, Bombyx mori. Comp Biochem Physiol 84B:327-332.
12. Erlanger BF, Edel F, Cooper AG (1966): The action of chymotrypsin on two new chromogenic substrates. Arch Biochem Biophys 115:206-210.
13. Graf R, Briegel H (1982): Comparison between aminopeptidase and trypsin activity in blood-fed females of Aedes aegypti. Rev Suisse Zool 89:845-850.
14. Graf R, Briegel H (1989): The synthetic pathway of trypsin in the mosquito Aedes aegypti (L.) (Diptera: Culicidae) and in vitro stimulation in isolated midguts. Insect Biochem 19:129-137.
15. Hörler E, Briegel H (1995): Proteolytic enzymes of female Anopheles: Biphasic synthesis, regulation, and multiple feeding. Arch Insect Biochem Physiol 28:189-205.
16. Hummel BCW (1959): A modified spectrophotometric determination of chymotrypsin, trypsin and thrombin. Can J Biochem Physiol 37:1393-1399.
17. Kang SH, Fuchs MS (1973): An improvement in the Hummel chymotrypsin assay. Anal Biochem 54:262-265.
18. Kromer E. Nakakura N, Lageux M (1994): Cloning of a Locusta cDNA encoding precursor peptide for structurally related proteinase inhibitors. Insect Biochem Mol Biol 24:329-331.
19. Laskowski M Jr, Kato I (1980): Protein inhibitors of proteinase. Ann Rev Biochem 49:593-626.
20. Li J, Christensen BM (1993): Involvement of L-tyrosine and phenoloxidase in the tanning of Aedes aegypti eggs. Insect Biochem Mol Biol 23:739-748.
21. Li J, Tracy JW, Christensen BM (1989): Hemocyte monophenol oxidase activity in mosquitoes exposed to microfilariae of Dirofilaria immitis. J Parasitol 75:1-5.
22. Masler EP, Whisenton LR, Schlaeger DA, Kang S, Fuchs MS (1983): Chymotrypsin and trypsin levels in adult Aedes atropalpus and Toxorhynchites brevipalpis (Theobald). Comp Biochem Physiol 756:435-440.
23. Morisato D, Anderson KV (1994): The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76:677-688.
24. Nakakura N, Hietter H, van Dorssellaer A, Luu B (1992): Isolation and structural determination of three peptides from the insect Locusta migratoria. Eur J Biochem 204:147-153.
25. Pellegrini A, Hägeli G, Fretz D, von Fellenberg R (1984): Natural protease inhibitors: Qualitative and quantitative assay by fibrinogen-agarose electrophoresis. Anal Biochem 138:335-339.
26. Pellegrini A, Thomas U, von Fellenberg R, Wild P (1992): Bactericidal activities of lysozyme and aprotinin against gram-negative and gram-positive bacteria related to their basic character. J Appl Bacteriol 72:180-187.
27. Pino-Heiss S, Schubiger G (1989): Extracellular protease production by Drosophila imaginal discs. Dev Biol 132:282-291.
28. Ramesh N, Sugumaran M, Mole JE (1988): Purification and characterization of two trypsin inhibitors from the hemolymph of Manduca sexta larvae. J Biol Chem 263:11523-11527.
29. Ryan CA (1974): Wound-induced accumulation of proteinase inhibitor I in tomato leaves. In Bayer-Symposium V. Fritz H, Tschesche H, Greene LJ, Truscheit E (eds), Springer-Verlag Berlin-Heidelberg-New York, pp 667-673.
30. Schoellmann G, Shaw E (1963): Direct evidence for the presence of histidine in the active center of chymotrypsin. Biochemistry 2:252-255.
31. Shaw E, Mares-Guia M, Cohen W (1965): Evidence for an active-center histidine in trypsin through use of a specific reagent, 1-chloro-3-tosylamido-7-amino-2-heptanone, the chloromethyl ketone derived from N-tosyl-L-lysine. Biochemistry 4:2219-2224.
32. Spiro-Kern A (1974): Untersuchungen über die Proteasen bei Culex pipiens. J Comp Physiol 90:53-70.
33. Spiro-Kern A, Chen PS (1977): Isolation of a chymotrypsin inhibitor form Culex pipiens by affinity chromatography. Insect Biochem 7:453-457.
34. Sugumaran M, Saul SJ, Ramesh N (1985): Endogenous protease inhibitors prevent undesired activation of prophenolase in insect hemolymph. Biochem Biophys Res Comm 132:1124-1129.
35. Travis J, Salvesen GS (1983): Human plasma proteinase inhibitors. Ann Rev Biochem 52:655-709.
36. Yang YJ, Davies DM (1971): Trypsin and chymotrypsin during metamorphosis in Aedes aegypti and properties of the chymotrypsin. J Insect Physiol 17:117-131.
37. Yang YJ, Davies DM (1972): A mosquito-chymotrypsin inhibitor in tissues of adult Aedes aegypti. Comp Biochem Physiol 43B:137-141.
38. Yoshida H, Yamashita M, Yonehara S, Eguchi M (1990): Properties of fungal protease inhibitors from the integument and hemolymph of the silkworm and effect of an inhibitor on the fungal growth. Comp Biochem Physiol 95B:559-564.