Functional role of β2-adrenoceptors in the transplanted heart

Journal of Cardiovascular Pharmacology

Volumn 30, Issue 6, 1997, Pages 811-816

  Hakim, Kavous ^a   Fischer, Martin ^a   Günnicker, Michael ^b   Poenicke, Klaus ^a   Zerkowski, Hans Reinhard ^a   Brodde, Otto Erich ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b University School of Medicine   (Germany)

Author keywords

2 adrenoceptors; Heart transplant; Isoprenaline; Sinus nodes

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BISOPROLOL; ISOPRENALINE; RECEPTOR SUBTYPE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CATECHOLAMINE;

ADULT; ARTICLE; AUTONOMIC DENERVATION; CLINICAL ARTICLE; DOSE RESPONSE; DRUG BLOOD LEVEL; HEART RATE; HEART TRANSPLANTATION; HUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; SINUS NODE; TACHYCARDIA; VAGUS NERVE STIMULATION; BLOOD; DRUG EFFECT; HEART; INNERVATION; MIDDLE AGED; PHYSIOLOGY; RADIOGRAPHY;

ADRENERGIC BETA-AGONISTS; BISOPROLOL; CATECHOLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HEART RATE; HEART TRANSPLANTATION; HUMANS; ISOPROTERENOL; MIDDLE AGED; RECEPTORS, ADRENERGIC, BETA-2; SINOATRIAL NODE;

EID: 0031308931     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199712000-00017     Document Type: Article

References (31)

1. Cannom DS, Graham AF, Harrison DC. Electrophysiological studies in the denervated transplanted human heart. Circ Res 1973; 32:268-78.
2. Mason JW, Harrison DC, Stinson EB. Autonomic nervous system and arrhythmias: studies in the transplanted denervated human heart. Cardiology 1976;61:75-87.
3. Regitz V, Bossaller C, Strasser R, Schüler S, Hetzer R, Fleck E. Myocardial catecholamine content after heart transplantation. Circulation 1990;82:620-3.
4. Bristow MR. The surgically denervated, transplanted human heart. Circulation 1990;82:658-60.
5. Banner NR, Yacoub MH. Physiology of the orthotopic cardiac transplant recipient. Semin Thorac Cardiovasc Surg 1990;2:259-70.
6. Lefkowitz RJ, Caron MG. Adrenergic-receptors: molecular mechanisms of clinically relevant regulation. Clin Res 1985;33:395-406.
7. Crick SJ, Wharton J, Sheppard MN, et al. Innervation of the human cardiac conduction system. A quantitative immunohistochemical and histochemical study. Circulation 1994;89:1697-708.
8. 2-adrenoceptors with increasing posttransplant time. Naunyn Schmiedebergs Arch Pharmacol 1991;344:430-6.
9. Denniss AR, Marsh JD, Quigg RJ, Gordon JB, Colucci WS. β-Adrenergic-receptor number and adenylate cyclase function in denervated transplanted and cardiomyopathic human hearts. Circulation 1989;79:1028-34.
10. Gilbert EM, Eiswirth CC, Mealey PC, Larrabee P, Herrick CM, Bristow MR. β-Adrenergic supersensitivity of the transplanted human heart is presynaptic in origin. Circulation 1989;79:344-9.
11. Cruz Caturla M, Masotti M, Brodde O-E, et al. Development of myocardial β-adrenoceptor density and adenylate cyclase activity after human heart transplantation. J Heart Lung Transplant 1992; 11:1059-65.
12. 2-adrenoceptors in long-term follow-up after orthotopic cardiac Transplantation. J Mol Cell Cardiol 1992;24:1189-98.
13. 2-adrenergic receptors in previously transplanted, denervated non-failing human hearts. J Am Coll Cardiol 1993;22:1902-8.
14. 2-Adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure. Pharmacol Rev 1991;43:203-42.
15. 1-adrenoceptor antagonist: in vitro and in vivo studies. J Cardiovasc Pharmacol 1986;8(suppl 11):S29-35.
16. Schäfers RF, Poller U, Pönicke K, et al. Influence of adrenoceptor and muscarinic receptor blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by tyramine. Naunyn Schmiedebergs Arch Phannacol 1997;355:239-49.
17. 2-adrenoceptor-mediated effects in humans. Am J Physiol 1988;254:H199-206.
18. 2-adrenoceptors: abnormality in essential hypertension and its correction by antihypertensives. Clin Pharmacol Ther 1987;41:371-9.
19. 2-adrenoceptors in the human heart: in vitro and in vivo studies. Am Heart J 1990;119:608-19.
20. 2-receptor mediated? N Engl J Med 1985;312:123-4.
21. Vincent HH, Boomsma F, Man in't Veld AJ, Derkx FHM, Wenting GJ, Schalekamp MADH. Effects of selective and nonselective β-agonists on plasma potassium and norepinephrine. J Cardiovasc Pharmacol 1984;6:107-14.
22. 1-adrenoceptor antagonist treatment. J Am Coll Cardiol 1994;23:1224-33.
23. McDevitt DG. In vivo studies on the function of cardiac β-adrenoceptors in man. Eur Heart J 1989;10(suppl B):22-8.
24. Von Scheldt W, Böhm M, Schneider B, Reichart B, Erdmann E, Autenrieth G. Isolated presynaptic inotropic β-adrenergic supersensitivity of the transplanted human heart in vivo. Circulation 1992;85:1056-63.
25. 2-receptors in cardiac responses to exercise in cardiac transplant patients. Circulation 1995;91:685-90.
26. Brown L, Deighton NM, Bals S, et al. Spare receptors for β-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart. J Cardiovasc Pharmacol 1992;19:222-32.
27. Arnold JMO, McDevitt DG. Vagal activity is increased during intravenous isoprenaline infusion in man. Br J Clin Pharmacol 1984;18:311-6.
28. Huang M-H, Friend DS, Sunday ME, et al. An intrinsic adrenergic system in mammalian heart. J Clin Invest 1996;98:1298-303.
29. 2-receptor stimulation by circulating epinephrine. N Engl J Med 1983;309:1414-9.
30. Leenen FHH, Chan YK, Smith DL, Reeves RA. Epinephrine and left ventricular function in humans: effects of beta-1 vs nonselective beta-blockade. Clin Pharmacol Ther 1988,43:519-28.
31. Daul A, Hermes U, Schäfers RF, Wenzel R, Von Birgelen C, Brodde O-E. The β-adrenoceptor subtype(s) mediating adrenaline- and dobutamine-induced blood pressure and heart rate changes in healthy volunteers. Int J Clin Pharmacol Ther 1995;33:140-8.