Treatment of bullous pemphigoid with low-dose methotrexate;Behandlung des bullosen pemphigoids mit low-dose-methotrexat

Hautarzt

Volumn 48, Issue 12, 1997, Pages 910-914

  Böhm, Ingrid ^a,b   Bauer, Ralf ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Bullous pemphigoid; Glucocorticosteroids; Immunomodulation; Immunsuppression; Methotrexat e

Indexed keywords

BASEMENT MEMBRANE ANTIBODY; CORTICOSTEROID; METHOTREXATE; DERMATOLOGICAL AGENT;

AGED; ARTICLE; CASE REPORT; DOSE RESPONSE; HUMAN; IMMUNOMODULATION; PEMPHIGOID; TOPICAL DRUG ADMINISTRATION; BULLOUS PEMPHIGOID; DRUG COMBINATION; FEMALE; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ADMINISTRATION, TOPICAL; ADRENAL CORTEX HORMONES; AGED; DERMATOLOGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; METHOTREXATE; PEMPHIGOID, BULLOUS;

EID: 0031307227     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001050050684     Document Type: Article

References (24)

1. Adam BA (1992) Bullous diseases in Malaysia: epidemiology and natural history. Int J Dermatol 31:42-45
2. al-Awadhi A, Dale P, McKendry RJ (1993) Pancytopenia associated with low dose methotrexate therapy. A regional survey. J Rheumatol 20:1121-1125
3. Appelhans M, Bonsmann G, Orge C, Bröcker EB (1993) Dexamethason-Cyclophosphamid-Stoßtherapie bei blasenbildenden Autoimmundermatosen. Hautarzt 44:143-147
4. Barrera P, Boerbooms AMT, Janssen EM, Sauerwein RW, Gallati H, Mulder J, de Boo T, Demacker PNM, Putte LBA van de, Meer JWM van der (1993) Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor α, and interleukin-6 levels in rheumatoid arthritis. Arthritis Rheum 36:1070-1079
5. Brody M, Böhm I, Bauer R (1993) Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1β to the interleukin 1 receptor on target cells. Eur J Clin Chem Clin Biochem 31:667-674
6. Burton JL, Greaves MW (1974) Azathioprine for pemphigus and pemphigoid. Br J Deramtol 91:103-109
7. Curley RK, Holden CA (1991) Steroid-resistent bullous pemphigoid treated with cyclosporin A. Clin Exp Dermatol 16:68-69
8. Czech W, Schaller J, Schöpf E, Kapp A (1993) Granulocyte activation in bullous diseases: release of granular proteins in bullous pemphigoid and pemphigus vulgaris. J Am Acad Dermatol 29:210-215
9. Ebisawa M, Bochner BS, Georas SN, Schleimer RP (1992) Eosinophil transendothelial migration induced by cytokines. J Immunol 149:4021-4028
10. Gallo R, Parodi A, Rebora A (1993) Pemphigoid nodularis. Br J Dermatol 129:744-745
11. Goerz G, Merk H (1981) Medikamentöse Immunsuppression in der Dermatologie. Z Hautkr 56:975-990
12. Grando SA, Glukhenky BT, Drannik GN, Epshtein EV, Kostromin AP, Korostash TA (1989) Mediators of inflammation in blister fluids from patients with pemphigus vulgaris and bullous pemphigoid. Arch Dermatol 125:925-930
13. Gruber GG, Owen LG, Callen JP (1980) Vesicular pemphigoid. J Am Acad Dermatol 3:619-622
14. Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR (1991) Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol 147:117-123
15. Martinez-Osuna P, Zwolinska JB, Sikes DH, Cory JG, Silveira LH, Jara LJ, Espinoza LR (1993) Lack of immunosuppressive effect of low-dose oral methotrexate on lymphocytes in rheumatoid arthritis. Clin Exp Rheumatol 11:249-253
16. Nishioka K, Hashimoto K, Katayama I, Sarashi C, Kubo T, Sano S (1984) Eosinophilic spongiosis in bullous pemphigoid. Arch Dermatol 120:1166-1168
17. Patterson JW, Ali M, Murray JC, Hazra TA (1985) Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy. Int J Dermatol 24:173-176
18. Paul MA, Jorizzo JL, Fleischer AB, White WL (1994) Low-dose methotrexate treatment in elderly patients with bullous pemphigoid. J Am Acad Dermatol 31:620-625
19. Schaumburg-Lever G (1985) Die Therapie des Pemphigus und Pemphigoids. Z Hautkr 61:811-812
20. Segal R, Mozes E, Yaron M, Tartakovsky B (1989) The effect of methotrexate on the production and activity of interleukin-1. Arthritis Rheum 32:370-377
21. Singh Y, Sharma M, Singh RR, Kumar A, Malaviya R, Malaviya AN (1992) Methotrexate: clinical and immunological effects in refractory rheumatoid arthritis. J Assoc Physicans India 40:658-661
22. Thivolet J, Barthelemy H, Rigot-Muller G, Bendelac A (1985) Effects of cyclosporin on bullous pemphigoid and pemphigus. Lancet 1:334-335
23. Thomas R, Carroll GJ (1993) Reduction of leukocyte and interleukin-1 beta concentration in the synovial fluid of rheumatoid arthritis patients treated with methotrexate. Arthritis Rheum 36:1244-1252
24. Wever S, Rank C, Hornschuh B, Hashimoto T, Nishikawa T, Bröcker EB, Zillikens D (1995) Bullöses Pemphigoid unter dem Bild einer Prurigo simplex subacuta. Hautarzt 46:789-795