The present status in the clinical development of MR contrast media;Gegenwartiger stand der klinischen entwicklung von MR-kontrastmitteln

RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren

Volumn 167, Issue 6, 1997, Pages 541-550

  Laniado, M ^a   Kopp, A F ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b NONE

Author keywords

Contrast media; Gadolinium; Iron; Magnetic resonance (MR), contrast enhancement; Manganese; State of art reviews

Indexed keywords

CONTRAST MEDIUM; GADODIAMIDE; GADOLINIUM; GADOLINIUM PENTETATE; GADOTERIC ACID; GADOTERIDOL; MANGAFODIPIR; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; EDETIC ACID; GADOLINIUM DO3A BUTRIOL; GADOLINIUM-DO3A-BUTRIOL; GADOTERATE MEGLUMINE; HETEROCYCLIC COMPOUND; IRON; MANGANESE; MEGLUMINE; N,N' BIS(PYRIDOXAL 5 PHOSPHATE)ETHYLENEDIAMINE N,N' DIACETIC ACID; N,N'-BIS(PYRIDOXAL-5-PHOSPHATE)ETHYLENEDIAMINE-N,N'-DIACETIC ACID; ORGANOMETALLIC COMPOUND; OXIDE; PYRIDOXAL 5 PHOSPHATE; SUPERPARAMAGNETIC IRON OXIDE;

COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC IMAGING; LYMPHOGRAPHY; MAGNETIC RESONANCE ANGIOGRAPHY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; REVIEW; ADULT; COMPARATIVE STUDY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; SUSPENSION;

ADULT; CLINICAL TRIALS, PHASE I; CLINICAL TRIALS, PHASE II; CLINICAL TRIALS, PHASE III; CONTRAST MEDIA; EDETIC ACID; GADOLINIUM; GADOLINIUM DTPA; HETEROCYCLIC COMPOUNDS; HUMANS; INJECTIONS, INTRAVENOUS; IRON; LYMPHOGRAPHY; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MANGANESE; MEGLUMINE; ORGANOMETALLIC COMPOUNDS; OXIDES; PYRIDOXAL PHOSPHATE; SUSPENSIONS;

EID: 0031306966     PISSN: 09366652     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Anzai, Y., K. E. Blackwell, S. L. Hirschowitz, J. W. Rogers, Y. Sato, W. T. Yuh, V. M. Runge, M. R. Morris, S. J. McLachlan, R. B. Lufkin: Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. Radiology 192 (1994) 709-715
2. Anzai, Y., S. McLachlan, M. Morris, R. Saxton, R. B. Lufkin: Dextran-coated superparamagnetic iron oxide, an MR contrast agent for assessing lymph nodes in the head and neck. Amer. J. Neuroradiol. 15 (1994) 87-94
3. Anzai, Y., M. R. Prince: Iron-oxide-enhanced MR lymphography: the evaluation of cervical lymph node metastases in head and neck cancer. J. Magn. Reson. Imag. 7 (1997) 75-81
4. Anzai, Y., M. R. Prince, J. H. Chenevert, J. H. Maki, F. Londy, M. London, S. J. McLachlan: MR angiography with an ultrasmall superparamagnetic iron oxide blood pool agent. J. Magn. Reson. Imag. 7 (1997) 209-214
5. Balzarini, L., S. Aime, L. Barbero, E. Ceglia, R. Petrillo, J. Reyner, J. D. Tesoro-Tess, R. Musumeci: Magnetic resonance imaging of the gastrointestinal tract: investigation of baby milk as a low cost contrast medium. Eur. J. Radiol. 15 (1992) 171-174
6. Bellin, M. F., S. Zaim, E. Auberton, G. Sarfati, J. J. Duron, D. Khayat, J. Grellet: Liver metastases: safety and efficacy of detection with superparamagnetic iron oxide in MR imaging. Radiology 193 (1994) 657-663
7. Bernardino, M. E., J. C. Weinreb, D. G. Mitchell, W. C. Small, M. Morris: Safety and optimum concentration of a manganese chloride-based oral MR contrast agent. J. Magn. Reson. Imag. 4 (1994) 872-876
8. Bernardino, M. E., S. W. Young, J. K. Lee, J. C. Weinreb: Hepatic MR imaging with Mn-DPDP: safety, image quality, and sensitivity. Radiology 183 (1992) 53-58
9. Bousquet, J. C., S. Saini, D. D. Stark, P. F. Hahn, M. Nigam, J. Wittenberg, J. T. Ferrucci: Gd-DOTA: characterization of a new paramagnetic complex. Radiology 166 (1988) 693-698
10. Brasch, R. C: New directions in the development of MR imaging contrast media. Radiology 183 (1992) 1-11
11. Caudana, R., G. Morana, G. P. Pirovano, N. Nicoli, A. Portuese, A. Spinazzi, R. Di Rito, G. F. Pistolesi: Focal malignant hepatic lesions: MR imaging enhanced with gadolinium benzylpropionictetra-acetat (BOPTA) - preliminary results of phase II clinical application. Radiology 199 (1996) 513-520
12. Dennie, J., A. G. Sorensen, R. M. Weisskoff: Hemodynamic imaging with Dy-DTPA-BMA in humans: direct comparison with Gd-chelates. Proceedings of International Society for Magnetic Resonance in Medicine, 4th Scientific Meeting. San Francisco. Society of Magnetic Resonance (1996) 1716 (Abstract)
13. Denys, A., L. Arrive, V. Servois: Hepatic tumors: detection and characterization at 1-T MR imaging enhanced with AMI-25. Radiology 193 (1994) 665-669
14. Dravid, V. S., M. J. Shapiro, D. G. Mitchell, E. K. Outwater, C. W. Piccoli, R. I. Feld, R. J. Wechsler, F. E. Rosato: MR portography: preliminary comparison with CT portography and conventional MR imaging. J. Magn. Reson. Imag. 4 (1994) 767-771
15. Duda, S. H., M. Laniado, A. F. Kopp, E. F. Grönewäller, K. P. Aicher, P. Pavone, E. Jehle, C. D. Claussen: Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging. J. Magn. Reson. Imag. 4 (1994) 309-314
16. Duda, S. H., M. Laniado, A. F. Kopp, E. F. Grönewäller, K. P. Aicher, P. Pavone, E. Jehle, C. D. Claussen: MR-Tomographie fokaler Leberläsionen mit dem superparamagnetischen Kontrastmittel AMI-25 bei 1,5 Tesla. Fortschr. Röntgenstr. 160 (1994) 46-51
17. Elizondo, G., C. J. Fretz, D. D. Stark, S. M. Rocklage, S. C. Quay, D. Worah, Y. M. Tsang, M. Chen, J. T. Ferrucci: Preclinical evaluation of Mn-DPDP: new paramagnetic hepatobiliary contrast agent for MR imaging. Radiology 178 (1991) 73-78
18. Felix, R., A. Heshiki, N. Hosten, H. Hricak: Magnevist: Eine Monographie. Blackwell, Berlin (1997)
19. Ferrucci, J. T., D. D. Stark: Iron oxide-enhanced MR imaging of the liver and spleen: review of the first 5 years. Amer. J. Roentgenol. 155 (1990) 943-950
20. Gallez, B., C. Baudelet, J. Adline, V. Charbon, D. M. Lambert: The uptake of Mn-DPDP by hepatocytes is not mediated by the facilitated transport of pyridoxine. Magn. Reson. Imaging 14 (1996)1191-1195
21. Gandon, Y., J. F. Heautot, F. Brunet, D. Guyader, Y. Deugnier, M. Carsin: Superparamagnetic iron oxide: clinical time-response study. Eur. J. Radiol. 12 (1991) 195-200
22. Gehl, H. B., R. Urhahn, K. Bohndorf, P. Klever, S. Hauptmann, K. P. Lodemann, S. Matern, V. Schumpelick, R. W. Günther: Mn-DPDP in MR imaging of pancreatic adenocarcinoma: initial clinical experience. Radiology 186 (1993) 795-798
23. Gehl, H. B., D. Vorwerk, K. C. Klose, R. W. Günther: Pancreatic enhancement after low-dose infusion of Mn-DPDP. Radiology 180 (1991) 337-339
24. Grandin, C., B. E. Van Beers, A. Robert, J. F. Gigot, A. Geubel, J. Pringot: Benign hepatocellular tumors: MRI after superparamagnetic iron oxide administration. J. Comput. Assist. Tomogr. 19 (1995) 412-418
25. 1-weighted MR SE images by superparamagnetic iron oxide particles. J. Comput. Assist. Tomogr. 18 (1994) 888-896
26. Grant, D., K. Zech, E. Holtz: Biodistribution and in vivo stability of manganese dipyridoxyl diphosphate in relation to imaging efficacy. Invest. Radiol. 29 (1994)
27. Hagspiel, K. D., K. F. Neidl, A. C. Eichenberger, W. Weder, B. Marincek: Detection of liver metastases: comparison of superparamagnetic iron oxide-enhanced and unenhanced MR imaging at 1.5T with dynamic CT, intraoperative US, and percutaneous US. Radiology 196 (1995) 471-478
28. Hahn, P. F., D. D. Stark, J. M. Lewis, S. Saini, G. Elizondo, R. Weissleder, C. J. Fretz, J. T. Ferrucci: First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging. Radiology 175 (1990) 695-700
29. Hahn, P. F., D. D. Stark, R. Weissleder, G. Elizondo, S. Saini, J. T. Ferrucci: Clinical application of superparamagnetic iron oxide to MR imaging of tissue perfusion in vascular liver tumors. Radiology 174 (1990) 361-366
30. Hamm, B., A. M. Bassi, L. Grazioli, R. Manfredi, J. W. C. Gratama, G. Marchal, T. McNamara, M. Reiser, M. Laniado, E. Rummeny, G. Pirovano, S. Ceriati, P. Pianezzoli, A. Spinazzi: Multi-Hance-enhanced dynamic and delayed MR imaging in the detection and characterization of focal liver lesions. International Society of Magnetic Resonance in Medicine, 5th Scientific Meeting, 12-18.4.1997, Vancouver
31. Hamm, B., M. Reichel, T. Vogl, M. Taupitz, K. J. Wolf: Superparamagnetische Eisenpartikel. Klinische Ergebnisse in der MR-Diagnostik von Lebermetastasen. Fortschr. Röntgenstr. 160 (1994) 52-58
32. Hamm, B., T. Staks, A. Muhler, M. Bollow, M. Taupitz, T. Frenzel, K. J. Wolf, H. J. Weinmann, L. Lange: Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 195 (1995) 785-792
33. Hamm, B., T. Staks, M. Taupitz, R. Maibauer, A. Speidel, A. Huppertz, T. Frenzel, R. Lawaczeck, K. J. Wolf, L. Lange: Contrast-enhanced MR imaging of liver and spleen: first experience in humans with a new superparamagnetic iron oxide. J. Magn. Reson. Imag. 4 (1994) 659-668
34. Hamm, B., T. J. Vogl, G. Branding, B. Schnell, M. Taupitz, K. J. Wolf, J. Lissner: Focal liver lesions: MR imaging with Mn-DPDP. Initial clinical results in 40 patients. Radiology 182 (1992) 167-174
35. Harisinghani, M. G., S. Saini, G. J. Slater, M. D. Schnall, M. D. Rifkin: MR imaging of pelvic lymph node in primary pelvic carcinoma with ultrasmall superparamagnetic iron oxide (Combidex): preliminary observations. J. Magn. Reson. Imag. (1997) 161-163
36. Harisinghani, M. G., S. Saini, R. Weissleder, E. F. Halpern, W. Schima, D. L. Rubin, A. E. Stillman, G. T. Sica, W. C. Small, P. F. Hahn: Differentiation of liver hemangiomas from metastases and hepatocellular carcinoma at MR imaging enhanced with blood-pool contrast agent code-7227. Radiology 202 (1997) 687-691
37. Hartmann, M., M. Forsting, O. Jansen, F. K. Albert, T. Balzer, K. Sartor: Verbessert die Hochdosisgabe eines paramagnetischen Kontrastmittels (Gadovist) die diagnostische Aussage der Magnetresonanztomographie bei Glioblastomen? Fortschr. Röntgenstr. 164 (1996) 119-125
38. Hiraishi, K., I. Narabayashi, O. Fujita, K. Yamamoto, A. Sagami, Y. Hisada, Y. Saika, I. Adachi, H. Hasegawa: Blueberry juice: preliminary evaluation as an oral contrast agent in gastrointestinal MR imaging. Radiology 194 (1995) 119-123
39. Hirohasi, S., R. Hirohashi, H. Uchida, S. Kitano, W. Ono, H. Ohishi, K. Nakanishi: MR cholangiopancreaticography and MR urography: improved enhancement with a negative oral contrast agent. Radiology 203 (1997) 281-285
40. Holman, E. R., A. C. van Rossum, T. Doesburg, E. E. van der Wall, A. de Roos, C. A. Visser: Assessment of acute myocardial infarction in man with magnetic resonance imaging and the use of a new paramagnetic contrast agent gadolinium-BOPTA. Magn. Reson. Imaging 14 (1996) 21-29
41. Jacobsen, T. F., M. Laniado, B. E. Van Beers, B. Dupas, F. P. Boudghene, E. Rummeny, T. H. Falke, P. A. Rinck, D. MacVicar, B. Lundby: Oral magnetic particles (ferristene) as a contrast medium in abdominal magnetic resonance imaging. Acad. Radiol. 3 (1996) 571-580
42. Johnson, W. K., C. Stoupis, G. M. Torres, E. B. Rosenberg, P. R. Ros: Superparamagnetic iron oxide (SPIO) as an oral contrast agent in gastrointestinal (GI) magnetic resonance imaging (MRI): comparison with state-of-the-art computed tomography (CT). Magn. Reson. Imaging 14 (1996) 43-49
43. Kaminsky, S., M. Laniado, M. Gogoll, W. Kornmesser, W. Clauss, M. Langer, C. Claussen, R. Felix: Gadopentetate dimeglumine as a bowel contrast agent: safety and efficacy. Radiology 178 (1991) 503-508
44. Kato, T., Y. Suto, T. Matsuo: Chondroitin sulfate iron colloid as an MR contrast agent for the hepatic reticuloendothelial system. J. Comput. Assist. Tomogr. 17 (1993) 603-608
45. Kettritz, U., J. F. Schlund, K. Wilbur, L. B. Eisenberg, R. C. Semelka: Comparison of gadolinium chelates with manganese-DPDP for liver lesion detection and characterization: preliminary results. Magn. Reson. Imaging 14 (1996) 1185-1190
46. Kettritz, U., D. M. Warshauer, E. D. Brown, J. F. Schlund, L. B. Eisenberg, R. C. Semelka: Enhancement of the normal pancreas: comparison of manganese-DPDP and gadolinium chelate. Eur. Radiol. 6 (1996) 14-18
47. Kopp, A. F., M. Laniado, K. P. Aicher, E. F. Grönewäller, C. D. Claussen: Mangan-DPDP als Kontrastmittel für die MR-Tomographie fokaler Leberläsionen. Fortschr. Röntgenstr. 157 (1992) 539-547
48. Kopp, A. F., M. Laniado, F. Dammann, W. Stern, E. F. Grönewäller, K. Shamsi, T. Balzer, C. D. Claussen: MR imaging of the liver with superparamagnetic iron oxides: Safety, efficacy, and pharmacodynamics after bolus injection of Resovist in 36 patients. Radiology 204 (1997) 749-756
49. Laniado, M., A. Chachuat: Verträglichkeitsprofil von Endorem. Radiologe 143 (1995) S24-S28
50. Laniado, M., W. Kornmesser, B. Hamm, W. Clauss, H. J. Weinmann, R. Felix: MR imaging of the gastrointestinal tract: value of Gd-DTPA. Amer. J. Roentgenol. 150 (1988) 817-821
51. Leung, D. A., G. C. McKinnon, C. P. Davis, T. Pfammatter, G. P. Krestin, J. F. Debatin: Breath-hold, contrast-enhanced, three-dimensional MR angiography. Radiology 200 (1996) 569-571
52. Liou, J., J. K. Lee, J. A. Borrello, J. J. Brown: Differentiation of hepatomas from non hepatomatous masses: use of Mn-DPDP-enhanced MR images. Magn. Reson. Imaging 12 (1994) 71-79
53. Marchal, G., P. Van Hecke, P. Demaerel, E. Decrop, C. Kennis, A. L. Baert, E. van der Schueren: Detection of liver metastases with superparamagnetic iron oxide in 15 patients: results of MR imaging at 1.5 T. Amer. J. Roentgenol. 152 (1989) 771-775
54. Mattrey, R. F., M. A. Trambert, J. J. Brown, S. W. Young, J. N. Bruneton, G. E. Wesbey, Z. N. Balsara: Perflubron as an oral contrast agent for MR imaging: results of a phase III clinical trial. Radiology 191 (1994) 841-848
55. Mayo Smith, W. W., S. Saini, G. Slater, J. A. Kaufman, P. Sharma, P. F. Hahn: MR contrast material for vascular enhancement: value of superparamagnetic iron oxide. Amer. J. Roentgenol. 166 (1996) 73-77
56. McLachlan, S. J., M. R. Morris, M. A. Lucas, R. A. Fisco, M. N. Eakins, D. R. Fowler, R. B. Scheetz, A. Y. Olukotun: Phase I clinical evaluation of a new iron oxide MR contrast agent. J. Magn. Reson. Imag. 4 (1994) 301-307
57. Mergo, P. J., T. Helmberger, A. I. Nicolas, P. R. Ros: Ring enhancement in ultrasmall superparamagnetic iron oxide MR imaging: a potential new sign for characterization of liver lesions. Amer. J. Roentgenol. 166 (1996) 379-384
58. Mitchell, D. G.: MR imaging contrast agents - what's in a name? J. Magn. Reson. Imag. 7 (1997) 1-4
59. Mitchell, D. G., E. K. Outwater, T. Matteucci, D. L. Rubin, J. L. Chezmar, S. Saini: Adrenal gland enhancement at MR imaging with Mn-DPDP. Radiology 194 (1995) 783-787
60. Murakami, T., R. L. Baron, M. P. Federle, M. S. Peterson, J. H. Oliver, P. L. Davis, S. R. Confer: Cirrhosis of the liver: MR imaging with mangafodipir trisodium (Mn-DPDP). Radiology 198 (1996) 567-572
61. Murakami, T., R. L. Baron, M. S. Peterson, J. H. Oliver, P. L. Davis, S. R. Confer, M. P. Federle: Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP). Radiology 200 (1996) 69-77
62. Murphy, K. J., J. A. Brunberg, R. H. Cohan: Adverse reactions to gadolinium contrast media: a review of 36 cases. Amer. J. Roentgenol. 167 (1996) 847-849
63. Nelson, K. L., L. M. Gifford, C. Lauber Huber, C. A. Gross, T. A. Lasser: Clinical safety of gadopentetate dimeglumine. Radiology 196 (1995) 439-443
64. Neuerburg, J., K. C. Klose, K. Bohndorf, S. Truong, R. W. Günther: MR-Tomographie kolorektaler Erkrankungen mit negativem rektalen Kontrastmittel. Fortschr. Röntgenstr. 156 (1992) 258-263
65. Oksendal, A. N., P. A. Hals Biodistribution and toxicity of MR imaging contrast media. J. Magn. Reson. Imag. 3 (1993) 157-165
66. 1-weighted MR imaging. Radiology 203 (1997) 449-456
67. Patten, R. M., S. K. Lo, J. J. Phillips, S. C. Bowman, G. M. Glazer, S. D. Wall, J. G. Bova, R. D. Harris, R. L. Wheat, C. D. Johnson, et al.: Positive bowel contrast agent for MR imaging of the abdomen: phase II and III clinical trials. Radiology 189 (1993) 277-283
68. Pavone, P., S. Giuliani, G. Cardone, R. Occhiato, P. Di Renzi, G. A. Petroni, C. Buoni, R. Passariello: Intraarterial portography with gadopentetate dimeglumine: improved liver-to-lesion contrast in MR imaging. Radiology 179 (1991) 693-697
69. Pels Rijcken, T. H., M. A. Davis, P. R. Ros: Intraluminal contrast agents for MR imaging of the abdomen and pelvis. J. Magn. Reson. Imag. 4 (1994) 291-300
70. Recht, M. P., J. Kramer, C. A. Petersilge, J. Yu, M. Pathria, D. Trudell, D. J. Sartoris, D. Resnick: Distribution of normal and abnormal fluid collections in the glenohumeral joint: implications for MR arthrography. J. Magn. Reson. Imag. 4 (1994) 173-177
71. Reimer, P., E. J. Rummeny, H. E. Daldrup, T. Balzer, B. Tombach, T. Berns, P. E. Peters: Clinical results with Resovist: a phase 2 clinical trial. Radiology 195 (1995) 489-496
72. Reimer, P., E. J. Rummeny, K. Shamsi, T. Balzer, H. E. Daldrup, B. Tombach, T. Hesse, T. Berns, P. E. Peters: Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 199 (1996) 177-183
73. Reimer, P., G. Schuierer, T. Balzer, P. E. Peters: Application of a superparamagnetic iron oxide (Resovist) for MR imaging of human cerebral blood volume. Magn. Reson. Med. 34 (1995) 694-697
74. Rinck, P. A., O. Smevik, G. Nilsen, O. Klepp, M. Onsrud, A. Oksendal, A. Borseth: Oral magnetic particles in MR imaging of the abdomen and pelvis. Radiology 178 (1991) 775-779
75. Rofsky, N. M., J. C. Weinreb, M. E. Bernardino, S. W. Young, J. K. T. Lee, M. E. Noz: Hepatocellular tumors: characterization with Mn-DPDP-enhanced MR imaging. Radiology 188 (1993) 53-59
76. Ros, P. R., P. C. Freeny, S. E. Harms, S. E. Seltzer, P. L. Davis, T. W. Chan, A. E. Stillman, L. R. Muroff, V. M. Runge, M. A. Nissenbaum, P. M. Jacobs: Hepatic MR imaging with ferumoxides: a multicenter clinical trial of the safety and efficacy in the detection of focal hepatic lesions. Radiology 196 (1995) 481-488
77. Ros, P. R., R. M. Steinman, G. M. Torres, S. S. Burton, J. L. Panaccione, D. C. Rappaport, S. P. McGorray: The value of barium as a gastrointestinal contrast agent in MR imaging: a comparison study in normal volunteers. Amer. J. Roentgenol. 157 (1991) 761-767
78. Rosati, G., G. Pirovano, A. Spinazzi: Interim results of phase II clinical testing of gadobenate dimeglumine. Invest. Radiol. 29 (1994)
79. Rummeny, E., C. Ehrenheim, H. B. Gehl, B. Hamm, M. Laniado, K. P. Lodemann, E. Schmiedel, A. Steudel, T. Vogl: Manganese-DPDP as a hepatobiliary contrast agent in the magnetic resonance imaging of liver tumors. Results of clinical phase II trials in Germany including 141 patients. Invest. Radiol. 26 (1991) S142-S145
80. Runge, V.M., W. G. Bradley, M. N. Brant Zawadzki, M. J. Carvlin, D. N. DeSimone, B. L. Dean, W. P. Dillon, B. P. Drayer, A. E. Flanders, S. E. Harms, et al: Clinical safety and efficacy of gadoteridol: a study in 411 patients with suspected intracranial and spinal disease. Radiology 181 (1991) 701-709
81. Saini, S., R. R. Edelman, P. Sharma, W. Li, W. Mayo Smith, G. J. Slater, P. J. Eisenberg, P. F. Hahn: Blood-pool MR contrast material for detection and characterization of focal hepatic lesions: initial clinical experience with ultrasmall superparamagnetic iron oxide (AMI-227). Amer. J. Roentgenol. 164 (1995) 1147-1152
82. Saini, S., M. T. Modic, B. Hamm, P. F. Hahn: Advances in contrast-enhanced MR imaging. Amer. J. Roentgenol. 156 (1991) 235-254
83. Saini, S., D. D. Stark, P. F. Hahn, J. Wittenberg, T. J. Brady, J. T. Ferrucci: Ferrite particles: a superparamagnetic MR contrast agent for the reticuloendothelial system. Radiology 162 (1987) 211-216
84. Schima, W., J. Petersein, P. F. Hahn, M. G. Harisinghani, E. Halpern, S. Saini: MR imaging of the liver: comparison between Gd-BOPTA and mangafodipir. J. Magn. Reson. Imag. 7 (1997) 130-135
85. Schmitz, S. A., J. H. Haberle, T. Balzer, K. Shamsi, J. Boese Landgraf, K. J. Wolf: Detection of focal liver lesions: CT of the hepatobiliary system with gadoxetic acid disodium, or Gd-EOB-DTPA. Radiology 202 (1997) 399-405
86. Schörner, W., R. Felix, M. Laniado, L. Lange, H. J. Weinmann, C. Claussen, W. Fiegler, U. Speck, E. Kazner: Prüfung des kernspintomographischen Kontrastmittels Gadolinium-DTPA am Menschen. Fortschr. Röntgenstr. 140 (1984) 493-500
87. Schuhmann-Giampieri, G.: Liver contrast media for magnetic resonance imaging. Interrelations between pharmacokinetics and imaging. Invest. Radiol. 28 (1993) 753-761
88. Schunk, K., W. Kersjes, S. Schadmand Fischer, P. Grebe, H. U. Kauczor, M. Thelen: Eine Mannitlösung als orales Kontrastmittel in der pelvinen MRT. Fortschr. Röntgenstr. 163 (1995) 60-66
89. Seneterre, E., P. Taourel, Y. Bouvier, J. Pradel, B. E. Van Beers, J. P. Daures, J. Pringot, D. Mathieu, J. M. Bruel: Detection of hepatic metastases: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography. Radiology 200 (1996) 785-792
90. Sorensen, A. G., A. L. Tievsky, L. Ostergaard, R. M. Weiskoff, B. R. Rosen: Contrast agents in functional MR imaging. J. Magn. Reson. Imag. 7 (1997) 47-55
91. Soyer, P.: Will ferumoxides-enhanced MR imaging replace CT during arterial portography in the detection of hepatic metastases? Prologue to a promising future. Radiology 201 (1997) 610-611
92. Stark, D. D., R. Weissleder, G. Elizondo, P. F. Hahn, S. Saini, L. E. Todd, J. Wittenberg, J. T. Ferrucci: Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 168 (1988) 297-301
93. Stillman, A. E., N. Wilke, D. Li, M. Haacke, S. McLachlan: Ultrasmall superparamagnetic iron oxide to enhance MRA of the renal and coronary arteries: studies in human patients. J. Comput. Assist. Tomogr. 20 (1996) 51-55
94. Suto, Y., F. Kodama, M. Kamba, Y. Ohta: Correlation between chondroitin sulfate iron colloid-enhanced MR imaging and the histological grade of hepatocellular carcinoma. Acta Radiol. 36 (1995) 102-105
95. Sze, G., M. Brant Zawadzki, V. M. Haughton, K. R. Maravilla, M. T. McNamara, A. J. Kumar, A. M. Aisen, J. N. Dreisbach, W. G. Bradley jr., J. C. Weinreb, B. P. Drayer, J. S. Tsuruda, C. E. Hesselink, C. E. Johnson, R. D. Zimmermann, G. R. Weingast: Multicenter study of gadodiamide injection as a contrast agent in MR imaging of the brain and spine. Radiology 181 (1991) 693-699
96. Torres, C. G., B. Lundby, A. Tufte Sterud, S. McGill, P. B. Gordon, H. Strand Bjerknes: MnDPDP for MR imaging of the liver. Results from the European phase III studies. Acta Radiol. 38 (1997) 631-637
97. Treinen, K. A., T. J. Gray, W. F. Blazak: Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats. Teratology 52 (1995) 109-115
98. 1-Effekt für die MR-Diagnostik fokaler Leberläsionen? Fortschr. Röntgenstr. 165 (1996) 364-370
99. 1-weighted turbo-field-echo images: implications for tumor characterization. J. Magn. Reson. Imag. 7 (1997) 485-489
100. Vogl, T. J., B. Hamm, B. Schnell, C. McMahon, G. Branding, J. Lissner, K. S. Wolf: Mn-DPDP enhancement patterns of hepatocellular lesions on MR images. J. Magn. Reson. Imag. 3 (1993) 51-58
101. Vogl, T. J., R. Hammerstingl, W. Pegios, B. Hamm, A. EiblEibesfeldt, B. Woessmer, J. Lissner, R. Felix: Wertigkeit des leberspezifischen superparamagnetischen Kontrastmittels AMI-25 für die Detektion und Differentialdiagnose lebereigener Tumoren versus Metastasen. Fortschr. Röntgenstr. 160 (1994) 319-328
102. Vogl, T. J., R. Hammerstingl, W. Schwarz, M. G. Mack, P. K. Muller, W. Pegios, H. Keck, A. Eibl Eibesfeldt, J. Hoelzl, B. Woessmer, C. Bergman, R. Felix: Superparamagnetic iron oxide-enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions. Radiology 198 (1996) 881-887
103. Vogl, T. J., S. Kummel, R. Hammerstingl, M. Schellenbeck, G. Schumacher, T. Balzer, W. Schwarz, P. K. Muller, W. O. Bechstein, M. G. Mack, O. Sollner, R. Felix: Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology 200 (1996) 59-67
104. Vogl, T. J., W. Pegios, C. McMahon, J. Balzer, J. Waitzinger, G. Pirovano, J. Lissner: Gadobenate dimeglumine - a new contrast agent for MR imaging: preliminary evaluation in healthy volunteers. Amer. J. Roentgenol. 158 (1992) 887-892
105. Weinmann, H. J.: Blutpool-Kontrastmittel. MR'97 22.-26.1. 1997, Garmisch-Partenkirchen (1997) (Abstract)
106. Weinmann, H. J., R. C. Brasch, G. E. Wesbey: Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. Amer. J. Roentgenol. 142 (1984) 619-624
107. Weissleder, R.: Liver MR imaging with iron oxides: toward consensus and clinical practice. Radiology 193 (1994) 593-595
108. Weissleder, R., G. Elizondo, D. D. Stark, P. F. Hahn, J. Marfil, J. F. Gonzalez, S. Saini, L. E. Todd, J. T. Ferrucci: The diagnosis of splenic lymphoma by MR imaging: value of superparamagnetic iron oxide. Amer. J. Roentgenol. 152 (1989) 175-180
109. Weissleder, R., P. F. Hahn, D. D. Stark, G. Elizondo, S. Saini, L. E. Todd, J. Wittenberg, J. T. Ferrucci: Superparamagnetic iron oxide: enhanced detection of focal splenic tumors with MR imaging. Radiology 169 (1988) 399-403
110. Weissleder, R., D. D. Stark, B. L. Engelstad, B. R. Bacon, C. C. Compton, D. L. White, P. Jacobs, J. Lewis: Superparamagnetic iron oxide: pharmacokinetics and toxicity. Amer. J. Roentgenol. 152 (1989) 167-173
111. Wesbey, G. E., R. C. Brasch, B. L. Engelstad, A. A. Moss, L. E. Crooks, A. C. Brito: Nuclear magnetic resonance contrast enhancement study of the gastrointestinal tract of rats and a human volunteer using nontoxic oral iron solutions. Radiology 149 (1983) 175-180
112. Winter, T. C., P. C. Freeny, H. V. Nghiem, L. A. Mack, R. M. Patten, C. R. Thomas jr., S. Elliott: MR imaging with i.v. superparamagnetic iron oxide: efficacy in the detection of focal hepatic lesions. Amer. J. Roentgenol. 161 (1993) 1191-1198
113. Yamamoto, H., Y. Yamashita, S. Yoshimatsu, Y. Baba, Y. Hatanaka, R. Murakami, T. Nishiharu, M. Takahashi, Y. Higashida, N. Moribe: Hepatocellular carcinoma in cirrhotic livers: detection with unenhanced and iron oxide-enhanced MR imaging. Radiology 195 (1995) 106-112
114. Yamashita, Y., H. Yamamoto, A. Hirai, S. Yoshimatsu, Y. Baba, M. Takahashi: MR imaging enhancement with superparamagnetic iron oxide in chronic liver disease: influence of liver dysfunction and parenchymal pathology. Abdom. Imaging 21 (1996) 318-323
115. Yoshikawa, K., Y. Sasaki, N. Ogawa, S. Sakuma: Clinical application of AMI-25 (superparamagnetic iron oxide) for MR imaging of hepatic tumors: a multicenter clinical phase III study. Nippon Acta Radiol. 54 (1994) 137-153
116. Young, S. W., F. Qing, D. Rubin, K. J. Balkus jr., J. S. Engel, J. Lang, W. C. Dow, J. D. Mutch, R. A. Miller: Gadolinium zeolite as an oral contrast agent for magnetic resonance imaging. J. Magn. Reson. Imag. 5 (1995) 499-508