Oral contraceptives and bone metabolism

European Journal of Contraception and Reproductive Health Care

Volumn 2, Issue 4, 1997, Pages 225-228

  Volpe, A ^a,b   Malmusi, S ^a   Zanni, A L ^a   Landi, S ^a   Cagnacci, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Clinica Ginecologica e Ostetrica   (Italy)

Author keywords

Amenorrhea; Anovulation; Bone metabolism; Normally cycling women; Oral contraception; Progestins

Indexed keywords

DRUG DERIVATIVE; ESTROGEN; GONADORELIN; ORAL CONTRACEPTIVE AGENT;

ADOLESCENT; ADULT; BONE DENSITY; BONE REMODELING; DRUG EFFECT; FEMALE; HUMAN; MIDDLE AGED; PHYSIOLOGY; POSTMENOPAUSE OSTEOPOROSIS; REVIEW;

ADOLESCENT; ADULT; BONE DENSITY; BONE REMODELING; CONTRACEPTIVES, ORAL; ESTROGENS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HUMANS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL;

EID: 0031306127     PISSN: 13625187     EISSN: None     Source Type: Journal    
DOI: 10.3109/13625189709165298     Document Type: Article

References (34)

1. Manolagas SC, Jilka RL. Bone marrow, cytokines and bone remodelling. N Engl J Med 1995; 332: 305-11
2. Cohn SH, Vaswani A, Zanzi I, et al. Effect of aging on bone mass in adult women. Am J Physiol 1976; 230: 143-50
3. Turner RT, Riggs BL, Spelsberg TC. Skeletal effects of estrogen. Endocr Rev 1994; 15: 275-300
4. Prince RL. Counterpoint: estrogen effects on calcitropic hormones and calcium homeostasis. Endocr Rev 1994; 15: 301-9
5. Prelevic GM, Beljic T, Balint-Peric L, et al. Effect of two different progestins (cyproterone acetate and norgestrel), administered in a cyclical estradiol valerate regimen, on markers of bone turnover. Gynecol Endocrinol 1994; 8: 209-14
6. Weryha G, Leclere J. Paracrine regulation of bone remodeling. Horm Res 1995; 43: 69-75
7. Tremollieres FA, Strong DD, Bayling DJ, et al. Progesterone and promegestone stimulate human bone cell proliferation and insulin-like growth factor-2 production. Acta Endocrinol 1992; 126: 329-37
8. Jordan VC, Jeng MH, Catherino WH, et al. The estrogenic activity of synthetic progestins used in oral contraceptives. Cancer 1993; 71: 1501-5
9. Verhaar HJJ, Damen CA, Duursma SA, et al. A comparison of the action of progestins and estrogen on the growth and differentiation of normal adult human osteoblast-like cells in vitro. Bone 1994; 15: 307-11
10. Caird LE, Reid-Thomas V, Hannan WJ, et al. Oral progestogen-only contraception may protect against loss of bone mass in breast-feeding women. Clin Endocrinol 1994; 41: 739-45
11. DeCherney A. Physiologic and pharmacologic effects of estrogen and progestins on bone. J Reprod Med 1993; 38: 1007-14
12. Cromer BA, McArdle J, Mahan JD, et al. A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives. J Pediatr 1996; 129: 671-6
13. Naessen T, Olsson SE, Gudmundson J. Differential effects on bone density of progestogen-only methods for contraception in premenopausal women. Contraception 1995; 52: 35-9
14. Hreshchshyn MM, Hopkins A, Zylstra S, et al. Associations of parity, breast-feeding and birth control pills with lumbar spine and femoral bone densities. Am J Obstet Gynecol 1988; 159: 318-22
15. Lloyd T, Buchanan JR, Ursino GR, et al. Long-term oral contraceptive use does not affect trabecular bone density. Am J Obstet Gynecol 1989; 160: 402-4
16. Lindsay R, Tohme J, Kanders B. The effect of oral contraceptive use on vertebral bone mass in pre and postmenopausal women. Contraception 1986; 34: 333-40
17. Kritz-Silverstein D, Barrett-Connor E. Bone mineral content in postmenopausal women as determined by prior oral contraceptive use. Am J Public Health 1993; 83: 100-2
18. Cooper C, Hannaford P, Croft P, et al. Oral contraceptive pill use and fractures in women: a prospective study. Bone 1993; 14: 41-5
19. Hartard M, Bottermann P, Bartenstein P, et al. Effects on bone mineral density of low-dosed oral contraceptives compared to and combined with physical activity. Contraception 1997; 55: 87-90
20. Volpe A, Silferi M, Genazzani AD, et al. Contraception in older woman. Contraception 1993; 47: 229-39
21. Brown DM, Jowsey J, Bradford DS. Osteoporosis in ovarian dysgenesis J Pediatr 1984; 84: 816-20
22. Ayers JWT, Gidwani GP, Schmidt BM. Osteopenia in hypoestrogenic young women with anorexia nervosa. Fertil Steril 1984; 41: 224-8
23. Rigotti NA, Nussbaum SR, Herzog DB, et al. Osteoporosis in women with anorexia nervosa. N Engl J Med 1984; 311: 1601-6
24. Emans SJ, Grace E, Hoffer FA, et al. Estrogen deficiency in adolescents and young adults: impact on bone mineral content and effects of estrogen replacement therapy. Obstet Gynecol 1990; 76: 585-92
25. Jones KP, RavnikarVA,Tulchinsky D, et al. Comparison of bone density in amenorrheic women due to athletics, weight loss and premature menopause. Obstet Gynecol 1985; 66: 5-8
26. Cann CE, Martin MC, Genant HK, et al. Decreased spinal mineral content in amenorrheic women. J Am Med Assoc 1984; 251: 626-9
27. Klibanski A, Neer RM, Beitins IZ, et al. Decreased bone density in hyperprolactinemic women. N Engl J Med 1980; 303: 1511-14
28. Klibanski A, Biller BMK, Schoenfeld DA, et al. The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. J Clin Endocrinol Metal 1995; 80: 898-904
29. Paoletti AM, Serra GG, Cagnacci A, et al. Spontaneous reversibility of bone loss induced by gonadotropin-releasing hormone analog treatment. Fertil Steril 1996; 65: 707-10
30. Leather AT, Studd JWW, Watson NR, et al. The prevention of bone loss in young women treated with GnRH analogues with 'add-back' estrogen therapy. Obstet Gynecol 1993; 81: 104-7
31. Castelo-Branco C, Martinez de Osaba M, Pons F, et al. Gonadotropin-releasing hormone analog plus an oral contraceptive containing desogestrel in women with severe hirsutism: effects on hair, bone and hormone profile after 1 year use. Metabolism 1997; 46: 437-40
32. Gambacciani M, Spinetti A, Taponeco F, et al. Premenopausal bone loss in oligomenorrhoic women: a longitudinal study. Maturitas 1994; 18: 131-7
33. Gambacciani M, Spinetti A, Cappagli B, et al. Hormone replacement therapy in perimenopausal women with a low dose oral contraceptive preparation: effects on bone mineral density and metabolism. Maturitas 1994; 19: 125-31
34. Mais V, Fruzzetti F, Ajossa S, et al. Bone metabolism in young women taking a monophasic pill containing 20 mcg ethinylestradiol: a prospective study. Contraception 1993; 48: 445-52