C1q Augments Platelet Activation in Response to Aggregated Ig

Journal of Immunology

Volumn 159, Issue 11, 1997, Pages 5594-5598

  Peerschke, Ellinor I B ^a,b,c   Ghebrehiwet, Berhane ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1Q; F(AB')2 RECEPTOR; FC RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN KINASE;

ARTICLE; HEAT; HUMAN; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; THROMBOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; COMPLEMENT C1Q; HEAT; HUMANS; IMMUNOGLOBULIN G; PHOSPHORYLATION; PLATELET ACTIVATION; PROTEIN KINASES; RECEPTORS, IGG; RECEPTORS, IMMUNOLOGIC;

EID: 0031298116     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Theofilopoulos, A. N., and F. J. Dixon. 1980. Immune complexes in human diseases. Am. J. Pathol. 100:530.
2. Karpatkin, S., N. Strick, M. B. Karpatkin, and G. W. Siskind. 1973. Heavy chain subclass of human anti-platelet antibodies. Clin. Immunol. Immunopathol. 2:1.
3. Henson, P. M. 1982. Antibody and immune-complex mediated allergic and inflammatory reactions. In Clinical Aspects of Immunology. P. J. Lachmann and D. D. Peters, eds. Blackwell Scientific Publications, Oxford, pp. 687-709.
4. Kelton, J. G., D. Sheridan, A. Santos, J. Smith, K. Steeves, C. Smith, C. Browen, and W. G. Murphy. 1988. Heparin-induced thrombocytopenia: laboratory studies. Blood 72:925.
5. Chong, B. M., H. I. Fawaz, C. N. Chesterman, and M. C. Berndt. 1989. Heparin-induced thrombocytopenia: mechanism of interactions of the heparin-dependent antibody with platelets. Br. J. Haematol. 73:235.
6. Amiral, J., F. Bridey, M. Dreyfus, A. M. Vissac, E. Fressinaud, M. Wolf, and D. Meyer. 1992. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb. Haemost. 68:95.
7. Israels, E. D., G. Nisli, F. Paraskevas, and L. G. Israels. 1973. Platelet Fc receptor as a mechanism for antigen-antibody complex-induced platelet injury. Thromb. Diath. Haemorrh. 29:434.
8. Mueller-Eckhardt, C., and E. F. Luscher. 1968. Immune reactions of human blood platelets. I. A comparative study on the effects on platelets of heterologous antiplatelet antiserum, antigen-antibody complexes, aggregated γ globulins, and thrombin. Thromb. Diath. Haemorrh. 20:155.
9. Henson, P. M., and H. L. Spiegelberg. 1973. Release of serotonin from human platelets induced by aggregated immunoglobulins of different classes and subclasses. J. Clin. Invest. 52:1282.
10. Theofilopoulos, A. N., and F. J. Dixon. 1979. The biology and detection of immune complexes. Adv. Immunol. 28:89.
11. Anderson, C. L., G. W. Chacko, J. M. Osborne, and J. T. Brandt. 1995. The Fc receptor for immunoglobulin G (FcγRII) on human platelets. Semin. Thromb. Hemost. 21:1.
12. Peerschke, E. I. B., and B. Ghebrehiwet. 1990. Platelet C1q receptor interactions with collagen and C1q-coated surfaces. J. Immunol. 145:2984.
13. Sims, P. J., E. M. Faioni, T. Wiedmer, and S. J. Shattil. 1988. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombin activity. J. Biol. Chem. 263:18205.
14. Peerschke, E. I. B., K. B. M. Reid, and B. Ghebrehiwet. 1993. Platelet activation by C1q results in the induction of αIIb/β3 integrins (GPIIb-IIIa) and the expression of P-selectin and procoagulant activity. J. Exp. Med. 178:579.
15. Peerschke, E. I. B., and B. Ghebrehiwet. 1992. Platelet interactions with C1q in whole blood and in the presence of immune complexes or aggregated IgG. Clin. Immunol. Immunopathol. 63:45.
16. Larsson, A., N. Egberg, and T. L. Lindahl. 1994. Platelet activation and binding of complement components to platelets induced by immune complexes. Platelets 5:149.
17. van den Dobbelstee, M. E. A., F. J. van der Woude, W. E. M. Schroeijers, N. Klar-Mohamad, L. A. van Es, and M. R. Daha. 1993. C1q, a subunit of the first component of complement, enhances the binding of aggregated IgG to rat renal mesangial cells. J. Immunol. 151:4315.
18. Anderson, G. P., and C. L. Anderson. 1990. Signal transduction by the platelet Fc receptor. Blood 76:1165.
19. Horsewood, P., C. P. M. Hayward, T. E. Warkentin, and J. G. Kelton. 1991. Investigation of the mechanisms of monoclonal antibody-induced platelet activation. Blood 78:1019.
20. Bachelot, C., R. Saffroy, S. Gandrille, M. Aiach, and F. Rendu. 1995. Role of FcyRIIA gene polymorphism in human platelet activation by monoclonal antibodies. Thromb. Haemost. 74:1557.
21. Yonemasu, K., and R. M. Stroud. 1971. C1q: rapid purification method for preparation of monospecific antisera and for biochemical studies. J. Immunol. 106: 304.
22. Peerschke, E. I. B., M. B. Zucker, R. A. Grant, J. J. Egan, and M. M. Johnson. 1980. Correlation between fibrinogen binding to human platelets and platelet aggregability. Blood 55:841.
23. Ghebrehiwet, B., S. Bossone, A. Erdei, and K. B. M. Reid. 1988. Reversible biotinylation of C1q with a cleavable biotinyl derivative: application in C1q receptor (C1qR) purification. J. Immunol. Methods 110:251.
24. Clark, W. F., G. J. M. Tevaarwerk, and B. D. Reid. 1982. Human platelet-immune complex interaction in plasma. J. Lab. Clin. Med. 100:917.
25. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
26. Lipfert, L., B. Haimovich, M. D. Schaller, B. S. Cobb, J. T. Parsons, and J. S. Brugge. 1992. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J. Cell Biol. 119:905.
27. Shattil, S. J., M. H. Ginsberg, and J. S. Brugge. 1994. Adhesive signaling in platelets. Curr. Opin. Cell Biol. 6:695.
28. Parbtani, A., W. F. Clark, A. Caverney, and B. Reid. 1987. Binding of aggregated immunoglobulins to the human platelet Fc receptors: a mechanism of platelet to platelet binding. Thromb. Haemost. 58:966.
29. Coller, B. S., E. I. Peerschke, L. E. Scudder, and C. A. Sullivan. 1983. A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenia-like state in normal platelets and binds glycoprotein IIB and/or IIIa. J. Clin. Invest. 72:325.
30. Ghebrehiwet, B., and E. I. B. Peerschke. 1993. The C1q-R participates in immunoregulation and signal transduction. Behr. Inst. Min. 93:236.
31. Ziccardi, R. J., and N. Cooper. 1977. The subunit composition and compositional properties of human C1. J. Immunol. 118:2047.
32. Tenner, A. J., and N. R. Cooper. 1980. Analysis of receptor mediated C1q binding to human peripheral blood mononuclear cells. J. Immunol. 125:1658.
33. Sim, R. B., G. J. Arlaud, and M. G. Colomb. 1979. C1 inhibitor dependent dissociation of human complement component C1 bound to immune complexes. Biochem. J. 179:449.
34. Peerschke, E. I. B., and B. Ghebrehiwet. 1987. Human blood platelets possess specific binding sites for C1q. J. Immunol. 138:1537.
35. Lindgren, S., A. B. Laurell, and S. Eriksson. 1984. Complement components and activity in primary biliary cirrhosis. Hepatology 4:9.
36. Loos, M., H. Martin, and F. Petry. 1989. The biosynthesis of C1q, the collagen-like and Fc-recognizing molecule of the complement system. Behr. Inst. Mitt. 84:32.
37. Vlaicu, R., H. G. Rus, F. Niculescu, and A. Cristea. 1985. Immunoglobulin and complement components in human aortic atherosclerotic intima. Atherosclerosis 55:35.
38. Niewiarowski, S., and D. Paul. 1981. Platelet granule proteins with mitogenic and antiheparin activity. In Platelets in Biology and Pathology, Vol. 2. J. L. Gordon, ed. Elsevier/North-Holland Biomedical Press, New York, pp. 91-106.