Reproductive Safety of Melatonin: A "Wonder Drug" to Wonder About

Journal of Biological Rhythms

Volumn 12, Issue 6, 1997, Pages 682-689

  Weaver, David R ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Contraception; Melatonin; Prenatal exposure; Puberty; Reproduction; Toxicity

Indexed keywords

ANIMALIA;

MELATONIN;

ANIMAL; DRUG EFFECT; FEMALE; HUMAN; PREGNANCY; REPRODUCTION; REVIEW;

ANIMALS; FEMALE; HUMANS; MELATONIN; PREGNANCY; REPRODUCTION;

EID: 0031297442     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: 10.1177/074873049701200625     Document Type: Article

References (28)

1. Bartness TJ, Powers JB, Hastings MH, Bittman EL, and Goldman BD (1993). The timed infusion paradigm: What has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses. J Pineal Res 15:161-190.
2. Berria M, DeSantis M, and Mead RA (1989) Lesions to the anterior hypothalamus prevent the melatonin-induced lengthening of delayed implantation. Endocrinology 125:2897-2904.
3. Brzezinski A (1997) Melatonin in humans. N Engl J Med 336:186-195.
4. Carr L, Ruther E, Berg PA, and Lehnert H (1994) Eosinophiliamyalgia syndrome in Germany: An epidemiologic review. Mayo Clin Proc 69:620-625.
5. Cohen M, Small RA, and Brzezinski A (1995) Hypotheses: Melatonin/steroid combination contraceptives will prevent breast cancer. Breast Cancer Res Treat 33:257-264.
6. Davis FC (1997) Melatonin: Role in development. J Biol Rhythms 12:498-508.
7. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, and Deng MH (1994) Effects of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 91:1824-1828.
8. Gortmaker SL, Kagan J, Caspi A, and Silva PA (1997) Daylength during pregnancy and shyness in children: Results from Northern and Southern hemispheres. Dev Psychobiol 31:107-114.
9. Horton TH, Ray SL, and Stetson MH (1989) Maternal transfer of photoperiodic information in Siberian hamsters: III. Melatonin injections program postnatal reproductive development expressed in constant light. Biol Reprod 41:34-39.
10. Karsch FJ, Bittman EL, Foster DL, Goodman RL, Legan SJ, and Robinson JE (1984) Neuroendocrine basis of seasonal reproduction. Recent Prog Horm Res 40:185-232.
11. Lawson NO, Wee BE, Blask DE, Castles CG, Spriggs LL, and Hill SM (1992) Melatonin decreases estrogen receptor expression in the medial preoptic area of inbred (LSH/SsLak) golden hamsters. Biol Reprod 47:1082-1090.
12. McElhinny AS, Davis FC, and Warner CM (1996) The effects of melatonin on cleavage rate on C57BL/6 and CBA/Ca preimplantation embryos cultured in vitro. J Pineal Res 21:44-48.
13. McGivern RF and Handa RJ (1996) Prenatal exposure to drugs of abuse: Methodological considerations and effects on sexual differentiation. NIDA Res Monogr 164:78-124.
14. Molis TM, Spriggs LL, and Hill SM (1994) Modulation of estrogen receptor mRNA expression by melatonin in MCF-7 human breast cancer cells. Mol Endocrinol 8:1681-1690.
15. Neville S, Arendt J, and Ioannides C (1989) A study of the mutagenicity of melatonin and 6-hydroxymelatonin. J Pineal Res 6:73-76.
16. Pang SF, Dubocovich ML, and Brown GM (1993) Melatonin receptors in peripheral tissues: A new area of melatonin research. Biol Signals 2:177-180.
17. Pierpaoli W and Regelson W (1995) The Melatonin Miracle, Simon & Schuster, New York.
18. Reiter RJ and Robinson J (1995) Melatonin: Your Body's Natural Wonder Drug, Bantam, New York.
19. Reppert SM and Weaver DR (1995) Melatonin madness. Cell 83:1059-1062.
20. Stankov B, Gervasoni M, Scaglione F, Perego R, Cova D, Marabini L, and Fraschini F (1993) Primary pharmacotoxicological evaluation of 2-iodomelatonin, a potent melatonin agonist. Life Sci 53:1357-1365.
21. Sugden D (1983) Psychopharmacological effects of melatonin in mouse and rat. J Pharmacol Exp Ther 227:587-591.
22. Voordouw BC, Euser R, Verdonk RE, Alberda BT, de Jong FH, Drogendijk AC, Fauser BC, and Cohen M (1992) Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab 74:108-117.
23. Waldhauser F, Boepple PA, Schemper M, Mansfield MJ, and Crowley WF Jr (1991) Serum melatonin in central precocious puberty is lower than in age-matched prepubertal children. J Clin Endocrinol Metab 73:793-796.
24. Waldhauser F, Lieberman HR, Lynch HJ, Waldhauser M Herkner K, Frisch H, Vierhapper H, Waldhausl W, Schemper M, Wurtman RJ, and Crowley WF (1987) A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone, or cortisol. Neuroendocrinology 46:125-130.
25. Waldhauser F, Weiszenbacher G, Frisch H, Zeitlhuber U, Waldhauser M, and Wurtman RJ (1984) Fall in nocturnal serum melatonin during prepuberty and pubescence. Lancet 335:362-365.
26. Weaver DR and Reppert SM (1989) Maternal communication of daylength information to the fetus. In Development of Circadian Rhythmicity and Photoperiodism in Mammals, SM Reppert, ed, pp 209-219, Perinatology Press, Ithaca, NY.
27. Weaver DR, Stehle JH, Stopa EG, and Reppert SM (1993) Melatonin receptors in human hypothalamus and pituitary: Implications for circadian and reproductive responses to melatonin. J Clin Endocrinol Metab 76:295-301.
28. Wilson ME, Lackey S, Chikazawa K, and Gordon TP (1993) The amplitude of nocturnal melatonin concentrations is not decreased by oestradiol and does not alter reproductive function in adolescent or adult female rhesus monkeys. J Endocrinol 137:299-309.