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Volumn 2, Issue 3-4, 1997, Pages 191-198

Vasculoprotective effects of LEX-032, a novel recombinant serpin, during splanchnic ischemia and reperfusion

Author keywords

Endothelial dysfunction; Mean arterial blood pressure; Myeloperoxidase activity; Superior mesenteric artery; Survival time

Indexed keywords

ACETYLCHOLINE; LEX 032; MYELOPEROXIDASE; RECOMBINANT PROTEIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0031295623     PISSN: 10887180     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (1)

References (40)
  • 1
    • 0026449657 scopus 로고
    • Neutrophil activation and function in health and disease
    • ed. Coffey RG. New York: Dekker
    • Johnson KJ, Varani J, Smolen JE: Neutrophil activation and function in health and disease. In: Granulocyte Response to Cytokines, ed. Coffey RG. New York: Dekker, 1992; 1-46.
    • (1992) Granulocyte Response to Cytokines , pp. 1-46
    • Johnson, K.J.1    Varani, J.2    Smolen, J.E.3
  • 2
    • 0025370491 scopus 로고
    • Mediation of cardioprotection by transforming growth factor-β
    • Lefer AM, Tsao P, Aokí N, and Palladino MA, Jr.: Mediation of cardioprotection by transforming growth factor-β. Science 1990; 249:61-64.
    • (1990) Science , vol.249 , pp. 61-64
    • Lefer, A.M.1    Tsao, P.2    Aokí, N.3    Palladino Ma, J.4
  • 3
    • 0027164220 scopus 로고
    • In vivo neutralization of p-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury
    • Weyrich AS, Ma X-L, Lefer DJ, Albertine KH, Lefer AM: In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest 1993; 91:2620-2629.
    • (1993) J Clin Invest , vol.91 , pp. 2620-2629
    • Weyrich, A.S.1    Ma, X.-L.2    Lefer, D.J.3    Albertine, K.H.4    Lefer, A.M.5
  • 4
    • 0030975020 scopus 로고    scopus 로고
    • The cytokine-adhesion molecule cascade in ischemia/ reperfusion injury of the rat kidney. Inhibition by a soluble p-selectin ligand
    • Takada M, Nadeau KC, Shaw GD, Marquette KA, Tilney NL: The cytokine-adhesion molecule cascade in ischemia/ reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand. J Clin Invest 1997; 99:2682-2690.
    • (1997) J Clin Invest , vol.99 , pp. 2682-2690
    • Takada, M.1    Nadeau, K.C.2    Shaw, G.D.3    Marquette, K.A.4    Tilney, N.L.5
  • 5
    • 0028021565 scopus 로고
    • Role of P-selectin in microvascular leukocyte-endothelial interaction in splanchnic ischemia-reperfusion
    • Davenpeck KL, Gauthier TW, Albertine KH, Lefer AM: Role of P-selectin in microvascular leukocyte-endothelial interaction in splanchnic ischemia-reperfusion. Am J Physiol 1994; 267:H622-H630.
    • (1994) Am J Physiol , vol.267
    • Davenpeck, K.L.1    Gauthier, T.W.2    Albertine, K.H.3    Lefer, A.M.4
  • 6
    • 0024367923 scopus 로고
    • Leukocyte adherence to vascular endothelium during ischemia-reperfusion
    • Granger DN, Benoit JN, Suzuki M, Grisham MB: Leukocyte adherence to vascular endothelium during ischemia-reperfusion. Am J Physiol 1989; 257:G683-G688.
    • (1989) Am J Physiol , vol.257
    • Granger, D.N.1    Benoit, J.N.2    Suzuki, M.3    Grisham, M.B.4
  • 7
    • 0026667253 scopus 로고
    • Granulocyte accumulation in postischemic intestine: Role of leukocyte adhesion glycoprotein CD11/CD18
    • Kurtel H, Tso P, Granger DN: granulocyte accumulation in postischemic intestine: role of leukocyte adhesion glycoprotein CD11/CD18. Am J Physiol 1992; 262:G878-G882.
    • (1992) Am J Physiol , vol.262
    • Kurtel, H.1    Tso, P.2    Granger, D.N.3
  • 8
    • 0026006064 scopus 로고
    • Morphological assessment of leukocyte-endothelial cell interactions in mesenteric venules subjected to ischemia and reperfusion
    • Oliver MG, Specian RD, Perry MA, Granger DN: Morphological assessment of leukocyte-endothelial cell interactions in mesenteric venules subjected to ischemia and reperfusion. Inflammation 1991; 15:331-346.
    • (1991) Inflammation , vol.15 , pp. 331-346
    • Oliver, M.G.1    Specian, R.D.2    Perry, Ma.3    Granger, D.N.4
  • 9
    • 0030788232 scopus 로고    scopus 로고
    • Pharmacology and pharmacokinetics of LEX-032, a bioengineered serpin: The first of a potential new class of drugs
    • Sands H, Hook JB: Pharmacology and pharmacokinetics of LEX-032, a bioengineered serpin: The first of a potential new class of drugs. Drug Metab Rev 1997; 29:309-328.
    • (1997) Drug Metab Rev , vol.29 , pp. 309-328
    • Sands, H.1    Hook, J.B.2
  • 10
    • 0028003456 scopus 로고
    • Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil released mediators
    • Buerke M, Weyrich AS, Lefer AM: Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil released mediators. Am J Physiol 1994; 266:H128-H136.
    • (1994) Am J Physiol , vol.266
    • Buerke, M.1    Weyrich, A.S.2    Lefer, A.M.3
  • 11
    • 0024602827 scopus 로고
    • Tissue destruction by neutrophils
    • Weiss SJ: Tissue destruction by neutrophils. N Engl J Med 1989; 320:365-376.
    • (1989) N Engl J Med , vol.320 , pp. 365-376
    • Weiss, S.J.1
  • 12
    • 0028180971 scopus 로고
    • Conversion of a1-anti-chymotrypsin into a human neutrophil elastase inhibitor: Demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities
    • Rubin H, Plotnick M, Wang Z, Liu X, Zhong Q, Schlechter NM, Cooperman BS: Conversion of a1-anti-chymotrypsin into a human neutrophil elastase inhibitor: Demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities. Biochemistry 1994; 33:7627-7633.
    • (1994) Biochemistry , vol.33 , pp. 7627-7633
    • Rubin, H.1    Plotnick, M.2    Wang, Z.3    Liu, X.4    Zhong, Q.5    Schlechter, N.M.6    Cooperman, B.S.7
  • 13
    • 0029968471 scopus 로고
    • Novel recombinant serpin, LEX-032, attenuates myocardial reperfusion injury in cats
    • Delyani JA, Murohara T, Lefer AM: Novel recombinant serpin, LEX-032, attenuates myocardial reperfusion injury in cats. Am J Physiol 1995; 270:H881-H887.
    • (1995) Am J Physiol , vol.270
    • Delyani, J.A.1    Murohara, T.2    Lefer, A.M.3
  • 14
    • 0029048266 scopus 로고
    • Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury
    • Murohara T, Guo J-P, Lefer AM: Cardioprotection by a novel recombinant serine protease inhibitor in myocardial ischemia and reperfusion injury. J Pharm Exp Ther 1995; 274:1246-1253.
    • (1995) J Pharm Exp Ther , vol.274 , pp. 1246-1253
    • Murohara, T.1    Guo, J.-P.2    Lefer, A.M.3
  • 15
    • 0029383598 scopus 로고
    • Beneficial effects of LEX-032, a novel recombinant serine protease inhibitor, in murine traumatic shock
    • Scalia R, Gauthier TW, Lefer AM: Beneficial effects of LEX-032, a novel recombinant serine protease inhibitor, in murine traumatic shock. Shock 1995; 4:251-256.
    • (1995) Shock , vol.4 , pp. 251-256
    • Scalia, R.1    Gauthier, T.W.2    Lefer, A.M.3
  • 16
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: Estimation of the neutrophil content with an enzyme marker
    • Bradley PP, Priebat DA, Christensen RD, Rohstein GR: Measurement of cutaneous inflammation: Estimation of the neutrophil content with an enzyme marker. J Invest Dermatol 1982; 78:206-209.
    • (1982) J Invest Dermatol , vol.78 , pp. 206-209
    • Bradley, P.P.1    Priebat, D.A.2    Christensen, R.D.3    Rohstein, G.R.4
  • 17
    • 0021998590 scopus 로고
    • Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
    • Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J. Pharmacol. Methods 1985; 14:157-167.
    • (1985) J. Pharmacol. Methods , vol.14 , pp. 157-167
    • Mullane, K.M.1    Kraemer, R.2    Smith, B.3
  • 18
    • 0025104450 scopus 로고
    • A method for isolation and fluorescent labeling of rat neutrophils for intravital microvascular studies
    • Yuan Y, Fleming BP: A method for isolation and fluorescent labeling of rat neutrophils for intravital microvascular studies. Microvasc Res 1990; 40:218-229.
    • (1990) Microvasc Res , vol.40 , pp. 218-229
    • Yuan, Y.1    Fleming, B.P.2
  • 19
    • 0022416745 scopus 로고
    • A more appropriate statistical method for analyzing mortality data in shock research
    • Knapp RG, Wise WC: A more appropriate statistical method for analyzing mortality data in shock research. Circ Shock 1985; 16:375-381.
    • (1985) Circ Shock , vol.16 , pp. 375-381
    • Knapp, R.G.1    Wise, W.C.2
  • 20
    • 0023029160 scopus 로고
    • Xanthine oxidase and neutrophil infiltration in intestinal ischemia
    • Grisham MB, Hernandez LA, Granger DN: Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 1986; 251:G456-G462.
    • (1986) Am J Physiol , vol.251
    • Grisham, M.B.1    Hernandez, L.A.2    Granger, D.N.3
  • 21
    • 0015421876 scopus 로고
    • Pancreatic hydrolases and the formation of a myocardial depressant factor in shock
    • Lefer AM, Barenholz Y: Pancreatic hydrolases and the formation of a myocardial depressant factor in shock. Am J Physiol 1972; 223:1103-1109.
    • (1972) Am J Physiol , vol.223 , pp. 1103-1109
    • Lefer, A.M.1    Barenholz, Y.2
  • 22
    • 0026342111 scopus 로고
    • Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
    • Butcher EC: Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity. Cell 1991; 67:1033-1036.
    • (1991) Cell , vol.67 , pp. 1033-1036
    • Butcher, E.C.1
  • 24
    • 0025819503 scopus 로고
    • Role of endothelial dysfunction in the pathogenesis of reperfusion injury following myocardial ischemia
    • Lefer AM, Tsao PS, Lefer DJ: Ma X-1: Role of endothelial dysfunction in the pathogenesis of reperfusion injury following myocardial ischemia. FASEB J 1991; 5:2029-2034.
    • (1991) FASEB J , vol.5 , pp. 2029-2034
    • Lefer, A.M.1    Tsao, P.S.2    Lefer, D.J.3    Ma, X.-L.4
  • 25
    • 0027457146 scopus 로고
    • Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock
    • Lefer AM, Lefer DJ: Pharmacology of the endothelium in ischemia-reperfusion and circulatory shock. Annu Rev Pharmacol Toxicol 1993; 33:71-90.
    • (1993) Annu Rev Pharmacol Toxicol , vol.33 , pp. 71-90
    • Lefer, A.M.1    Lefer, D.J.2
  • 26
    • 0027431321 scopus 로고
    • Anti-neutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs
    • Lefer DJ, Nakanishi K, Johnston WE, Vinten-Johansen J: Anti-neutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion in dogs. Circulation 1993; 88:2337-2350.
    • (1993) Circulation , vol.88 , pp. 2337-2350
    • Lefer, D.J.1    Nakanishi, K.2    Johnston, W.E.3    Vinten-Johansen, J.4
  • 27
    • 0026458579 scopus 로고
    • Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion
    • Carey C, Siegfried MR, Ma X-1, Weyrich AS, Lefer AM: Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion. Circ Shock 1992; 38:209-216.
    • (1992) Circ Shock , vol.38 , pp. 209-216
    • Carey, C.1    Siegfried, M.R.2    Ma, X.-L.3    Weyrich, A.S.4    Lefer, A.M.5
  • 29
    • 0023666065 scopus 로고
    • Integrins: A family of cell surface receptors
    • Hynes RO: Integrins: A family of cell surface receptors. Cell 1987; 48:549-554.
    • (1987) Cell , vol.48 , pp. 549-554
    • Hynes, R.O.1
  • 30
    • 0024999177 scopus 로고
    • Reperfusion-induced leukocyte infiltration: Role of elastase
    • Zimmerman BJ, Granger DN: Reperfusion-induced leukocyte infiltration: role of elastase. Am J Physiol 1990; 259:H390-H394.
    • (1990) Am J Physiol , vol.259
    • Zimmerman, B.J.1    Granger, D.N.2
  • 31
    • 0025359581 scopus 로고
    • Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor
    • Wash, DC
    • Rice WG, Weiss SJ: Regulation of proteolysis at the neutrophil-substrate interface by secretory leukoprotease inhibitor. Science Wash, DC 1990; 249:178-181.
    • (1990) Science , vol.249 , pp. 178-181
    • Rice, W.G.1    Weiss, S.J.2
  • 32
    • 0019800423 scopus 로고
    • Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G
    • Boudier C, Holle C, Bieth JG: Stimulation of the elastolytic activity of leukocyte elastase by leukocyte cathepsin G. J Biol Chem 1981; 256:10256-10258.
    • (1981) J Biol Chem , vol.256 , pp. 10256-10258
    • Boudier, C.1    Holle, C.2    Bieth, J.G.3
  • 35
    • 0029761141 scopus 로고    scopus 로고
    • Hydrogen peroxide induces leukocyte rolling: Modulation by endogenous antioxidant mechanisms including NO
    • Johnston B, Kanwar S, Kubes P: Hydrogen peroxide induces leukocyte rolling: modulation by endogenous antioxidant mechanisms including NO. Am J Physiol 1996; 271: H614-H621.
    • (1996) Am J Physiol , vol.271
    • Johnston, B.1    Kanwar, S.2    Kubes, P.3
  • 36
    • 0027481965 scopus 로고
    • The reaction of NO with superoxide
    • Huie RE, Padmaja S: The reaction of NO with superoxide. Free Radic Res Commun 1993; 18:195-199.
    • (1993) Free Radic Res Commun , vol.18 , pp. 195-199
    • Huie, R.E.1    Padmaja, S.2
  • 37
    • 0026340016 scopus 로고
    • Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes
    • Rubanyi GM, Ho EH, Cantor EH, Lumma WC, Parker-Botelho LH: Cytoprotective function of nitric oxide: Inactivation of Superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 1991; 181:1392-1397.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 1392-1397
    • Rubanyi, G.M.1    Ho, E.H.2    Cantor, E.H.3    Lumma, W.C.4    Parker-Botelho, L.H.5
  • 38
    • 0029159779 scopus 로고
    • Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
    • De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone Jr. MA, Shin WS, Liao JK: Nitric oxide decreases cytokine-induced endothelial activation. Nitric Oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995; 96:60-68.
    • (1995) J Clin Invest , vol.96 , pp. 60-68
    • De Caterina, R.1    Libby, P.2    Peng, H.B.3    Thannickal, V.J.4    Rajavashisth, T.B.5    Gimbrone M.A., Jr.6    Shin, W.S.7    Liao, J.K.8
  • 40


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