Evaluation of genotype data in clinical risk assessment: Methods and application to BRCA1, BRCA2, and N-acetyl transferase-2 genotypes in breast cancer

Genetic Testing

Volumn 1, Issue 3, 1998, Pages 157-164

  Rebbeck, Timothy R ^a   Rogatko, Andre ^b   Viana, Marlos A G ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; BRCA2 PROTEIN; NAT2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ADULT; AGED; ARTICLE; BREAST TUMOR; CASE CONTROL STUDY; ENZYMOLOGY; FEMALE; GENETIC SCREENING; GENETICS; GENOTYPE; HUMAN; JEW; MIDDLE AGED; MUTATION; RISK FACTOR; SMOKING; TUMOR SUPPRESSOR GENE;

ADULT; AGED; ARYLAMINE N-ACETYLTRANSFERASE; BRCA2 PROTEIN; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENES, BRCA1; GENES, TUMOR SUPPRESSOR; GENETIC SCREENING; GENOTYPE; HUMANS; JEWS; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; RISK FACTORS; SMOKING; TRANSCRIPTION FACTORS;

EID: 0031292811     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/gte.1997.1.157     Document Type: Review

References (17)

1. AMBROSONE, C.B., FREUDENHEIM, J.L., GRAHAM, S., MARSHALL, J.R., VENA, J.E., and BRASURE, J.R. (1996). Michalek cigarette smoking, N-acetyltransferase 2 genetic polymorphisms and breast cancer risk. JAMA 768, 250-252.
2. BOYS, R., and DUSMORE, I. (1987). Diagnostic and sampling models in screening. Biometrika 74, 365-374.
3. CLAUS, E.B., RISCH, N., THOMPSON, W.D. (1991). Genetic analysis of breast cancer in the Cancer and Steroid Hormone Study. Am. J. Hum. Genet. 48, 232-242.
4. DAWID, A.P. (1976). Properties of diagnostic data distributions. Biometrics 32, 647-658.
5. LINDLEY, D., and NOVICK, M. (1981). The role of exchangeability in inferences. Ann. Statistics 9, 45-58.
6. MARSHALL, R. (1988). Bayesian analysis of case-control studies. Stat. Med. 12, 1223-1230.
7. NEUHAUSEN, S., GILEWSKI, T., NORTON, L., TRAN, T., MCGUIRE, P., SWENSEN, J., HAMPEL, H., BORGEN, P. BROWN, K., SKOLNICK, M., SHATTUCK-EIDENS, D., JHANWAR, S., GOLDGAR, D., and OFFIT, K. (1996). Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer. Nature Genet. 13, 126-128.
8. ODDOUX, C., STRUEWING, J.P., CLAYTON, C.M., NEUHAUSEN, S., BRODY, B.C., KABACK, M., HAAS, B., NORTON, L., BORGEN, P., JHANWAR, S., GOLDGAR, D., OSTRER, H., OFFIT, K. (1996). The carrier frequency of the BRCA2 6174delT mutation among Ashkenazi Jewish individuals is approximately 1%. Nature Genet. 14, 188-190.
9. REBBECK, T.R. (1997). Molecular epidemiology of the human glutathione-S-transferase genotypes GSTM1 and GSTT1 in cancer susceptibility. Cancer Epidemiol. Biom. Prev. 6, 733-743.
10. REBBECK, T.R., VIANA, M., JORDAN, H.A., WEBER, B.L., and ROGATKO, A. (1996). Evaluation of susceptibility genes in disease risk assessment. Am. J. Hum. Genet. 59(4):A28.
11. ROA, B.B., BOYD, A.A., VOBCIK, K., and RICHARDS, C.S. (1996). Ashkenazi Jewish population frequencies for common mutations in BRCA2 and BRCA2. Nature Genet. 14, 185-187.
12. SOX, H.C. (1990). Common diagnostic tests use and interpretation. Amer. Coll. Physicians, Philadelphia.
13. VIANA, M.A.G., and FAREWELL, V. (1990). A test for diagnostic utility. Can. J. Stat. 18, 289-295.
14. VIANA, M.A.G., and FAREWELL, V. (1994). Assessing the diagnostic utility of a test. Biometric. J. 86, 131-145.
15. VIANA, M.A.G., and RAMAKRISHNAN, V. (1992). Bayesian estimates of predictive value and related parameters of a diagnostic test. Can. J. Statist. 20, 311-321.
16. VIANA, M.G., ROGATKO, A., and REBBECK, T.R. (1998). Statistical assessment of multi-valued diagnostic tests. Can. J. Statist. (in press).
17. ZELEN, M., and PARKER, R. (1986). Case-control studies and Bayesian inference. Statist. Med. 5, 261-269.